Surfix BV of Wageningen at COMPAMED 2017 in Düsseldorf -- MEDICA - World Forum for Medicine
Manufacturers Service

Surfix BV

P.O. Box 286, 6700 AG Wageningen
Bronland 12 B-1, 6708 WH Wageningen
Netherlands
Telephone +31 85 4881285
info@surfix.nl

This company is co-exhibitor of
IVAM Microtechnology Network

Hall map

COMPAMED 2017 hall map (Hall 8a): stand H23

Fairground map

COMPAMED 2017 fairground map: Hall 8a

Our range of products

Product categories

  • 09  Raw materials and adhesives
  • 09.07  Coatings, others
  • 10  Equipment and technologies for laboratories and manufacturing
  • 10.02  Manufacturing equipment
  • 10.02.07  Coating
  • 10  Equipment and technologies for laboratories and manufacturing
  • 10.02  Manufacturing equipment
  • 10.02.09  Thin film deposition
  • 11  Manufacturing Services
  • 11.05  Coating
  • 11  Manufacturing Services
  • 11.16  Forming
  • 11.16.15  Surface treatment

Our products

Product category: Coatings, others, Coating, Thin film deposition, Coating, Surface treatment

Nanowires

Nanowire based sensors have gained considerable interest as a general platform for ultrasensitive label-free electrical detection of biological and chemical species. These nanowire field effect transistor devices (NW-FETs) exhibit enhanced sensitivity compared to planar sensor platforms, due to the beneficial surface-to volume ratio of the nanowires, i.e. 1-D structure, which might enable single molecule detection.

In NW-FET devices the conductance through the nanowire is affected by the chemical environment, i.e. number of charged species, near the nanowire surface. Accordingly, modification of the nanowire with a molecular coating containing specific receptor-sites allows selective binding and consequent detection of chemical and biological species. In addition, by modifying individual nanowires in an array of nanowires with different receptors selective recognition of many different species in parallel can be accomplished, enabling high throughput screening for diagnostics and drug discovery.

Our surface modification technology has a number of benefits regarding the modification of NW-FET devices: 1) high reproducibility, 2) high chemical stability, 3) low number of interface traps at the organic-semiconductor interface, 4) selective modification of NWs, i.e. the surrounding surface is not modified.

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Product category: Coatings, others, Coating, Thin film deposition, Coating, Surface treatment

Microfluidics

Microfluidics deals with minute volumes of fluid in a network of micrometer-scale channels and allows miniaturisation and integration of precious complex chemical, biological and physical processes. Due to the micro-scale dimensions and the resulting high surface-area-to-volume ratio microfluidic systems offer numerous advantages over conventional analytical and (bio)chemical methods, including faster reaction times, greatly enhanced analytical sensitivity, reduced sample and reagent consumption, excellent temperature control, easy automation and parallelisation, and portability. Furthermore, microfluidics offers the opportunity to integrate all benchtop laboratory routines from beginning to end in one device, also known as the “lab-on-a-chip” or “micro total analysis systems (µTAS)” concepts. As a result, literature contains thousands of reports describing almost innumerable biological, biochemical and chemical applications, making microfluidics one of the most promising and rapidly developing technologies of present time.

Due to the increased surface-area-to-volume ratio and the continuously increasing complexity of microfluidic systems control of the surface properties is essential, for instance to regulate the electro-osmotic flow (EOF) and to prevent biofouling. Via our proprietary surface modification technology the channel walls can locally be modified with our molecular nanocoating, even after bonding of the chip, i.e. inside the microchannels. Our nanocoatings possess a long-term chemical stability and allow implementation of a wide variety of terminal functional groups, like complex (bio)organic molecules such as antibodies, DNA, proteins, cells, catalytically and redox active moieties, and groups with biofouling properties.   

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Product category: Coatings, others, Coating, Thin film deposition, Coating, Surface treatment

Optofluidic Biosensors

Optofluidic sensor devices have emerged as a highly promising (bio)chemical and label-free sensing technology with potential application in fields like biomedical research, healthcare, pharmaceuticals, and water, food and environmental monitoring. As (bio)molecular binding events alter the refractive index contrast and thus the propagation of light through the optical sensing element, direct quantitative and kinetic information on the molecular interaction at the sensor surface can be obtained. As a consequence, optofluidic sensor devices have the perspective to become one of the most sensitive label-free (bio)sensing systems.
 
In order to fulfill all the above mentioned promises and expectations appropriate surface immobilization chemistry is of utmost importance. For instance, the current status in literature shows that the sensitivities are worse when performing measurements in more complex media, such as blood serum or tissue lysate, whereas many analytes of interest even require limits of detections in a range below what at present can be detected. In particular, non-specific binding of interfering (bio)molecules is a major issues and thus underlying surface chemistry that combines efficient analyte capturing with minimal non-specific binding remains an area of intensive research.

In addition, in most optofluidic sensing devices the actual sensing surface corresponds only to less than one percent of the total surface area of the chip, though commonly used surface modification approaches do not differentiate between the sensing surface and its surrounding surface area, i.e. all surface is coated with the same analyte capturing layer. It is obvious that, especially at low analyte concentrations, this is detrimental for sensitivity and reproducibility of the sensing event.

Via our proprietary surface modification technology, based on innovative nanocoatings, the surface properties of optical (bio)sensor devices can easily be controlled and tuned, enhancing for instance wettability and analyte capture efficiency and/or eliminating non-specific binding. Furthermore, it allows us to selectively modify the sensing surface of the chip with an analyte capturing layer and its surrounding surface with an antifouling layer, considerably affecting the sensing performance.

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Product category: Coatings, others, Coating, Thin film deposition, Coating, Surface treatment

AFM tips

Atomic force microscopy (AFM) is one of the most powerful techniques for nanoscale characterization of materials surfaces. AFM makes use of a cantilever with a sharp tip (probe) at the end. When brought in close proximity of a surface, the cantilever bends in response to van der Waals interactions between the tip and the sample. Currently, most AFM tips are made of silicon or silicon nitride and have a tip radius of a few nanometers, allowing evaluation of the structural morphology of a materials surface with nanoscale accuracy.

By modifying AFM tips with a molecular nanocoating with specific chemical functionality (inter)molecular interactions can be probed and chemical information of a materials surface can be obtained, an approach known as chemical force microscopy (CFM). Typically surface modification on AFM tips is done with thiol based monolayer on gold-coated tips. However, because the initial chromium/gold layer is at least tens of nanometers, the tip radii are in the range of 40-100 nm, considerably reducing the resolution of CFM imaging. As a result, surface modification of the native oxide covered AFM tips with silane based monolayers has gained interest, however, here multilayer and cluster deposition leads to serious reproducibility issues.

Via our proprietary surface modification technology AFM tips can be modified with robust, functional and reproducible molecular coatings, without any tip enlargement or loss of resolution.

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Product category: Coatings, others, Coating, Thin film deposition, Coating, Surface treatment

Microsieves

Microsieves are microfiltration membranes with well-defined pores with, depending on the application, pore sizes in the range of 0.1 to 20 µm. A microsieve is composed of a rigid silicon support with on top a thin silicon nitride membrane (0.5 to 5 µm). Due to the high pore density, uniform pore size distribution and high aspect ratio (pore size versus membrane thickness) microsieves combine excellent size selective filtration with enhanced filter efficiencies at low flow resistance.

Hence, microsieves are applied in food industry, biotechnology and pharmaceutics, for instance, in beer or dairy filtration to remove bacteria, spores and yeast, microbial diagnostics of drinking water, waste water and blood samples, and production of well-defined functional emulsions and microspheres.

In many of these applications biofouling, i.e. non-specific adsorption of biomolecules, is a critical issue. Accordingly, modification of the microsieve surface with a stable biofouling molecular coating considerably improves microsieve performance. In addition, for microbial diagnostics microsieves can be functionalized with biofouling coatings with incorporated receptor sites for selective recognition of proteins and bacteria.     

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About us

Company details

Surfix BV was founded in 2011 as a spin-off from Wageningen University based on the broad knowledge and hands-on experience in chemical surface modification. Surfix BV is located in Wageningen and has access to advanced scientific instruments such as:

     XPS (X-ray Photoelectron Spectrometer) 
     XRR (X-ray Reflectivity)
     SEM (Scanning Electron Microscope)
     IRRAS (Infrared Reflection Absorption Spectroscopy)
     STM (Scanning Tunneling Microscope)
     AFM (Atomic Force Microscope)
     Fluorescence Microscopy
     Ellipsometry

We are a team of motivated people with extensive expertise in the field of surface chemistry and protein immobilization. We aim to span a ‘chemical bridge’ between the fields of biology and physics and offer our industrial partners innovative and custom-made solutions for their products.

 

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