Leibniz-Institut für Analytische Wissenschaften ISAS - e.V.

Bunsen-Kirchhoff-Str. 11, 44139 Dortmund

Telephone +49 231 1392-0
Fax +49 231 1392-438

This company is co-exhibitor of
Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen


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MEDICA 2016 hall map (Hall 3): stand C80

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MEDICA 2016 fairground map: Hall 3

Our range of products

Product categories

  • 07  Medical Services and Publications
  • 07.01  Reports and analyses

Our products

Product category: Reports and analyses

Diagnostic Procedures

The work on diagnostic techniques concentrates on using the findings gained from basic research to develop clinically relevant applications. Part of the work focuses on the search for biomarkers specific to a particular illness, as these could provide insights into the aggressiveness of certain forms of tumours, for example, or advance research into neurodegenerative illnesses, such as Alzheimer's disease.

The researchers also work to develop and refine special techniques to identify such biomarkers. This includes a reliable analysis of conserved tissue samples from pathology: such collections of samples often stretch back over many decades and could help scientists to obtain a comprehensive picture of the differing courses taken by illnesses and their connection with genetic factors and environmental influences.

The implementation of guidelines to assure the quality of the work also plays an important role in this context – this is the only way to ensure that the methods can be used for diagnostic purposes at a later date.

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Product category: Reports and analyses

Systems Analysis

Communication in biological systems (such as cells and tissues) is complicated and quite diverse. Scientists therefore need to be able to measure as many components of these systems as possible in order to understand and reproduce the processes. For this reason, the work on the systems analysis topic concentrates on developing new concepts of examination and measurement for such complex analyses.

The complex biological matrix represents a particular challenge. Different components (such as proteins, carbohydrates and fats) are found in varying concentrations and these can fluctuate greatly depending on the cell type. For example, some proteins have several million copies per cell, whilst others have only ten copies. There are also cell components which are found even less frequently or are only very short-lived. Yet it is precisely these components that often are a major factor in biological systems because they are part of the signalling network. Thus it is not only the qualitative description of biological systems that is of great significance, but above all the quantitative description.

There are currently no satisfactory analytical techniques for many trace elements that can identify and analyse them in complex living networks. Although a series of different algorithms already exist for proteins which can interpret and critically evaluate the data, the strategies for analysing the data for metabolites and fats are still not so advanced.

The researchers working on this topic are furthermore devising miniaturised examination systems. Such techniques and instruments provide a high sample throughput at reduced costs because they consume less sample material. They therefore ideally complement high throughput methods in bioanalytics. In addition, microsystems enable an excellent spatial and temporal control of processes in the smallest space – very similar to the conditions in a cell.

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Product category: Reports and analyses

Transfer & Service

We want to share the results of our research and the analytical techniques that we develop with partners from science and business. The aim is to help them overcome scientific and technical challenges, in particular those involving health research and healthcare services, and to acquire them as specialist users and experts in practical applications for our interdisciplinary research projects. However, our technologies are not limited to the field of health research: Our extensive methodical expertise and our excellent technical equipment make us a suitable partner for analyses in other areas of application.The transfer programmes and services offered by ISAS range from advice provided to researchers in other scientific institutions, to associations and to political policy-makers, to joint research with businesses and contract research through to individual measurements and the provision of analytical standards. The institute also provides licenses for patented innovations.

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Product category: Reports and analyses

Biohybrid interfaces

Interfaces are of great interest in biosciences: for example, in the research of cell membranes which forward signals and transport molecules, or surgical implants whose surface should not be rejected by the body. Hybrid interfaces consisting of biomolecules and inorganic materials therefore have great scientific relevance and enormous potential for innovations. In this context, ISAS is particularly interested in the use of biomolecules as nanoswitches for signal transduction, in biocatalysis or in biosensor systems.

In order to examine and understand such systems, methods need to be developed which enable a differentiated analysis of the structure and the interplays between the different materials. Firstly, it is important that samples are not destroyed and are thus available for further analysis even after examination. Secondly, samples should be able to be investigated in their natural environment.

Analysis methods drawn from the field of optical spectroscopy are ideally suited for such purposes. They deliver information on the composition, structure and electrical properties of an interface and enable measurements with spatial and temporal resolution. Researchers at ISAS deploy other methods of investigation besides optical spectroscopy to enable a compartmentalised, detailed analysis: these methods include Near Ambient Pressure X-ray Photoelectron Spectroscopy (NAP-XPS), Near Ambient Pressure Scanning Electron Microscopy (NAP-SEM) and Scanning Probe Microscopy (SPM). This multi-method approach allows complex interfaces to be reliably analysed in great detail.

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Product category: Reports and analyses

Biomolecular Sensors

Functionalised surfaces enable multi-faceted applications in biomedicine. For instance, they are needed to construct biosensors in which inorganic and organic components are in direct contact. They can quickly "recognise" certain substances in a sample in a targeted manner.

An inorganic surface can be coated with biomolecules, such as enzymes or alcohols. As enzymes are highly specific and only react with selected substances, this method is well suited for demonstrating the presence of certain substances. This technology is in everyday use even today, such as in the blood glucose test strips for diabetics.

Despite the potential of this technology, it is still in the initial stage of development. Research into functionalised surfaces must be improved if good sensors of this type are to be built. New methods need to be developed for this purpose, which enable things like the structure, functionality, stability and the interplay between the sample and the surrounding medium to be examined in de¬tail, without having to destroy the sample beforehand.

An alternative approach is based on surface plasmon resonance (SPR). This is a new method developed at ISAS to demonstrate the presence of individual viruses or other nanoparticles in their natural environment. Each nanoparticle bonded to the sensor surface shows up in the image as a bright stain and can be observed directly. This technology can be used to develop rapid tests to identify certain viruses, for example, or to examine the air for nanoparticles. In addition, new methods to investigate processes of membrane transport in cells could be derived.  

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