Holographic imaging uses the precise control of light patterns to create highly detailed images - a new approach for endoscopy and microscopy. "In our systems, we use advanced algorithms to guide light through complex environments, such as multimode optical fibers, enabling high-resolution imaging in areas that traditional optics cannot reach," explains Prof. Cizmar. Using hair-thin endoscopes, the technology reaches deep tissue structures without major interventions.
While clinical applications are still in development, Prof. Cizmar sees the greatest potential in neuroscience. "Our primary target is Neuroscience, specifically unveiling secrets of the brain and searching for combat strategies against severe diseases, such as Alzheimer’s or Parkinson’s," he says. A long-term goal is to use spectroscopic methods to enable light-based biopsies - i.e. chemical contrast images without removing tissue. This could replace conventional, time-consuming histopathological examinations and speed up diagnosis considerably.