Michigan Diagnostics LLC of Royal Oak at MEDICA 2017 in Düsseldorf -- MEDICA Trade Fair

Michigan Diagnostics LLC

2611 Parmenter Blvd, 48073 Royal Oak
United States of America

Telephone +1 248 4354472
Fax +1 248 4354537
customerservice@michdiag.com

This company is co-exhibitor of
Messe Düsseldorf North America

Hall map

MEDICA 2017 hall map (Hall 3): stand D29-4

Fairground map

MEDICA 2017 fairground map: Hall 3

Our range of products

Product categories

  • 03  Diagnostics
  • 03.01  Clinical chemistry
  • 03.01.14  Rapid tests - clinical chemistry

Rapid tests - clinical chemistry

Our products

Product category: Rapid tests - clinical chemistry

ELISA KITS

Quantitative Analysis of Total Tyroxine (T4) concentration in human serum

Thyroid gland is the source of L- thyroxine (T4), where (T4) is synthesized and stored. Thyroxine is one type of hormone, which circulates in the blood as an equilibrium mixture of free- and serum-bound hormone. More than 99% of T4 is reversibly bound to three plasma proteins in blood – thyroxine binding globulin(TBG) (70%), albumin (10%) and thyroxine binding pre-albumin(TBPA) (20 %). Less than 0.03% T4 is present in the circulation as unbound state in the blood. This small T4 amount represents the physiologically available hormone which is biologically active.
The presence of thyoid disorders in patients is determined by Immunoassay test. This test is the most reliable convenient and fast screening test for the determination of total T4. Levels of T4 are found to increase in hyper-thyroidism due to Grave’s disease and Plummer’s disease and in acute and subacute thyroiditis. Low levels of T4 have been linked with congenital hypothyroidism, myxedema, chronic thyroiditis (Hashimoto’s disease), and with some genetic abnormalities.

Principle of the Test

In this T4 EIA, Some amount of anti-T4 antibody is coated on microtiter wells. A constant amount of T4 conjugated with Alkaline phosphatase  and  a measured amount of human serum are added to the micro titer wells and sake before incubation. During incubation , T4  and conjugated T4 compete for the limited binding sites on the anti T4 antibody. After 30 minutes incubation at 370C temperature, the wells are washed by Tris buffer 4 times to removed unbound T4 conjugate. A constant amount of chemiluminescent Reagent is then added in each well and sake well and  keep the plate in the sample chamber of the luminometer and measure the intensity of l8ght (in RLU)  after every 15 minutes at 450 nm. The intensity of the chemiluminescent light is proportional to the amount of enzyme present and is inversely proportional to the amount of unlabeled T4 in the sample. T4 standards is tested in the same way as reference, and then calculate the T4 concentration in the unknown sample.

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Product category: Rapid tests - clinical chemistry

CHEMILUMINESCENT KITS

Introduction and Explanation of the Test

Quantitative Analysis of Total Tyroxine (T4) concentration in human serum 

Thyroid gland is the source of L- thyroxine (T4), Where (T4) is synthesized and  stored.  Thyroxine is one type of hormone, which circulates in the blood as an equilibrrium mixture of free and  serum bound hormone. More than 99% of T4 is revesibly bound to three plasma proteins in blood – thyroxine binding globulin(TBG) 70%, albumin (10%) and thyroxine binding pre-albumin(TBPA) (20 %). Less than 0.03% T4 is present in the circulation as unbound state in the blood. This small T4 amount represents the physiologically available hormone which is biologically active. 
The presence of thyoid disorders in patients is determined by Immunoassay test. This test  is the most reliable convenient and fast screening test for the  determination of total T4. Levels  of T4 are found to increase in hyper-thyroidism due to Grave’s disease and Plummer’s disease and in acute and subacute thyroiditis. Low levels of T4 have been linked with congenital hypothyroidism, myxedema, chronic thyroiditis (Hashimoto’s disease), and with some genetic abnormalities.
 
Principle of the Test

In this T4 EIA, Some amount of anti-T4 antibody is coated on microtiter wells. A constant amount of T4 conjugated with Alkaline phosphatase  and  a measured amount of human serum are added to the micro titer wells and sake before incubation. During incubation , T4  and conjugated T4 compete for the limited binding sites on the anti T4 antibody. After 30 minutes incubation at 370C temperature, the wells are washed by Tris buffer 4 times to removed unbound T4 conjugate. A constant amount of chemiluminescent Reagent is then added in each well and sake well and  keep the plate in the sample chamber of the luminometer and measure the intensity of l8ght (in RLU)  after every 15 minutes at 450 nm. The intensity of the chemiluminescent light is proportional to the amount of enzyme present and is inversely proportional to the amount of unlabeled T4 in the sample. T4 standards is tested in the same way as reference, and then calculate the T4 concentration in the unknown sample.

More Less

Product category: Rapid tests - clinical chemistry

COLORIMETRIC KITS

Introduction and Explanation of the Test

Quantitative Analysis of Total Tyroxine (T4) concentration in human serum 

Thyroid gland is the source of L- thyroxine (T4), Where (T4) is synthesized and  stored.  Thyroxine is one type of hormone, which circulates in the blood as an equilibrium mixture of free and  serum bound hormone. More than 99% of T4 is revesibly bound to three plasma proteins in blood – thyroxine binding globulin (TBG) 70%, albumin (10%) and thyroxine binding pre-albumin (TBPA) (20 %). Less than 0.03% T4 is present in the circulation as unbound state in the blood. This small T4 amount represents the physiologically available hormone which is biologically active.
The presence of thyoid disorders in patients is determined by immunoassay test. This test is the most reliable convenient and fast screening test for the determination of total T4. Levels of T4 are found to increase in hyper-thyroidism due to Grave’s disease and Plummer’s disease and in acute and subacute thyroiditis. Low levels of T4 have been linked with congenital hypothyroidism, myxedema, chronic thyroiditis (Hashimoto’s disease), and with some genetic abnormalities.
 
Principle of the Test

In this T4 EIA, some amount of anti-T4 antibody is coated on microtiter wells. A constant amount of T4 conjugated with alkaline phosphatase and a measured amount of human serum are added to the micro titer wells and sake before incubation. During incubation, T4 and conjugated T4 compete for the limited binding sites on the anti T4 antibody. After 30 minutes incubation at 370C temperature, the wells are washed by Tris buffer 4 times to removed unbound T4 conjugate. A constant amount of chemiluminescent Reagent is then added in each well and sake well and  keep the plate in the sample chamber of the luminometer and measure the intensity of l8ght (in RLU) after every 15 minutes at 450 nm. The intensity of the chemiluminescent light is proportional to the amount of enzyme present and is inversely proportional to the amount of unlabeled T4 in the sample. T4 standards is tested in the same way as reference, and then calculate the T4 concentration in the unknown sample.

More Less

About us

Company details

Michigan Diagnostics – Biotechnology and Specialty Chemicals

Michigan Diagnostics is one of the world’s leading manufacturers of diagnostic reagents and kits for research and clinical applications. We are committed to applying the highest quality and innovative solutions to service our clients’ needs. As we have grown we have expanded our operations into multiple operations which are located across the world. Those operations include but are not limited to the manufacturing of Diagnostic and research reagents, Diagnostic kits, rapid tests, clinical labs, medical facilities and cancer research.

Company History and Global Scope

We were founded in 1998 by Dr. Brij P. Giri with a single product line of modified cyclodextrins. By the end of 1998, we had filed our first set of patents and had begun manufacturing our highly sensitive chemiluminescent reagents for diagnostic and clinical uses. In 2008 we expanded our production to include biochemistry kits, CLIA kits, and Rapid test kits. We also created strategic partnerships with local and international companies to help develop and manufacture our diagnostic kits. All of our products do have some type of regulatory approval, these either come from the USA FDA, Chinese FDA or CE marked.

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