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Image: Two researchers are standing side by side, smiling for a photo in a bright corridor with windows, likely within a university or research facility; Copyright: CHUM

CHUM

Liver cancer treatment: Utilizing magnetic field-guided microrobots

12.04.2024

A new medical technique utilizing magnet-guided microrobots for treating liver tumors has been developed by a Canadian research team, offering a potential new approach in oncology.
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Image: Close-up of the surgeon's hands during an operation

Wound closure: soldering with light and nanotechnology

02.04.2024

With "iSoldering", the Particles Biology Interactions Laboratory at the Swiss Federal Laboratories for Materials Science and Technology (Empa) in St. Gallen and the Nanoparticle Systems Engineering Laboratory at ETH Zurich have developed a method that does not require surgical sutures or synthetic adhesives. Instead, nanoparticles and light enable secure wound closure.
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Image: In the foreground, there is a testing sample held by a tweezer. In the background, a woman is looking at the sample; Copyright: HZDR / Anja Schneider

HZDR / Anja Schneider

HZDR team introduces novel pathogen detection approach

12.03.2024

Detecting diseases early or predicting their onset is crucial for healthcare. Dr. Larysa Baraban's team at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) develops miniaturized biosensor devices using nanomaterials.
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Image: Two people in a laboratory working with a nanoparticle paste and light. Copyright: Empa

Empa

Smart wound sealing with nanoparticles and light soldering

24.01.2024

Empa researchers have pioneered a novel soldering process that employs nanoparticles and lasers to gently fuse tissue, ushering in a new era in wound closure.
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Image: Optical resolution of the latest super-resolution microscopy methods on biomolecules: artistic diagram; Copyright: Universität Würzburg

Universität Würzburg

PicoRuler: Molecular rulers for high-resolution microscopy

06.12.2023

A team from the Rudolf Virchow Zentrum – Center for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, led by Dr Gerti Beliu and Professor Markus Sauer, presents a groundbreaking advance for the world of high-resolution fluorescence microscopy.
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Image: Anatomical model of human pancreatitis; Copyright: JoPanwatD

JoPanwatD

Pancreas: nanoparticles for optimized cancer therapy

23.11.2023

Researchers from Göttingen and Karlsruhe have developed a new treatment approach for pancreatic cancer. The innovative method promises to be able to treat the disease in a more targeted way and with fewer side effects in the future. The therapy is now to be optimized for clinical application as quickly as possible.
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Image: Image of fluorescently labeled nanoparticles (pink) in human colon cancer cells (green) 24 hours after addition to cell culture; Copyright: umg/Dr. Dolma Choezom

umg/Dr. Dolma Choezom

Project CANACO: better imaging-based and targeted therapy of colon cancer

01.11.2023

The University Medical Center Göttingen (UMG) is coordinating the development of a new nanoparticle-based method for the personalized therapy of patients suffering from colon cancer.
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Image: Symbolic image: colored contrasting lines in blue and violet on a white background; Copyright: alexlucru123

alexlucru123

Novel nanoparticles could serve as contrast agents

27.10.2023

Special nanoparticles could one day improve modern imaging techniques. Developed by researchers at Martin Luther University Halle-Wittenberg (MLU), the properties of these unique nanoparticles change in reaction to heat.
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Image: Close up: A new wearable sensor to monitor glucose levels in sweat; Copyright: Kate Myers/Penn State

Kate Myers/Penn State

Wearable sensor for continuous analysis of sweat

06.10.2023

Continuous monitoring of sweat can reveal valuable information about human health, such as the body’s glucose levels. However, wearable sensors previously developed for this purpose have been lacking, unable to withstand the rigors or achieve the specificity needed for continuous monitoring, according to Penn State researchers.
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Image: The MinION device connected to a computer. The screen shows data from the evaluation; Copyright: Oxford Nanopore

Oxford Nanopore

Nanopore sequencing and DNA barcoding method gives hope of personalised medicine

03.10.2023

With the ability to map dozens of biomarkers at once, a new method could transform testing for conditions including heart disease and cancer.
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Image: Dr. Marina Dziuba in the laboratory with bacterial cultures to produce magnetic nanoparticles; Copyright: Christian Wißler/UBT

Christian Wißler/UBT

EXIST funding for bacterial magnetic nanoparticles

28.09.2023

BioMagnetix uses bacterial magnetic nanoparticles as innovative materials for biomedical applications. The founding team aims to develop and continuously improve high-quality and highly functional magnetic nanoparticles for imaging techniques and therapeutic purposes, such as cancer treatment.
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Image: Schematic structure of a sensor for the detection of viral pathogens; Copyright: TUD

TUD

Diagnostics: pioneering approaches for the detection of viral antigens

22.09.2023

Scientists from the Chair of Materials Science and Nanotechnology at TU Dresden (TUD) have made considerable progress in the development of highly innovative solutions for the detection of viral pathogens in two studies they presented recently.
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Image: Close-up of microtiter plates that are filled with several pipettes; Copyright: LMU

LMU

Immunotherapy: Antibody kit to fight tumors

25.08.2023

A new study highlights the potential of artificial DNA structures that, when fitted with antibodies, instruct the immune system to specifically target cancerous cells.
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Image:Upon irradiation by near infra-red light, Anti-PD-L1 specifically binds to the cancer cell, while immunostimulants activate T and dendritic cells; Copyright: Eijiro Miyako from JAIST

Eijiro Miyako from JAIST

Cancer photoimmunotherapy: novel liquid metal nanoparticles

10.08.2023

JAIST researchers create liquid metal nanoparticles (PEG-IMIQ-LM) for cancer treatment, merging photothermal therapy and immunotherapy. Disintegration delivers immunomodulants and tracks cancer cells in real-time. Immune checkpoint inhibitor enhances cancer removal. Promising for future cancer theranostics, with clinical trials anticipated in a decade.
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Image: Magnetic nanoparticles (red) bind specifically to the spherical bacteria (yellow) which are about 1 µm in size (electron microscopy digitally colored); Copyright: Empa

Empa

Antibiotics crisis: rapid test for sepsis with nanoparticles

09.06.2023

For Qun Ren, every minute counts. The Empa researcher and her team are currently developing a diagnostic procedure that can detect life-threatening blood poisoning caused by staphylococcus bacteria rapidly. This is because staphylococcal sepsis is fatal in up to 40 percent of the cases.
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Image: 3D render of the tibias treated with the current clinical treatment option chemotherapeutics or treated with chemotherapeutics plus gene therapy; Copyright: UCD Research and Innovation

UCD Research and Innovation

Novel combination of therapies may provide new treatment option for bone cancer

03.05.2023

New research has identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer that primarily affects children and adolescents.
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Image: Close-up of doctor pointing at human pelvic skeleton model in medical clinic.; Copyright: Okrasyuk

Okrasyuk

Map of spinal cord formation gives new knowledge on diseases of the nervous system

03.05.2023

Researchers at Karolinska Institutet in Sweden have mapped how cells in the human spinal cord are formed in the embryo and what genes control the process.
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Image: Johannes Karges smiles for the camera in a light blue shirt and dark blue jacket. In the background is a green area; Copyright: RUB, Marquard

RUB, Marquard

Ultrasound activates anticancer agent

14.04.2023

Chemotherapy treatments produce strong side effects. A new agent that accumulates in the tumour tissue and is activated there by ultrasound waves does not have this problem.
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Image: Dr Ioana Slabu and Benedict Bauer with the nanomodified stent fot he camera; Copyright: Peter Winandy

Peter Winandy

Novel technology for hollow organ tumour therapy

10.04.2023

Ioana Slabu from the Institute of Applied Medical Technology and Benedict Bauer from the Institut für Textiltechnik of RWTH Aachen University have developed a novel technology for the therapy of hollow organ tumours, which was awarded second place in the RWTH Innovation Award.
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Image: Picture of the complete sensor with a PDMS well of 100 μl volume for the drop test; Copyright: HZDR/Sandoval Bojorquez

HZDR/Sandoval Bojorquez

Nanobiosensor developed for detecting SARS-CoV-2

04.04.2023

Infection and immunity status of the population are considered key parameters for handling pandemics. For this purpose, detecting antigens and antibodies is of great importance. The devices currently used for this purpose - what are known as point-of-care (POC) devices- are one option for rapid screening. Their sensitivity, however, needs further improvement.
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Image: Close-up of a sample tray and analyzer in the laboratory; Copyright: Fraunhofer IPK / Larissa Klassen

Fraunhofer IPK / Larissa Klassen

New technologies for producing mRNA-based pharmaceuticals

24.03.2023

Together with partners from science and industry, Fraunhofer IPK is researching how mRNA therapeutics and other medication can be better produced and more effectively applied.
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Image: Detailed measurement of how the motor protein kinesin-1 (red) walks on microtubules (white); Copyright: Max-Planck-Institut für medizinische Forschung

Max-Planck-Institut für medizinische Forschung

Further advance in super-resolution fluorescence microscopy

16.03.2023

Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond.
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Image: Two men in dark clothes posing in front of the experimental station Alvra of the Swiss X-ray free-electron laser SwissFEL; Copyright: Paul Scherrer Institut/Markus Fischer

Paul Scherrer Institut/Markus Fischer

Using light to switch drugs on and off

27.02.2023

In the ImageTox project, the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the CISPA Helmholtz Center for Information Security are pooling their expertise in the fields of drug discovery and artificial intelligence (AI).
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Image: The project team, consisting of 15 people, poses in front of a gray wall; Copyright: The Project Team / Claudia Pock

The Project Team / Claudia Pock

Multinational research consortium to advance nanomedicine manufacturing

15.02.2023

Gattefossé, InProcess-LSP, Knauer, Microfluidics, Skyepharma, and the University of Graz join the RCPE-led European Consortium for Continuous Pharmaceutical Manufacturing (ECCPM) to jointly develop a modular, flexible toolkit to advance industrial-scale production of lipid nanoparticles.
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Image: Illustration of the nanomaterial graphene with gold nano disks array; Copyright: NTNU

NTNU

Super quick COVID test uses new technology

13.02.2023

The ability of gold particles to reflect light in different colours is used in applications from stained glass to pregnancy tests. Now researchers are set to exploit the same properties in an ultra-fast sensor for the coronavirus.
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Image: A woman with black hair in a white coat sits in a research laboratory and operates a microscope; Copyright: wichayada69

wichayada69

Funding to produce biodegradable antiviral and antibacterial materials

08.02.2023

A new junior research group at Freie Universität Berlin, which will investigate the production of biodegradable antiviral and antibacterial materials, with one of the goals of synthesis being new alternatives to conventional antibiotics, will receive a total budget of more than 1.8 million euros from the German Federal Ministry of Education and Research (BMBF) over the next five years.
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Image: During their journey through the blood, blood proteins accumulate on the surface of nanoparticles. 3D illustration; Copyright: MPI-P

MPI-P

New insights into the utilization of nanotechnology-based drugs

01.02.2023

Scientists at the Max Planck Institute for Polymer Research have now followed the path of such a particle into a cell using a combination of several microscopy methods. They were able to observe a cell-internal process that effectively separates blood components and nanoparticles.
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Image: Test tubes with blood for checking antibodies in the fridge; Copyright: lorenzocapunata

lorenzocapunata

When antibodies do a pirouette

12.01.2023

Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Julius-Maximilians-Universität Würzburg have developed a method for binding specific molecules in samples and serums, such as antibodies in the blood, to the surface of iron oxide particles thus allowing them to be identified using an inexpensive and compact detector.
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Image: Position of molecules on nanoparticle surfaces as a 3D illustration; Copyright: Max-Planck-Institut für Polymerforschung

Max-Planck-Institut für Polymerforschung

How optical microscopes allow detailed investigations of nanoparticles

06.01.2023

In their project "Supercol"- funded by the European Union - scientists want to achieve the investigation of nanoparticles with light.
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Image: Scientist works with medical test tube to analyze green liquid; Copyright: DC_Studio

DC_Studio

Diagnosing breast cancer through liquid biopsy

22.09.2022

Breast cancer diagnosis usually includes invasive testing with tissue biopsies. The samples have to be extracted from the cancerous tissue or cells. To make the process easier on the patients, the project LIBIMEDOTS is currently developing a different approach with liquid biopsy technology.
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Image: The researchers incorporated their sensor into a prototype with a fiber optic tip that can detect changes in fluorescence in the test sample; Copyright: MIT

MIT

Carbon nanotube-based sensor can detect SARS-CoV-2 proteins

26.10.2021

Using specialized carbon nanotubes, MIT engineers have designed a novel sensor that can detect SARS-CoV-2 without any antibodies, giving a result within minutes. Their new sensor is based on technology that can quickly generate rapid and accurate diagnostics, not just for Covid-19 but for future pandemics, the researchers say.
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Image: Ion track nanotechnology from GSI Materials Research creates a highly sensitive nanopore.; Copyright: GSI/FAIR

GSI/FAIR

New sensor for SARS-CoV-2 and other viruses based on GSI nanotechnology

12.10.2021

Easy and fast detection of viruses are crucial in a pandemic. Based on single-nanopore membranes of GSI, an international interdisciplinary team of researchers developed a test method that detects SARS-CoV-2 in saliva, without sample pretreatment, with the same sensitivity as a qPCR test, and in only 2 hours. On top, the sensor can distinguish infectious from non-infectious corona viruses.
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Image: Artist’s rendering of small robots with grapplers and searchlights that swim between red blood cells; Copyright: PantherMedia/Andreus

Autonomous medical technology: independently in the body

01.02.2021

Therapies need to be carried out with high reliability by trained personal. This will not change in the future. But maybe we will be able to let systems in the patient’s body do some of the work. Some approaches are already aiming to make implants more independent so they will be able to flexibly react to changes. Read more in our Topic of the Month!
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Image: Artist’s rendering of small star-shaped machines between red blood cells; Copyright: PantherMedia/Michael Osterrieder

Autonomous medical devices: running well in your body

01.02.2021

In theory, autonomous medical technologies can be used in a diagnostic or therapeutic capacity inside the body under certain conditions. This may not sound like a new invention at first. After all, implantable cardioverter-defibrillators have monitored and fixed abnormal heart rhythm for many years.
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Image: The new medical device Magnetic Particle Imaging (MPI); Copyright: IBI

Molecular Imaging: fast and reliable stroke detection

02.06.2020

After a stroke, a patient’s life depends on getting acute care at a hospital. Vital monitoring systems ensure safe and effective treatment. An innovative tomographic imaging system is designed to help prevent the patient’s risky journey to radiology and to enable bedside monitoring of cerebral blood flow.
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