LDN Labor Diagnostika Nord GmbH & Co. KG of Nordhorn at MEDICA 2019 in Düsseldorf -- MEDICA - World Forum for Medicine
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LDN Labor Diagnostika Nord GmbH & Co. KG

Am Eichenhain 1, 48531 Nordhorn
Germany
Telephone +49 5921 81970
Fax +49 5921 8197222
info@ldn.de

Hall map

MEDICA 2019 hall map (Hall 3): stand C15

Fairground map

MEDICA 2019 fairground map: Hall 3

Our range of products

Product categories

  • 03  Diagnostic Tests
  • 03.02  Immunochemistry testing, immunology testing
  • 03.02.03  Diagnostic tests for cancer

Diagnostic tests for cancer

  • 03  Diagnostic Tests
  • 03.07  Other diagnostics

Other diagnostics

Our products

Product category: Diagnostic tests for cancer

Free Metanephrines in Plasma

Free Metanephrines in Plasma   Cells derived form neuroendocrine tumours (e.g.  Pheochromcytoma) are known to produce Catecholamines which are secreted episodically via vesicles into the blood stream. But beside this a small portion of the Catecholamines is metabolized inside the cells to the corresponding Catecholamines metabolites – namely Metanephrine, Normetanephrine and 3-methoxy-tyramine – which are secreted at low levels continuously into the blood stream.   Recent studies and publications have shown that the quantification of these plasma free metanephrine (fMN) and plasma free normetanephrine (fNMN) is the most accurate biochemical marker for the clinical diagnosis of Pheochromocytoma and follow-up of pheochromocytoma patients.   LDN has developed enzyme immunoassays and isotopic assays for the quantitative determination of fMN and fNMN in human plasma with extraction.   The assays show the following common features: 
  • speed and ease of use
  • cost-effective
  • for in-vitro diagnostic and research applications
  • wide standard ranges
  • available as ELISA and RIA (with 15 weeks shelf-life)
  • the ELISA is automatable
  • freedom from drug interferences
  • excellent correlation with HPLC
  • single and multi parameter kits available

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Product category: Other diagnostics

Histamine ELISA

Histamine ELISA

In humans, histamine (β-imidazole ethylamine) is one of the most important mediators and takes part in the initial phase of an anaphylactic reaction (“immediate type” allergy).
It is produced by basophils and by mast cells found in connective tissues .
Of clinical interest is also the quantification of the histamine release from basophilic leucocytes in allergies (please refer to the add-on kit Histamine Release; reference no. BA E-1100).

The Histamine ELISA (BA E-1000) measures quantitively Histamine levels in plasma and urine and in conjuction with the add-on kit BA E-1100 the release of Histamine from whole blood.
The assay is intended  for in-vitro diagnosis and research applications

 

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Company news

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Oct 14, 2019

Re-Launch 3-MT-assay

3-Methoxytyramine

3-Methoxytyramine (3-MT) is a metabolite of the neurotransmitter dopamine formed by the introduction of a methyl group to dopamine by the enzyme catechol-O-methyl transferase (COMT).

The measurement of 3-MT allows the detection of dopamine-producing tumours:  For example a substantial number of patients with head-and-neck paragangliomas (HNPGL) have biochemically active tumors and only display increased excretion of 3-methoxytyramine, but not of other catecholamines or their metabolites.
The combined levels of free Metanephrine/Normetanephrine and free 3MT in plasma indicate a higher number of biochemically active HNPGLs than the 24-h urinary excretion rates of these markers.

Beside this 3-MT acts as a neuromodulator and can also induce behavioral effects involved in movement control in a dopamine-independent manner. Most of these effects are mediated by the trace amine associated receptor 1 (TAAR1) which in turn is involved in abnormal dopaminergic transmission, such as Parkinson's disease, dyskinesia and schizophrenia.

 

 

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About us

Company details

LDN was founded in 1996 in Nordhorn, Germany, with the aim to develop, manufacture and supply specialty in-vitro diagnostics test systems and innovative technologies to the clinical and research laboratory markets. From the beginning the determination of biogenic amines with immunological test systems was in the core of our business – where we are nowadays the world wide market leader. Integral part of this success are e.g. our assays for the quantitative determination of free metanephrines in plasma, the catecholamines, histamine and serotonin.

This positive outcome encouraged us to expand our business to related diagnostic areas such as food safety (HistaSure™ Fish Rapid Test, HisQuick™), food intolerance, neurotransmitters and amino acids. Next, LDN introduced a comprehensive endocrinological panel, especially also for niche parameters e.g. free testosterone, 17-OH-progesterone, chromogranin A, DHT, estrone. We continue to innovate on a consistent base, developing on average 5-7 new products a year.

LDN products are distributed in over 80 countries by a network of OEM partners and distributors and in North America through our daughter company Rocky Mountain Diagnostics. Our focus aside from selling great products is to support them. Our concern is your satisfaction and confidence in using the latest and newest technologies from our company. Our team is highly trained and experienced as both end users and developers. We believe this philosophy gives our support, in addition to efficiency, a personal touch exclusive to our products. We guarantee a 24-hour turnaround time on most all technical inquiries. Our company is privately owned, thus making our customers the number one priority. As such, we provide our customers with the best possible products and services.

We have meanwhile finished our facility expansion which increased our laboratory, office and warehouse space from 3,600 to 16,000 sq.ft.
Aside from spacious production facilities, R&D and QC laboratories, we have also doubled our refrigeration capacity from 900 to 1,600 sq.ft. At our disposal is also a seminar room and a fully equipped customer training area.
We look forward to having you as our guests in our new home!

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