Harnessing light to control cellular dynamics
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Image: Man sitting before a monitor showing data from a microscope in the foreground while a woman in the background is looking through a microscope; Copyright: MPIKG

MPIKG

Harnessing light to control cellular dynamics

23.05.2024

Researchers led by Rumiana Dimova at the Max Planck Institute for Colloids and Interfaces have developed a technique that uses light to understand and control the inner dynamics of cells. By employing lights of different colors, they can alter the interactions within cellular components, offering a precise and non-invasive method to administer drugs directly into the cells.
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Image: Optical coherence tomography in black and white; Copyright: LaNCE-Neuropharm - GIC 21/133

LaNCE-Neuropharm - GIC 21/133

Predicting cognitive progression in parkinson's patients

22.05.2024

A recent study conducted by the University of the Basque Country (UPV/EHU) and Biobizkaia sheds light on a potential breakthrough in Parkinson's disease research. The study suggests that analyzing retinal thickness could serve as a predictive tool for cognitive progression in Parkinson's patients, offering new avenues for monitoring neurodegeneration.
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Image: A Fraunhofer IWS laboratory device is held by a person in blue gloves; Copyright: minkus-images.de/Fraunhofer IWS

minkus-images.de/Fraunhofer IWS

Insights into the development of metastases with miniature laboratories

22.04.2024

New developments at the Fraunhofer Institute for Material and Beam Technology IWS and partners enable improved research possibilities for cancer therapy using microphysiological systems.
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Image: A man looks through a microscope in the foreground, while a woman stands in the background and explains something to him; Copyright: Messe Düsseldorf/Andreas Wiese

Messe Düsseldorf/Andreas Wiese

World Laboratory Day: Laboratory medicine in transition

16.04.2024

World Laboratory Day takes place annually on April 23. It is intended to draw attention to the work in laboratories and the achievements of laboratory employees. MEDICA-tradefair.com takes the day as an opportunity to highlight current trends that continue to shape these work environments. These trends will also be a main focus of the MEDICA LABMED FORUM at MEDICA 2024.
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Image: There is a machine with a microscope. On the right side of the picture, there is a screen; Copyright: Fraunhofer ILT, Aachen, Germany

Fraunhofer ILT, Aachen, Germany

Advanced cell sorting with laser and AI

25.03.2024

The Fraunhofer Institutes for Laser Technology ILT and for Production Technology IPT developed a new AI-assisted high-throughput process that enhances cell isolation. This presents vast implications for personalized medicine, drug development, and clinical research.
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Image: Close-up and 3D illustration of cream-colored molecules on a black background; Copyright: Determined

Determined

A sugar analysis could reveal different types of cancer

22.12.2023

In the future, a little saliva may be enough to detect an incipient cancer. Researchers at the University of Gothenburg have developed an effective way to interpret the changes in sugar molecules that occur in cancer cells.
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Image: Private lecturer Dr. Jonas Schupp sits next to a microscope and smiles for the camera; Copyright: privat

privat

Chronic lung diseases: funding for precision medicine

20.12.2023

Associate Professor Dr Jonas Schupp receives funding for his research into chronic lung diseases.
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Image: Dr Tabea Seeliger and Professor Dr Thomas Skripuletz: Utensils for taking tear and saliva samples; Copyright: Karin Kaiser/MHH

Karin Kaiser/MHH

MS and Sjögren's: the same and yet different

13.12.2023

MHH project investigates differences in neurological symptoms between multiple sclerosis and the rare Sjögren's syndrome.
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Image: Eye test, machine and a woman for optometric assistance, retinal scanning or optical surgery in a clinic.; Copyright: YuriArcursPeopleimages

YuriArcursPeopleimages

Eye scans provide crucial insights into kidney health

08.12.2023

3D eye scans can reveal vital clues about kidney health that could help to track the progression of disease, research suggests. The advance could revolutionise monitoring of kidney disease, which often progresses without symptoms in the early stages.
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Image: Optical resolution of the latest super-resolution microscopy methods on biomolecules: artistic diagram; Copyright: Universität Würzburg

Universität Würzburg

PicoRuler: Molecular rulers for high-resolution microscopy

06.12.2023

A team from the Rudolf Virchow Zentrum – Center for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, led by Dr Gerti Beliu and Professor Markus Sauer, presents a groundbreaking advance for the world of high-resolution fluorescence microscopy.
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Image: Three men stand in the UCD Conway Institute; Copyright: Vincent Hoban, University College Dublin

Vincent Hoban, University College Dublin

World’s first commercial deployment of novel soft X-ray microscope

03.11.2023

SiriusXT Ltd, an Irish technology SME, announced the world’s first commercial deployment of the SXT-100, the company’s unique table-top Soft X-ray Microscope with applications in disease research and the drug discovery process, at the UCD Conway Institute of Biomolecular and Biomedical Research at University College Dublin.
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Image: Image of fluorescently labeled nanoparticles (pink) in human colon cancer cells (green) 24 hours after addition to cell culture; Copyright: umg/Dr. Dolma Choezom

umg/Dr. Dolma Choezom

Project CANACO: better imaging-based and targeted therapy of colon cancer

01.11.2023

The University Medical Center Göttingen (UMG) is coordinating the development of a new nanoparticle-based method for the personalized therapy of patients suffering from colon cancer.
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Image: Symbolic image: colored contrasting lines in blue and violet on a white background; Copyright: alexlucru123

alexlucru123

Novel nanoparticles could serve as contrast agents

27.10.2023

Special nanoparticles could one day improve modern imaging techniques. Developed by researchers at Martin Luther University Halle-Wittenberg (MLU), the properties of these unique nanoparticles change in reaction to heat.
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Image: 3D illustration of red and elongated Mycobacterium tuberculosis; Copyright: iLexx

iLexx

Why tuberculosis bacteria form long chains

25.10.2023

A researcher team from Ecole Polytechnique Federal de Lausanne led by Dr. Vivek Thacker now group leader at the Department of Infectious Diseases at Heidelberg University Hospital have studied why tuberculosis bacteria form long strands and how this affects their infectivity.
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Image: Diagram of synapse formation: Glowing protein shows the development of synaptic vesicles; Copyright: Barth van Rossum, FMP

Barth van Rossum, FMP

Microscopy and fluorescence show how synapses are formed

23.10.2023

How are synapses formed, those points of contact that allow the transmission of information from one neuron to the other? Working with an international team, researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have now uncovered a crucial mechanism and elucidated the identity of the axonal transport vesicles that generates synapses.
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Image: Uršula Vide from the Institute of Biochemistry at TU Graz working in the lab; Copyright: TU Graz

TU Graz

Light as on-off switch for enzymes

10.08.2023

Researchers at TU Graz have gained new insights into the functioning of a protein found in bacteria, whose enzymatic activity is activated by blue light.
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Image: It shows the activation of a chemical signaling pathway (ERK pathway; top-right) merged with a simulation of 2D cell areas (bottom-left) in a monolayer of cells; Copyright: Hannezo Group | ISTA

Hannezo Group | ISTA

Cell dynamics: how cells talk to each other

26.07.2023

Like us, cells communicate. Well, in their own special way. Using waves as their common language, cells tell one another where and when to move.
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Image: Images of complex brain structures. On the left these structures are difficult to see, on the right they are shown more clearly; Copyright: Johann Danzl

Johann Danzl

Brain: LIONESS enables insights into complex tissue

13.07.2023

In a new paper, an interdisciplinary team of scientists at the Institute of Science and Technology Austria (ISTA) has come together to present a new way to observe the brain’s structure and dynamics – in a high resolution and without damaging the tissue.
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Image: Cross-sectional electron micrographs of individual nerve fibers in MS brain biopsies; Axons sheathed with myelin showing increasingly damage ; Copyright: Leipzig University

Leipzig University

Multiple sclerosis: Myelin may be detrimental to nerve fibres

05.07.2023

Researchers at Leipzig University and Max Planck Institute for Multidisciplinary Sciences in Göttingen have discovered that myelin, which was previously thought to be solely protective, can actually threaten the survival of the axons.
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Image: Depiction of a brain and the nerve connections that run down the spinal cord; Copyright: joaquincorbalan

joaquincorbalan

Fiber-based endo-microscope: understanding neuronal communication

28.06.2023

A new hair-thin endo-microscope, developed by an international team with the participation of Leibniz IPHT, promises extremely gentle in-depth observations.
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Image: Viral Microscope View. 3D illustration of a corona virus in blue color; Copyright: maxxyustas

maxxyustas

Corona: The virus needs only a single door opener

15.06.2023

Why is the SARS-CoV-2 coronavirus able to spread so efficiently? Various hypotheses are still circulating in the scientific community. A group of researchers from Würzburg has now found groundbreaking answers.
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Image: Micrograph: Certain immune cells called microglia (yellow) remove amyloid plaques (magenta) in the brain of an Alzheimer's mouse; Copyright: MPI für Multidisziplinäre Naturwissenschaften

MPI für Multidisziplinäre Naturwissenschaften

Dementia: poorly insulated nerve cells promote Alzheimer's disease in old age

08.06.2023

Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen have shown that defective myelin actively promotes disease-related changes in Alzheimer’s. Slowing down age-related myelin damage could open up new ways to prevent the disease or delay its progression in the future.
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Image: Two women, Wiebke Möbius and Sophie Hümmert, at a white electron microscope; Copyright: Swen Pförtner MPI

Swen Pförtner MPI

Multiple Sclerosis: structural changes in brain tissue promote inflammatory processes

31.05.2023

A German-Dutch research team has shown that ultrastructural changes in healthy areas in the white matter of MS patients make the tissue more susceptible to inflammation and the formation of lesions
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Image: A man in a gray jacket and white shirt, Miroslaw Bober, smiles at the camera; Copyright: University of Surrey

University of Surrey

UK AI world leader in identifying location and expression of proteins

18.05.2023

A new advanced artificial intelligence (AI) system has shown world-leading accuracy and speed in identifying protein patterns within individual cells.
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Image: Microscopic image of bone-marrow cells of a multiple myeloma patient.; Copyright: Berend Snijder Lab / ETH Zurich

Berend Snijder Lab / ETH Zurich

How to fight blood cancer more effectively

05.05.2023

Despite approved treatments being available, multiple myeloma remains incurable. But researchers at ETH Zurich and University Hospital Zurich set out to improve treatment outcomes by testing hundreds of existing therapeutics outside the body to predict their effectiveness.
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Image: 3D-segmentation of different structures related to an infection with the Ebola virus.; Copyright: Petr Chlanda

Petr Chlanda

Luring the virus into a trap

04.05.2023

Heidelberg researchers describe mechanisms that could help prevent infections with the influenza A and Ebola viruses.
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Image: A Setup to conduct Optical Nanomotion Detection, b Optical image of E. coli bacteria. C. Same field of view as B in false colors; Copyright: Ines Villalba (EPFL)

Ines Villalba (EPFL)

Antibiotic resistance: fast, cheap, and easy test method

02.05.2023

“We have developed a technique in our laboratories that allows us to obtain an antibiogram within 2-4 hours – instead of the current 24 hours for the most common germs and one month for tuberculosis,” says Dr Sandor Kasas at EPFL.
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Image: An example of virtual staining of tissue. Unstained tissue on the left, chemically stained tissue in the middle and virtually stained tissue on the right; Copyright: Pekka Ruusuvuori

Pekka Ruusuvuori

AI-based method to replace chemical staining of tissue

21.04.2023

Researchers have developed an artificial intelligence-based method for virtual staining of histopathological tissue samples as a part of the Nordic ABCAP consortium.
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Image: medical syringe lies on several doses of vaccine; Copyright: erika8213

erika8213

AI meets zebrafish: is this the future of drug discovery?

04.04.2023

New drug candidates must undergo lengthy testing using animal models before being given to participants in human trials. This means many active ingredients must already be sorted out in test series because they either do not have the desired or even have an adverse effect. These test series require many test animals. The use of zebrafish larvae could lead to a reduced demand in this setting.
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Image: Detailed measurement of how the motor protein kinesin-1 (red) walks on microtubules (white); Copyright: Max-Planck-Institut für medizinische Forschung

Max-Planck-Institut für medizinische Forschung

Further advance in super-resolution fluorescence microscopy

16.03.2023

Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
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Image: Close-up of a scientist wearing protective clothing looking through a microscope; Copyright: ckstockphoto

ckstockphoto

Smart microscopy works out where to take the picture

16.03.2023

Researchers at Lund University in Sweden have now developed a software solution for smart, data-driven microscopy, which makes this possible.
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Image: Young female scientist in protective mask and glasses examining chemical or biological sample with microscope in laboratory; Copyright: Pressmaster

Pressmaster

AI analyses cell movement under the microscope

22.02.2023

The enormous amount of data obtained by filming biological processes using a microscope has previously been an obstacle for analyses.
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Image: During their journey through the blood, blood proteins accumulate on the surface of nanoparticles. 3D illustration; Copyright: MPI-P

MPI-P

New insights into the utilization of nanotechnology-based drugs

01.02.2023

Scientists at the Max Planck Institute for Polymer Research have now followed the path of such a particle into a cell using a combination of several microscopy methods. They were able to observe a cell-internal process that effectively separates blood components and nanoparticles.
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