EXBIO Praha, a.s. of Vestec at MEDICA 2017 in Düsseldorf -- MEDICA Trade Fair
Manufacturers

EXBIO Praha, a.s.

Nad Safinou II 341, 252 50 Vestec
Czechia

Telephone +420 261090595
Fax +420 261090660
orders@exbio.cz

Hall map

MEDICA 2017 hall map (Hall 3A): stand 3AB20

Fairground map

MEDICA 2017 fairground map: Hall 3A

Our range of products

Product categories

  • 03  Diagnostics
  • 03.03  Haematology / Histology / Cytology
  • 03.03.11  Monoclonal antibodies for cell surface antigens

Monoclonal antibodies for cell surface antigens

Our products

Product category: Monoclonal antibodies for cell surface antigens

AE1 (IgG1)

Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.

Specificity

Mouse monoclonal antibody AE1 recognizes acidic type cytokeratins, namely K10, 14, 15, 16, 19 (40-56 Kda). This antibody stains well the basal layer of epidermis and most epithelia.

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Product category: Monoclonal antibodies for cell surface antigens

L161 (IgG1)

CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.
Entrez Gene: 1q22-q23

Specificity

The mouse monoclonal antibody L161 recognizes CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.

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Product category: Monoclonal antibodies for cell surface antigens

MEM-123 (IgG3)

HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
  • Entrez Gene (HLA-A; human): 6p21.3
  • Entrez Gene (HLA-B; human): 6p21.3
  • Entrez Gene (HLA-C; human): 6p21.3

Specificity

The antibody MEM-123 reacts with all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.

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Product category: Monoclonal antibodies for cell surface antigens

MEM-255 (IgG2a)

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
Entrez Gene (human): 8q21.13

Specificity

The antibody MEM-255 recognizes an epitope (aa 235-280) of Csk-binding protein (Cbp) located in the cytoplasmic domain, also known as protein associated with glycosphingolipid-enriched microdomains (PAG).

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Product category: Monoclonal antibodies for cell surface antigens

Hs-14 (IgM)

VCP (valosin-containing protein), also known as p97, TERA, ALS14, IBMPFD, HEL-220, IBMPFD1, or HEL-S-70, is a member of a protein family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP is a structural protein that associates with clathrin and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. In sperm this intra-acrosomal protein can be used as a marker for evaluation of the physiological state of sperm cells as well as for selection of a suitable method of fertilization in the laboratories of assisted reproduction.
Entrez Gene: 9p13.3

Specificity

The antibody Hs-14 reacts with VCP (valosin-containing protein) a 220 kDa protein previously identified under the general name "intra-acrosomal protein".

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About us

Company details

EXBIO manufactures and supplies monoclonal antibodies for world wide distribution. We have become trusted and reliable supplier to many of the leading biotech companies. Because of the high performance characteristics and quality, our antibodies are widely recognized reagents and appear in catalogues of large number of immunochemical retailers.

INTERNATIONAL DISTRIBUTORS
Because our antibodies are well known among life science community, we distribute our products worldwide under EXBIO trademark through experienced local distributors. If you do not see your local distributor at our website, please contact us for the DIRECT DELIVERY.

BULK
EXBIO manufactures more than 90% of the products in the catalogue, which allows us to offer bulk quantities at very reasonable prices. Bulk quantities are suitable not only for manufacturers of immunochemical reagent based on our antibodies, but also for researchers that require larger amounts and want to save money.

OEM
EXBIO distributes the packed products to retailers who sell our products under their own trademark.

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