New biomarker predicts side effects of tuberculosis therapy
29/08/2024
Researchers at the Research Center Borstel, Leibniz Lung Center, have discovered a biomarker that can predict the risk of nerve disease during tuberculosis therapy.
University of Notre Dame
LED Implant: A new approach to deep-seated cancer treatment
08/08/2024
A team of engineers and scientists at the University of Notre Dame has developed a wireless LED device that can be implanted to treat deep-seated cancers. This device, when combined with a light-sensitive dye, not only destroys cancer cells but also activates the immune system to target the cancer. The research findings were published in Photodiagnosis and Photodynamic Therapy.
Karin Kaiser/MHH
Heart health: New tool developed to investigate telomere length
10/06/2024
A research team from Hannover Medical School (MHH) has developed a new molecular tool to investigate the influence of telomerase on the development of heart muscle cells. This study could have significant implications for the treatment and prevention of heart diseases.
New findings on short-term cultivated CAR T cells in cancer treatment
28/05/2024
Chimeric Antigen Receptor T (CAR T) cells are a breakthrough in immunotherapy, offering hope for blood cancer patients who have exhausted other options. These genetically modified cells are designed to attack cancer cells by recognizing specific antigens. The therapy has shown promise, particularly in treating B-cell leukemias and lymphomas.
HZDR / Anja Schneider
HZDR team introduces novel pathogen detection approach
12/03/2024
Detecting diseases early or predicting their onset is crucial for healthcare. Dr. Larysa Baraban's team at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) develops miniaturized biosensor devices using nanomaterials.
University of Jyväskylä
Antiviral resin destroys COVID-19 from plastic surfaces
06/02/2024
Researchers at the University of Jyväskylä in Finland are pioneering the development of antiviral surfaces to mitigate the spread of infectious diseases, particularly focusing on coronaviruses.
Microneedle array patches: vaccinations made easy
29/01/2024
Dissolvable microneedle array patches (MAPs) consist of tiny, rapidly dissolving needles that can efficiently deliver vaccines into the skin. Their stability over time and easy application gives them great potential to not only simplify the vaccination process during a pandemic, but also in increase vaccination rates in low- and middle-income countries.
Nasal antibody spray demonstrates potential for COVID-19 prevention
26/01/2024
Researchers at the Karolinska Institutet in Sweden have achieved a significant breakthrough in COVID-19 prevention with the development of a nasal antibody spray. This approach offers new possibilities for enhanced protection against SARS-CoV-2 and its various variants, providing hope for high-risk individuals.
UQ
Protecting against zika virus with a microarray patch
22/01/2024
In the global fight against the Zika virus, researchers are developing a vaccine patch that promises an effective and painless solution. This needle-free vaccine patch, utilizing the high-density microarray patch (HD-MAP).
USZ
Understanding and fighting tumors better with new algorithms
21/12/2023
The University Hospital Zurich, the University of Zurich and the diagnostics company Roche are expanding their collaboration in cancer research. In the fully digitalized Morphomolecular Pathology Laboratory, they are developing algorithms that can further improve the effectiveness of immunotherapies.
gpointstudio
Coronavirus: Model can predict the evolution of new variants
31/10/2023
An international research team from the University of Cologne and the Icahn School of Medicine, Mount Sinai (New York) has developed a model that predicts the likely evolution of variants of the SARS-CoV-2 virus.
Charlotte Perhammar/Linköping University
CT scan can reveal immune system ageing
20/10/2023
With age, the glandular tissue in the thymus is replaced by fat, but, according to a new study from Linköping University, the rate at which this happens is linked to sex, age and lifestyle factors.
Jonna Alanko/Science Immunology
How immune cells migrate
11/09/2023
When fighting disease, our immune cells need to reach their target quickly. Researchers at the Institute of Science and Technology Austria (ISTA) now discovered that immune cells actively generate their own guidance system to navigate through complex environments.
Beate Armbruster/University Hospital of Tuebingen
Protection for cancer patients
05/09/2023
Tübingen T-cell activator offers protection against coronaviruses in immunocompromised patients
InfectoGnostics
InfectoGnostics study: Benefits of on-site tests in general practices
05/09/2023
General practitioners (GP) regularly use on-site rapid tests because they find their application useful. However, frequent utilisation fails due to costs and remuneration regulations. These are the results of a study by InfectoGnostics researchers at the University Hospital Jena in the project "POCT-ambulant", in which 292 GPs in Thuringia, Bremen and Bavaria participated.
Karin Kaiser / MHH
More impact against cancer
04/09/2023
MHH molecular physician Professor Dr. Dr. Schambach wants to use genetically modified natural killer cells to find new therapeutic options against three particularly malignant cancers. The EU is funding the project with 3.8 million euros
Uni Halle / Esfahani Golbarg
Pharmacy: Using starch as a novel drug transporter?
30/08/2023
A special type of starch could soon be used as an excipient in medicine to improve the treatment of patients.
Anne Günther/Uni Jena
Timing is key in cortisone treatment of inflammation
30/08/2023
A special type of starch could soon be used as an excipient in medicine to improve the treatment of patients.
Gregor Hübl/University of Bonn
Researchers decode new antibiotic
29/08/2023
Cooperation between the University of Bonn, the USA and the Netherlands cracks the mode of action of clovibactin
LMU
Immunotherapy: Antibody kit to fight tumors
25/08/2023
A new study highlights the potential of artificial DNA structures that, when fitted with antibodies, instruct the immune system to specifically target cancerous cells.
LanaSweet
Research gives new insights into fighting antimicrobial resistance
25/08/2023
Cooking food thoroughly and avoiding some types of vegetables and salad during a course of antibiotic treatment could potentially reduce antibiotic resistance, by preventing bacteria carrying resistance genes getting into the gut, according to a new study.
Cell Press | ©Kolabas et al.
A new ally in fighting brain diseases: our very own skull
16/08/2023
Alzheimer's, stroke, multiple sclerosis and other neurological diseases cause severe damage due to neuroinflammation mediated by immune cells.
monkeybusiness
Pandemic prevention: progress in research infrastructure
15/08/2023
The Covid-19 pandemic has clearly shown that there is still a lot of potential in research structures and funding to better manage a pandemic. Prevention plays just as important a role as dealing with the pandemic. Technological measures that can facilitate virus detection or help to analyze the course in more detail need to be developed.
Shaiith
AI shows how Aspergillus fumigatus gets comfortable in the lungs
14/08/2023
Aspergillus fumigatus strains that infect humans have a significantly altered metabolism compared to other strains in the environment. At the same time, infection with the fungus leads to an apparent change in the human lung microbiome.
Eijiro Miyako from JAIST
Cancer photoimmunotherapy: novel liquid metal nanoparticles
10/08/2023
JAIST researchers create liquid metal nanoparticles (PEG-IMIQ-LM) for cancer treatment, merging photothermal therapy and immunotherapy. Disintegration delivers immunomodulants and tracks cancer cells in real-time. Immune checkpoint inhibitor enhances cancer removal. Promising for future cancer theranostics, with clinical trials anticipated in a decade.
Leipzig University
Multiple sclerosis: Myelin may be detrimental to nerve fibres
05/07/2023
Researchers at Leipzig University and Max Planck Institute for Multidisciplinary Sciences in Göttingen have discovered that myelin, which was previously thought to be solely protective, can actually threaten the survival of the axons.
drazenphoto
Revolutionizing virus detection: the power of AI and CRISPR
04/07/2023
In the midst of the COVID-19 pandemic, scientists and researchers have been tirelessly working to develop innovative and accurate tests to identify the presence of viruses. One breakthrough technology that has emerged is the combination of artificial intelligence (AI) and CRISPR, which has revolutionized virus detection.
yavdat
AI enables first integrated single-cell atlas of the lung
15/06/2023
Can a human organ be mapped on a single-cell level to learn more about each individual cell? And can we learn how different these cells are from person to person? Helmholtz Munich researchers and their collaborators have taken up this challenge and developed the Human Lung Cell Atlas using artificial intelligence (AI)-based techniques.
Pixabay
Lung: bacterial colonisation also depends on genes of the host
13/06/2023
We know from previous studies that changes in the lung microbiome are associated with diseases such as cystic fibrosis, asthma or chronic obstructive pulmonary disease (COPD). Environmental factors such as smoking, nutrition in infancy or the use of antibiotics are important factors for the composition and stability of the microbial community in the lung.
MPI für Multidisziplinäre Naturwissenschaften
Dementia: poorly insulated nerve cells promote Alzheimer's disease in old age
08/06/2023
Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen have shown that defective myelin actively promotes disease-related changes in Alzheimer’s. Slowing down age-related myelin damage could open up new ways to prevent the disease or delay its progression in the future.
Anna Schroll/Leibniz-HKI
Model shows intestinal bacteria influence growth of fungi
22/05/2023
The bacteria present in the intestine provide information about the quantities of fungi of the potentially disease-causing Candida genus.
leungchopan
AI helps create better, simpler hepatitis, COVID-19 tests
11/05/2023
University of Florida scientists have used artificial intelligence tools to simplify a test that works for both hepatitis C and SARS-CoV-2, the virus that causes COVID-19. The simplified test happens in one small test tube in just a few minutes.
Petr Chlanda
Luring the virus into a trap
04/05/2023
Heidelberg researchers describe mechanisms that could help prevent infections with the influenza A and Ebola viruses.
Ines Villalba (EPFL)
Antibiotic resistance: fast, cheap, and easy test method
02/05/2023
“We have developed a technique in our laboratories that allows us to obtain an antibiogram within 2-4 hours – instead of the current 24 hours for the most common germs and one month for tuberculosis,” says Dr Sandor Kasas at EPFL.
Magnus Johansson
Wound dressing reveals infection
26/04/2023
A nanocellulose wound dressing that can reveal early signs of infection without interfering with the healing process has been developed by researchers at Linköping University, Sweden.
Uni Tübingen
Targeted computer modelling to accelerate antiviral drug development
31/03/2023
Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents.
Gustavo Raskosky/Rice University
Upgraded tumor model optimizes search for cancer therapies
27/03/2023
Rice University researchers developed an upgraded tumor model that houses osteosarcoma cells beside immune cells known as macrophages inside a three-dimensional structure engineered to mimic bone. Using the model, bioengineer Antonios Mikos and collaborators found that the body’s immune response can make tumor cells more resistant to chemotherapy.
JoPanwatD
AI finds targets for CAR-T cell therapy against acute myeloid leukemia
20/03/2023
Unlike other forms of blood cancer, acute myeloid leukemia (AML) cannot currently be treated with CAR-T cell immunotherapy. The reason is that specific molecular targets with which certain immune cells could specifically target AML cells are lacking, which would permit the immune system to attack cancer.
ckstockphoto
Smart microscopy works out where to take the picture
16/03/2023
Researchers at Lund University in Sweden have now developed a software solution for smart, data-driven microscopy, which makes this possible.
AG Hoelzel/UKB
Artificial intelligence to help tumor immunology
09/03/2023
Developing methods to predict the nature of the tumor microenvironment is the goal of researchers from the Clusters of Excellence ImmunoSensation2 and the Hausdorff Center for Mathematics (HCM) led by Prof. Kevin Thurley at the University of Bonn.
Eurice Office
Personalised health blueprint to prevent and predict inflammatory bowel disease
07/03/2023
Project led by PMI member Prof. Andre Franke aims to empower people affected by Crohn’s disease and ulcerative colitis by developing interdisciplinary solutions for improved disease prevention and health promotion.
Karin Kaiser / MHH
What leads to severe COVID-19 diseases?
01/03/2023
Infection with SARS-CoV-2 leads to severe disease in some people, while others do not get ill or only experience mild disease. But why is this the case? Unfortunately, we do not know exactly. We do know that an overactive innate immune system is causing severe COVID-19 disease, but it is unclear how this is regulated.
Paul Scherrer Institut/Markus Fischer
Using light to switch drugs on and off
27/02/2023
In the ImageTox project, the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the CISPA Helmholtz Center for Information Security are pooling their expertise in the fields of drug discovery and artificial intelligence (AI).
Dietze / HIPS
HIPS and CISPA join forces to make future active ingredients safer
23/02/2023
In the ImageTox project, the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the CISPA Helmholtz Center for Information Security are pooling their expertise in the fields of drug discovery and artificial intelligence (AI).
HAWK
Imaging: role of immune cells in early diabetic cataract development
22/02/2023
The team of researchers, led by Prof. Dr. Ali Hafezi-Moghadam, Director of the Molecular Biomarkers Nano-Imaging Laboratory (MBNI), in collaboration with Professor Dr. Christoph Rußmann, Dean of the Health Campus and a Visiting Professor at MBNI, found early signs of damage in the eye before the onset of type 2 diabetes.
HIPS/Boese
New cell model for the human lung
16/02/2023
A team led by Prof Claus-Michael Lehr of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has developed a novel human lung cell line that should enable much more accurate predictions of the behavior of active substances or dosage forms in humans than previous systems.
Vaibhav Srivastava
Mucus-based gel improves bone graft results, promotes healing
14/02/2023
Molecules from mucus can be used to produce synthetic bone graft material and help with the healing of larger bone loss, a new study found.
wichayada69
Funding to produce biodegradable antiviral and antibacterial materials
08/02/2023
A new junior research group at Freie Universität Berlin, which will investigate the production of biodegradable antiviral and antibacterial materials, with one of the goals of synthesis being new alternatives to conventional antibiotics, will receive a total budget of more than 1.8 million euros from the German Federal Ministry of Education and Research (BMBF) over the next five years.
Universitätsmedizin Halle
Long COVID: blood values indicate reprogramming of immune cells
26/01/2023
The underlying mechanisms of long COVID are not yet fully understood. Molecular clues to different subgroups of long COVID have now been provided by a research group at University Medicine Halle.
Messe Düsseldorf/C. Tillmann
RNA technologies make targeted immune activation possible
03/11/2022
MEDICA 2022 is right around the corner, ready to deliver insights into the advancements and innovations in laboratory medicine. One of the key topics of the MEDICA LABMED Forum is RNA technologies and the wide range of applications that involve cell biology. RNA technologies not only enable Covid-19 vaccines but promise an array of treatment options for genetic diseases, in and beyond oncology.
DC_Studio
Why some people get a more severe COVID-19 progression than others
22/08/2022
A team of scientists from the Berlin Institute of Health at Charité (BIH) together with colleagues from the United Kingdom and Canada have found genes and proteins that contribute to a higher risk of severe COVID-19.
MICROGEN@GMAIL.COM
Molecular markers: predicting the most effective treatment for IBD
09/08/2022
Early effective treatment can help manage this condition and improve the quality of life of patients. A research project aims to identify molecular markers to better assess the chances of success of certain biological therapies and subsequently determine the best individualized treatment plan.
Manabu Tokeshi
SARS-CoV-2: rapid method to quantify antibodies
29/07/2021
Scientists have developed a rapid, highly accurate test to detect antibodies against the spike protein of SARS-CoV-2 in human serum, opening a new avenue for understanding the full extent of the pandemic and evaluating the effectiveness of vaccines.
virtual.MEDICA 2020: Experience medicine online
02/11/2020
This year is completely different! Normally, we would offer you an advanced peek into the MEDICA’s halls in Dusseldorf at this point. But due to the corona pandemic, the trade fair takes place online as virtual.MEDICA. We nevertheless took a look at this year’s topics of special interest.
by UVentions
Hygiene: Smart protection against pathogens like the coronavirus
23/03/2020
Germs such as bacteria, viruses or pathogenic fungi can spread from one person to another through direct contact when we shake hands or touch objects. People touch door handles and push elevator buttons in public places and constantly move in and out of spaces. Regular manual high-level disinfection is practically impossible. UVentions GmbH has found an intelligent solution for this problem.
rhCollagen: genetically engineered building block for regenerative medicine
03/02/2020
Collagen is the stuff that holds our bodies together and that houses our cells. In regenerative medicine, it is also the stuff that can be applied to wounds to support healing. However, collagen from animal or human sources has some drawbacks for today’s medicine. This is where rhCollagen from the Israeli company CollPlant comes into play.
Endoprosthetic surgery: modern and traditional approaches
01/01/2020
Surgery is required if you need an artificial joint. Patients and doctors must select the type of surgery that’s best suited and choose between robot-assisted, traditional or minimally invasive surgical approaches. Post-operative risks should be kept to a minimum, while benefits should outweigh any possible complications.
Endoprostheses: regaining independence and mobility
01/01/2020
Joints can suddenly or gradually deteriorate and lose their natural strength, whether it’s due to accidents, diseases or simple wear and tear. In some of these cases, implants of artificial joints – endoprostheses - can help. As a joint replacement, they are designed to stay in the body for as long as needed and as such improve the patient’s quality of life and mobility.
Endoprostheses: between possibility and reality
01/01/2020
When natural joints lose their ability to function, they can be completely or partially replaced by artificial joints, also called endoprostheses. Endoprostheses must be of a certain quality, as they should remain in the body as long as possible. In addition to some risks, endoprostheses can also contribute to a mobile and carefree life for young and old.
Medicine at the pulse of time: Innovations and trends at MEDICA 2019
04/11/2019
Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
Fraunhofer ISS
AI software: "iSTIX opens your world to the possibilities of digital pathology"
08/10/2019
The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
Antibiotic resistance: technical tricks against pathogens
01/08/2019
An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
Sports medicine - performance values in best health
01/07/2019
Those who integrate physical activities into their own lifestyle live healthier and more balanced. But where are the physical limits? Can health status measurements also be carried out on the road? Discover more about how sports medical examinations contribute to maintain performance and minimize health risks in our Topic of the Month.
Sports medicine – keep moving to stay healthy
01/07/2019
Physical activity plays a big role in today's society. Whether you are an amateur or professional athlete – incorporating exercise into your life positively impacts your mental and physical health. Ideally, sport should be fun, pressure-free and not overburden you. But can you measure individual performance and align it with sports?
Functional Imaging: The puls of modern oncology
17/06/2019
Medical imaging techniques have developed considerably in recent decades. In addition to morphological imaging techniques more and more functional imaging techniques are used in oncology that can continously record the functions of specific organs locally and regionally in real time. These are groundbreaking for diagnostics, therapies and preoperative preparations.