Cassian Afting, AG Wittbrodt
Controlling organoid development with the help of DNA microspheres
27.09.2024
A research team from Heidelberg University and the Max Planck Institute for Medical Research has developed a new method of molecular engineering. This makes it possible to precisely control organoids and improve their complexity. With the help of DNA microspheres, growth factors can be released in a targeted manner to recreate tissue structures more realistically.
Thomas Dennison/University of Cambridge
Lab-grown 'mini-guts' offer new insights for Crohn’s disease treatments
06.09.2024
Researchers at the University of Cambridge have developed lab-grown "mini-guts" to better understand and treat Crohn’s disease, a chronic inflammatory bowel disease affecting millions worldwide. These mini-guts, or organoids, mimic the gut lining's key functions and could pave the way for more personalized and effective treatments.
Heart transplants: Improved outcomes with "heart-in-a-box" technology
22.08.2024
A recent study from the University of Gothenburg, published in The Lancet, highlights a significant improvement in heart transplant outcomes when donor hearts are preserved using hypothermic oxygenated machine perfusion, commonly known as "heart-in-a-box," compared to the traditional method of cold static storage.
Silke Riegger, 3R-Center
Diabetes: technology enhances molecular understanding
26.03.2024
With over seven million individuals in Germany affected by diabetes, science still faces challenges in drug research. However, under the leadership of Prof. Peter Loskill from both the NMI and the University of Tübingen, scientists have devised a method that markedly enhances our understanding at the molecular and cellular levels within the pancreas.
Lobachad
Enhancing neonatal intensive care with ArtPlac project
19.01.2024
The European Union is providing €3.57 million in funding for the "ArtPlac" research project, aimed at developing innovative medical technology for the treatment of premature and newborn infants in neonatal intensive care.
XiXinXing
Evaluating brain tumours with artificial intelligence
22.12.2023
One application area of artificial intelligence (AI) is in medicine, especially in medical diagnostics. For instance, scans can be analysed automatically with the help of algorithms. An international and interdisciplinary team led by researchers from TU Darmstadt recently investigated whether AI can better evaluate images of brain tumours.
FabianMontano
Organ banks and the potential of deep-freezing
28.11.2023
We still face major challenges when it comes to the availability of donor organs. Organ banks could be a promising solution to shorten waiting times and save more lives - but only if we manage to preserve donor organs for longer.
David Callahan
Eye implant may be used to treat diabetes
27.10.2023
Researchers in Sweden have developed a microscale device for implantation in the eye, which presents new opportunities for cell-based treatment of diabetes and other diseases.
iLexx
Why tuberculosis bacteria form long chains
25.10.2023
A researcher team from Ecole Polytechnique Federal de Lausanne led by Dr. Vivek Thacker now group leader at the Department of Infectious Diseases at Heidelberg University Hospital have studied why tuberculosis bacteria form long strands and how this affects their infectivity.
NMI
Menopause: leveraging organ-on-chip technology for new insights
09.10.2023
Addressing the impact of female menopause on dynamic resilience and exploring preventive and therapeutic strategies is the aim of an international and interdisciplinary research group led by Prof. Dr. Peter Loskill from the NMI Natural and Medical Sciences Institute and the Eberhard Karls University of Tübingen.
MPIMIS
Cellular cartography: sizes and abundance revealed
27.09.2023
An international team of scientists has created the first comprehensive index of human cells, mapping the sizes and abundance of all cell types across the entire body.
Peer Erfle/IMT
Microchips: better understand diseases like schizophrenia
15.09.2023
The European Research Council (ERC) has announced the recipients of its prestigious Starting Grants. Among them is a researcher from the Technical University of Braunschweig: Dr. Thomas Winkler will receive €1.5 million for his research on modular organ-on-chip technology to better understand neuropsychiatric disorders such as schizophrenia.
Patrick Mansell/Penn State
High-speed bioprinting of bones, tracheas, organs
28.07.2023
Developing technology to quickly and efficiently bioprint human tissues at scale is the goal of a new project led by Penn State researchers. When fully developed, the technology will be the first to enable the fabrication of scalable, native tissues such as bones, tracheas and organs.
Karin Ziegler / TUM
Cardiac disease: new technique shows cause of sleep disturbance
27.07.2023
In a paper published in the journal Science, a team at the Technical University of Munich (TUM) shows that heart diseases affect the production of the sleep hormone melatonin in the pineal gland.
Karin Kaiser / MHH
Adsorber in blood purification: widely used, no proven benefit
19.07.2023
Many hospitals use the adsorber CytoSorb to purify the blood of seriously ill patients in order to trap inflammatory substances and prevent the life-threatening cytokine storm. MHH researchers have now found in a meta-study that the treatment does not reduce mortality and may even cause harm.
Natabuena
Functional imaging: intestinal and liver diseases mutually influence each other
06.07.2023
The research groups of Prof. Trautwein (University Hospital RWTH Aachen) and Prof. Hengstler (Leibniz Research Centre for Working Environment and Human Factors in Dortmund) have made a surprising discovery about the interaction of the liver and the intestine.
Gregor Hübl / Universität Bonn
Researching organoids: two new Argelander Professors at the University of Bonn
21.06.2023
Two new assistant professors at the University of Bonn are setting out to develop “mini-organs” in order to study metabolic and disease mechanisms.
yavdat
AI enables first integrated single-cell atlas of the lung
15.06.2023
Can a human organ be mapped on a single-cell level to learn more about each individual cell? And can we learn how different these cells are from person to person? Helmholtz Munich researchers and their collaborators have taken up this challenge and developed the Human Lung Cell Atlas using artificial intelligence (AI)-based techniques.
Jens Meyer/Uni Jena
Specially coated titanium reduces risk of clots on prostheses
26.05.2023
An international research team led by the german University of Jena has now developed a promising approach to significantly reducing blood clotting on the heart valve material titanium.
WFIRM
Bioprinting research makes history when it soars to the ISS
17.05.2023
The Wake Forest Institute for Regenerative Medicine (WFIRM) will make history this month when the first bioprinted solid tissue constructs soar to the International Space Station (ISS) on board the next all private astronaut mission by commercial space leader Axiom Space.
European Cooperation in Science and Technology
Imaging chronic kidney disease
12.05.2023
Magnetic Resonance Imaging (MRI) has shown a high potential to distinguish biomarkers for CKD, but renal MRI biomarkers are currently underused in research and clinical practice.
Pekka Ruusuvuori
AI-based method to replace chemical staining of tissue
21.04.2023
Researchers have developed an artificial intelligence-based method for virtual staining of histopathological tissue samples as a part of the Nordic ABCAP consortium.
Max Planck Institute for Molecular Biomedicine
Microelectrode array: hammock for brain organoids
20.04.2023
Novel microelectrode array system enables long-term cultivation and electrophysiological analyses of brain organoids.
Fraunhofer-Translationszentrum/Fraunhofer ISC
SAPs4Tissue: human tissue models with customized biomaterials
12.04.2023
In a joint project of the Max Planck Institute for Polymer Research, Mainz, and the Translational Center for Regenerative Therapies at the Fraunhofer Institute for Silicate Research ISC, Würzburg, scientific principles and biomaterials for the standardized production of valid tissue models are to be developed.
HIPS/Boese
New cell model for the human lung
16.02.2023
A team led by Prof Claus-Michael Lehr of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has developed a novel human lung cell line that should enable much more accurate predictions of the behavior of active substances or dosage forms in humans than previous systems.
CC BY-SA 2.0.
More accurate way of checking the blood flow in the feet of patients with type 2 diabetes
15.02.2023
Aston University scientists have discovered a more accurate way of checking the blood flow in the feet of patients with type 2 diabetes.
PeterHermesFurian
"Spleen-on-a-chip" yields insight into sickle cell disease
06.02.2023
With this microfluidic device, researchers modeled how sickled blood cells clog the spleen’s filters, leading to a potentially life-threatening condition.
Osaka Metropolitan University
Realtime monitoring with wearable reveals IBS-related changes
18.01.2023
Associate Professor Fumio Tanaka and his research group at the Osaka Metropolitan University Graduate School of Medicine recorded the autonomic nervous system activity of IBS patients and healthy subjects using a wearable device and tracked activities such as defecation and sleep.
Amac Garbe/Fraunhofer IWS
Radioactive substances fight cancer in the mini-lab
13.01.2023
Two Dresden research institutes want to reduce the number of animal experiments in radiopharmaceutical research with a new idea.
PantherMedia/benschonewille
Technology against organ shortage – Support for the successful transplant
03.02.2022
The waiting time for a donor organ is long nowadays since the need for organs vastly exceeds their availability. But we have possibilities to improve the situation and help as many people as possible to survive despite organ failure: Some organ functions can already be substituted by technology. But medicine is also researching ways to make more organs available for transplant.
PantherMedia/NikD51
Donor organs: Solving the shortage with technology
03.01.2022
Patients waiting for a donor organ must have a lot of patience and a bit of luck. Aging and a rise in chronic disease prevalence means the need for donor organs is much greater than the number that is available. To help those who need organ transplants, scientists must create new technologies.
Charité – Universitätsmedizin Berlin
Machine Perfusion: Increasing the Safety of Marginal Organ Transplants
03.01.2022
The shortage of donor organs is a major global issue. An aging population, a reluctance towards organ donation, and logistical challenges related to organ shipping play an important role in this setting. Machine perfusion can be a way to expand and preserve the donor pool for eligible transplant recipients.
Karin Kaiser / MHH
New X-ray technique shows vascular damage in intact COVID-19 lungs for first time
05.11.2021
When the coronavirus enters the lung, it causes massive tissue damage. Now, an international research team has been able to demonstrate for the first time, using a highly innovative X-ray technique in a non-destructive manner, that severe COVID-19 causes massive remodelling of the finest blood vessels by causing normally separate blood systems to join together with unusual frequency.
Tissue Engineering and Bioprinting – From artificial heart valves and printed humans
27.01.2021
Drug research and artificial skin replacement - these are the areas in which tissue engineering and bioprinting are already used today. What else could be possible in the future? We asked Dr. Nadine Nottrodt from Fraunhofer ILT and Prof. Sabine Neuß-Stein from RWTH Aachen University Hospital!
Bioprinting: life from the printer
01.12.2020
It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
"Cells are highly sensitive" – material development for bioprinting
01.12.2020
The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
Multi-photon lithography: printing cells with micrometer accuracy
01.12.2020
How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
Printed life – possibilities and limits of bioprinting
01.12.2020
Implants, prostheses and various other components made of plastic, metal or ceramics are already being produced by additive manufacturing. But skin, blood vessels or entire organs from the printer – is that possible? For years now, intensive research has been underway into the production of biologically functional tissue using printing processes. Some things are already possible with bioprinting.
Regenerative medicine: helps the body healing
03.02.2020
Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
Angiogenesis: light shows blood vessels the way
03.02.2020
Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
Regenerative medicine: creating a new body?
03.02.2020
Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
panthermedia.net/phonlamai
A new type of endoscopy – small, easy, comfortable
22.01.2020
Patients have to undergo a gastroscopy to rule out gastrointestinal conditions. Many dread this procedure since a thin, flexible tube is being pushed through the esophagus and stomach. Ovesco Endoscopy AG has teamed up with other project partners in the nuEndo research project to develop a capsule endoscopy device that is tiny, easy to swallow and makes the test more comfortable for the patient.
Endoprosthetic surgery: modern and traditional approaches
01.01.2020
Surgery is required if you need an artificial joint. Patients and doctors must select the type of surgery that’s best suited and choose between robot-assisted, traditional or minimally invasive surgical approaches. Post-operative risks should be kept to a minimum, while benefits should outweigh any possible complications.
APRICOT-project: implant "help(s) patients heal themselves"
01.01.2020
Today, people tend to live longer, while an increasing number of patients suffer from osteoarthritis. Even younger generations are now at a higher risk of getting osteoarthritis due to the frequent use of mobile devices. The EU research project APRICOT aims to develop a novel type of implant for the treatment of osteoarthritis of the hands – helping patients heal themselves.
panthermedia.net/olanstock
Cardiac diagnostics – prompt and personalized
08.11.2019
If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
panthermedia.net/kasto
Cardiac Tissue Engineering: a heart out of the Petri dish
23.09.2019
For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
Multi-organ chips: Drug research without animal testing at vasQlab
15.05.2019
New active substances that are suitable for drugs are initially tested in animal experiments. However, the results cannot always be transferred to the human organism. At the Karlsruhe Institute of Technology, Prof. Ute Schepers from vasQlab explains how active substances can be tested in human tissue without endangering human health.
Restoring Pulmonary Function
01.03.2019
People suffering from lung disease temporarily need ventilator support because they are unable to breathe naturally. Mechanical ventilation is designed to ensure the survival of these patients. The goal is to adapt the ventilator settings and tailor them the patient's specific needs and prevent lung tissue damage.
Fraunhofer ITEM/Till Holland
Gentle medication for the little ones – with every breath
22.02.2019
According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
Organ-on-a-chip – Organs in miniature format
01.02.2019
In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
Multi-Organ Chips – The Patients of Tomorrow?
01.02.2019
The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.