Researchers at the Cells-in-Motion Cluster of Excellence have decoded a mechanism found at the beginning of almost every inflammatory response. Their study provides a new approach to develop novel treatment options for many inflammatory disorders with many fewer side effects compared to current drugs.
The so called "diabetic retinopathy" and the "diabetic macular edema" are two of the most frequent ocular diseases in patients with diabetes, and both feature pathologic changes of blood vessel functions in the retina. Experimental data and measurements in patients suggest that these changes in blood vessel functions may originate from a lack of vasoinhibin hormones in the retina.
The first antibiotic against tuberculosis that has been developed in Germany is now ready for clinical testing. BTZ043, as the newly developed drug substance is called, is also effective against multidrug-resistant pathogens which are increasingly challenging successful treatment worldwide.
A new Collaborative Research Center will start in July with a total funding of nearly 14 million euros, headed by the German Institute for Experimental Biomedicine in Würzburg. The aim is to decode the complex and insufficiently understood functions of platelets, the so-called thrombocytes.
The heart of a neonatal mouse is capable of self-repair after tissue damage. However, this ability disappears during the first week of life. Researchers at the University of Helsinki investigate the molecular mechanisms underlying myocardial regenerative ability.
Researchers at the Paul-Ehrlich-Institut have reproduced measles virus transmission in an animal model. They were able to show that an efficient interaction with two cellular receptors plays a decisive role in the efficient transmission of the virus.
For over a century, we have known that high altitude reduces the amount of blood the heart pumps around the body with each beat. New research published in The Journal of Physiology has unearthed why this is the case and the findings will be important for people who live, travel and exercise at high altitudes.