Sanquin Reagents B.V. of Amsterdam at MEDICA 2017 in Düsseldorf -- MEDICA Trade Fair

Sanquin Reagents B.V.

P.O. Box 9190, 1006 AD Amsterdam
Plesmanlaan 125, 1066 CX Amsterdam
Netherlands

Telephone +31 20 5123599
Fax +31 20 5123570
reagents@sanquin.nl

This company is co-exhibitor of
Task Force Health Care

Hall map

MEDICA 2017 hall map (Hall 15): stand F56

Fairground map

MEDICA 2017 fairground map: Hall 15

Our range of products

Product categories

  • 03  Diagnostics
  • 03.03  Haematology / Histology / Cytology
  • 03.03.09  Immunohaematology (Blood grouping)

Our products

Product category: Immunohaematology (Blood grouping)

Magister C24

With Magister C24 we challenge the status quo. Magister C24 is the first fully automated blood group analyser specifically designed for laboratories with low throughput. We strongly believe this can help these labs forward as this allows them to work to the same high level of efficiency, quality and safety as labs with higher throughput. The design of Magister C24 ensures a cost-efficient, safe and fast work flow that is needed to continuously and quickly deliver accurate results to the clinic, which is necessary for optimal patient care.

Technical specifications
  • 2 Probes to give you the results faster
  • 24 Gel cards storage capacity for all types of Cellbind gel cards
  • 12 Cellbind gel cards per run
  • High resolution gel card reader for real life pictures
  • Multiple barcode checks throughout the process to ensure accurate results
  • Can hold 32 samples of different tube sizes
  • 20 positions for the reagent of your choice, including red cells stirrer
Software specifications
  • Easy to use due to its touch-screen monitor, clear software structure
  • Continuous loading of samples and reagents in combination with processing of the workload in random access makes your daily routine very efficient
  • The possibility to create your own protocols helps you find the solution that fits best to your unique situation
  • Bi-directional communication with LIS to report your results to the clinic fast and accurate
  • Keep track of every action with the full tracebility
Key features of Cellbind gel cards
  • One Cellbind gel card for all tests
  • Flexible system adaptable to your needs
  • Clear results with easy interpretation
  • Excellent diagnostic value
  • Cost-efficient

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Product category: Immunohaematology (Blood grouping)

Cellbind

Cellbind, a micro column immunofixation system
The Cellbind Screen assay is a micro column test system in which sensitized red cells from a suspension are caught by a gel matrix containing anti-IgG, anti-IgM, and anti-C3d in an enhancing high-density medium.

Benefits of Cellbind
The strongest advantages of Cellbind are the flexibility and the easy readable outcome.

1. Flexibility
Cellbind Screen is intended for use in the detection or identification of red cell antibodies, as well as for blood grouping, cross-matching and the modified direct antiglobulin test (DAT, for the detection of in vivo coating of red cells with antibodies and complement components).

2. Easy to read
In positive reactions, red cells will be caght in the top layer of the gel matrix. In negative reactions, only a discrete button of red cells at the bottom of of the micro column will be seen. Reading of Cellbind cards, by eye or with a reader, is very easy and unambiguous.

3. Easy for automation
Cellbind Screen is suitable for use in manual as well as (semi-)automated systems.
The test is based on the immunofixation of sensitized red cells in a micro column containing a gel matrix. The cell suspension is added to the incubation compartment of the micro column, together with the plasma, serum or blood grouping reagent to be tested.

Procedure
During the incubation phase antigen-positive red cells will bind the corresponding anti-red cell antibodies present in the plasma, serum or reagent. 
Next, the cards are subjected to three phases of centrifugation:
• In the first phase optimally sensitized red cells are caught by ligands: anti-IgG, anti-IgM and anti-C3d in an enhancing High Density Medium. This results in a 3-dimensional network of red cells, attached to each other by these ligands.
• In the second phase this network is compressed into aggregates during landing on the surface of the gel.
• In the third phase non-sensitized red cells will move towards the bottom of the micro column.

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Product category: Immunohaematology (Blood grouping)

Reagents for typing blood group antigens on red blood cells

Sanquin develops, produces and markets reagents for the typing of ABO, Rhesus and other blood groups.

ABO blood grouping reagents
These monoclonal reagents are available for different techniques like slide, MTP, spin tube and Cellbind for the typing of ABO blood groups.

Rhesus blood grouping reagents
These monoclonal reagents can be used in different techniques like slide, MTP, spin tube and Cellbind for the detection of Rhesus blood groups and D-variants.

Other blood grouping reagents
These monoclonal and polyclonal reagents can be used for typing other blood groups than ABO and Rhesus. Sanquin tries to offer a complete product range for these typings.

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Product category: Immunohaematology (Blood grouping)

Coombs sera and agglutination potentiators

Reagents for the (in)direct antiglobulin test (Coombs sera)
AHG (anti-human globulin) contains antibodies against human IgG. These antibodies bind to the IgG-molecules on the erythrocytes. This forms a bridge and the erythrocytes agglutinate. Most allo-antibodies directed against erythrocytes are IgG-antibodies.

The large majority of IgG-antibodies is not complement binding. However, there are examples of antibodies that could only be detected indirectly with anti-complement. Therefore, the composition and quality of the AHG reagents are important.

Polyspecific AHG reagent
Polyspecific AHG reagent is mainly used in the antiglobulin test in saline, albumin or LISS. In the PEG and polybrene technique always a-IgG is used. It contains only anti-IgG (monospecific anti-human globulin reagent). Anti-complement in these techniques practically always results in false positive results.

PEG
The PEG technique is very sensitive. Antibodies, that can be detected in other techniques only because of their complement activating capacity (like anti-Jka and anti-Jkb), can be detected in the PEG-IAT without the use of an anti-complement.

Agglutination potentiating reagents
The effect of agglutination enhancers is a reduction of the water mantle and ion cloud around the erythrocyte or an increase in the interaction between antigen and antibody.

Agglutination enhancers can influence the zeta potential so that incomplete antibodies can agglutinate red cells and can increase the binding (association) between antibody and antigen.

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Product category: Immunohaematology (Blood grouping)

Red blood cells

Red blood cells are used for conformation, screening and identification. Each identification panel contains positive cells for Kpa, Lua and Wra and k-neg cells. Screening panel 123 always contains Bga-, Bgb- and Bgc negative donors.

Red blood cells for antibody identification
Makropanel 16 consists of 16 different cell suspensions (3%) derived from individual donors all with blood group O. The Makropanel cells have been selected so as to ensure optimal antigen distribution for the identification of clinically significant red cell antibodies in 97% of the cases.

An extra advantage is the presence of a Kpa positive cell, a Lua positive cell, a RzR2 cell, a k negative cell and a Wra positive cell.

The cells of Makropanel 16-P are pretreated with the enzyme papain.

Red blood cells for antibody screening
Screening set 1 + 2
Screening set 1 + 2 can be used to screen sera for the presence of clinically significant red cell antibodies. However, an antigen is in general more readily detected when the gene coding for it is present in the homozygous form than when the gene is in the heterozygous form.

Screening panel 123
The cell suspensions (3%) used in this screening panel have been selected so as to ensure optimal antigen distribution for the detection of clinically significant red cell antibodies.

A donor positive for Cw-antigen is always present.

The fact that the donors used in this panel are often homozygous for the genes controlling the antigens present on their red cells, renders Screening panel 123 suitable for use in type and screen procedures.

Screening panel 123 always contains Bga-, Bgb- and Bgc negative donors.

Red blood cells for antiglobulin control
The principle of the test is the agglutination technique, which is based on antigen/antibody reaction. Coombs Control Cells should be added to every test tube yielding a negative result.

Coombs Control Cells are IgG sensitised Group O Rhesus D-positive human red cells that have been sensitized in vitro with different amounts of anti-D (IgG) antibodies.

Red blood cells for confirmation of ABO groups
Cell suspensions for the detection of alloantibodies anti-A and anti-B (A1 and B reagent red cells) and for the use as positive or negative control (O positive, O negative and A2 reagent red cells)

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About us

Company details

Sanquin provides blood services in the Netherlands on a not-for-profit basis. Sanquin is the knowledge institute in the field of blood, and conducts scientific research in the fields of blood transfusion medicine and immunology, applying this knowledge to the development and production of a range of pharmaceutical and diagnostic services.

Mission
Sanquin is a knowledge-driven not-for-profit organisation that supplies life-saving products, focussing on the needs of the care sector. Through scientific research, we look for and find new solutions for medical problems in the field of transfusion medicine, haematology and immunology. We are constantly aware of our responsibility to handle the donors’ gift carefully, responsibly and effectively, and to put the patients’ safety and welfare first.

Safety first
The organisation’s top priority is the health of patients and donors: safety always comes first. The safety of the blood transfusion chain from donor to patient is ensured by sophisticated production methods, rigid procedures, strict quality requirements and testing, as well as thorough staff training.

Sanquin tests donors before they give blood and excludes people at high risk of infectious diseases. All donations are tested, thereby minimising the risk of transmitting blood infections by blood products. Even though every possible precaution is taken, there remains a very small chance of a blood transfusion causing an infection through a virus or pathogen. That is why blood and blood products must be used with prudence.

Accurate administration to keep close track of what happens to blood is an integral part of ensuring maximum safety. Sanquin keeps records of who receives its products, and products can always be traced back to the donor. This data is kept for thirty years. Hospitals and pharmacists also keep track of which patient receives which blood product.

Transparency
Sanquin’s work ethics are designed to ensure a safe blood supply. The blood supply is a people-orientated activity, and the skills and commitment of Sanquin’s staff are the organisation’s greatest asset. Communication lines are efficient and transparent, thus nurturing the professionalism and commitment needed to ensure the high quality of our blood supply. The employees of Sanquin work according to a code of conduct.

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