14.02.2020Scientists and physicians have long known that immune cells migrate to the site of an infection, which individuals experience as inflammation - swelling, redness and pain. Now, Northwestern University and University of Washington researchers have uncovered new evidence that this gathering is not just a consequence of immune activation.
11.02.2020Leaky gut is most often experienced by older people, patients with cancers or other chronic ailments, and people with especially stressful lifestyles. Stressors break down the zipper-like junctions between the cells that form the gut lining. Microbes and molecules that subsequently leak out through these cell gaps can trigger an immune response, contributing to a variety of diseases.
05.02.2020Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and partners in Hungary have studied the response to targeted leukemia therapy in unprecedented detail, using single-cell sequencing and epigenetic analysis.
04.02.2020Melding the genetic and cellular analysis of tumors with how they appear in medical images could give physicians and other cancer therapy specialists new insights into how to best treat patients, especially those with brain cancer, according to a new study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.
03.02.2020Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
03.02.2020In rodent studies, a new method reduced likelihood of further spinal cord trauma while delivering large doses of potentially reparative stem cells. This approach may have utility for multiple neurodegenerative conditions.
03.02.2020Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
24.01.2020The damage visible and infrared light can do to our skin has been revealed for the first time in new research by scientists at Newcastle University, UK. The detrimental effects of exposure to the sun's rays are well documented, and the main aim of sunscreens is to protect the skin against dangerous ultraviolet radiation (UV).
22.01.2020Eye-opening study from Cincinnati Children's suggests that lack of sun can lead to problems beyond seasonal affective disorder. Yes, fat cells deep under your skin can sense light. And when bodies do not get enough exposure to the right kinds of light, fat cells behave differently.
21.01.2020A new type of scan that involves magnetising molecules allows doctors to see in real-time which regions of a breast tumour are active, according to research funded by Cancer Research UK and published in Proceedings of the National Academy of Sciences.
21.01.2020Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials. These nanocomposites can be tailored to various applications and programmed to degrade quickly and gently.
13.01.2020Researchers at Osaka University used electron cryomicroscopy (CryoEM) to image essential cardiac muscle components, known as thin filaments, with unprecedented resolution. They also discovered the mechanism by which these filaments regulate heartbeat via cardiac muscle contractions in the presence or absence of calcium ions by changing their conformations.
08.01.2020Doctors have used focused ultrasound to destroy tumors without invasive surgery for some time. However, the therapeutic ultrasound used in clinics today indiscriminately damages cancer and healthy cells alike.
20.12.2019An international team of brain researchers achieved a breakthrough in uncovering a switch-like mechanism that flips the brain between two motivational states in larval zebrafish, a model organism in neuroscience. How the brain switches between states is a central mystery in neuroscience.
20.12.2019Columbia scientists have captured the first images of a new gene editing tool that could improve upon existing CRISPR-based tools. The team developed the tool, called INTEGRATE, after discovering a unique "jumping gene" in Vibrio cholerae bacteria that could insert large genetic payloads in the genome without introducing DNA breaks.
18.12.2019Researchers at the University of Zurich have discovered a protein that enables adenoviruses to infect human cells. The Mib1 protein gives the virus the signal to uncoat the DNA and release it into the nucleus. Blocking this protein could therefore help people with weakened immune systems to fight dangerous viruses.
17.12.2019Up to now, the best tool that provides anatomical, functional, and molecular information of human and animal is the photoacoustic microscopy. Super-resolution localization photoacoustic microscopy which is 500 times faster than the conventional photoacoustic microscopy system is developed by the research team from POSTECH in Korea.
13.12.2019Scientists are developing a new way to identify the unique chemical 'fingerprints' for different types of breast cancers. These new chemical footprints will be used to train AI software - creating a new tool for rapid and accurate diagnosis of breast cancers.
13.12.2019UNC School of Medicine researchers created an artificial intelligence tool to measure NETosis, an inflammatory process where white blood cells trap invaders; this work will help scientists find ways to stop or promote NETosis in disease states
11.12.2019Much remains unknown about diseases and the way our bodies respond to them, in part because the human genome is the complete DNA assembly that makes each person unique. A Virginia Tech professor and his team of researchers have created new technology to help in understanding how the human body battles diseases.
11.12.2019UT Southwestern researchers have developed a software tool that uses artificial intelligence to recognize cancer cells from digital pathology images - giving clinicians a powerful way of predicting patient outcomes.
10.12.2019A new technique overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.
09.12.2019Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older. Arising from the inner surface, or muscosal layer, of the colon, cancerous cells can penetrate through the deeper layers of the colon and spread to other organs. Left untreated, the disease is fatal.
06.12.2019Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix.
26.11.2019Around 60 international experts met on November 7 at the Fraunhofer Institute for Silicate Research ISC in Wuerzburg to report on the state of the art in the field of 3D tissue models and prevention of animal experiments in the development of pharmaceuticals and medical devices.
08.10.2019The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
01.02.2019In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
01.02.2019The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
01.02.2019Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
21.11.2018Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
09.07.2018People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
22.06.2018A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
23.04.2018A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
01.03.2018Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
22.02.2018Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
08.01.2018Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
22.08.2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
14.07.2017A microscope that is only a few millimeters in size and that can help to consider cell changes in real time. This is the goal of the EU project ChipScope. Scientists led by Dr. Hutomo Wasisto in Braunschweig help to make this project come true.