Endoprotheses: between possibility and reality -- MEDICA - World Forum for Medicine

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Blood test could identify COVID-19 patients at risk of hyperinflammation

22/10/2020

A new study jointly led by Professor Tom Wilkinson and Dr Tristan Clark of the University of Southampton, has shown a blood test for five cytokines could help predict those at risk of life-threating overstimulation of immune defenses by COVID-19, and potentially tailor their treatment to tackle this.
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Army researchers collaborate on universal antibody test for COVID-19

20/10/2020

Researchers with the U.S. Army Futures Command are part of a team that tested alternative ways to measure COVID-19 antibody levels, resulting in a process that is faster, easier and less expensive to use on a large scale. Their method holds promise for accurately identifying potential donors who have the best chance of helping infected patients through convalescent plasma therapy.
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Links between inflammation and Parkinson's disease

16/10/2020

Around 15 percent of Parkinson's disease cases are related to a known genetic background, out of which mutations in the Parkin and PINK1 genes are among the most frequent ones. Thus, revealing cellular mechanisms which are altered by these mutations is crucial for the development of new therapeutic approaches.
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Microneedles for therapeutic gene delivery

09/10/2020

There is great potential in gene therapy for treating certain types of cancer and genetic defects, immunological diseases, wounds and infections. The therapies work by delivering genes into the patients' cells, which then produce therapeutic proteins to treat the affliction.
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Sensor that rapidly detects COVID-19 infection

05/10/2020

One feature of the COVID-19 virus that makes it so difficult to contain is that it can be easily spread to others by a person who has yet to show any signs of infection. The carrier of the virus might feel perfectly well and go about their daily business–taking the virus with them to work, to the home of a family member, or to public gatherings.
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Artificial lung to support pre-term babies in distress

05/10/2020

An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress. The group has proven the concept using a live piglet, a major step along the route toward approval for use in humans, where the portable device could save many lives and prevent catastrophic damage.
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Memory training for the immune system

02/10/2020

The immune system will memorize the pathogen after an infection and can therefore react promptly after reinfection with the same pathogen. Now, scientists at the University of Würzburg have deciphered new details of this process.
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COVID-19: cheaper and faster testing

24/09/2020

Researchers at Karolinska Institutet have developed a method for fast, cheap, yet accurate testing for COVID-19 infection. The method simplifies and frees the testing from expensive reaction steps, enabling upscaling of the diagnostics. This makes the method particularly attractive for places and situations with limited resources.
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Study takes us a step closer to a universal antibody test for COVID-19

18/09/2020

A new study released by Houston Methodist takes researchers a significant step closer to developing a uniform, universal COVID-19 antibody test. The multicenter collaboration tested alternative ways to measure COVID-19 antibody levels that is faster and easier.
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Low-cost chip for detecting COVID-19 antibodies

11/09/2020

Robust and widespread antibody testing has emerged as a key strategy in the fight against SARS-CoV-2, the virus responsible for the COVID-19 pandemic. However current testing methods are too inaccurate or too expensive to be feasible on a global scale. But now, scientists at the OIST have developed a rapid, reliable and low-cost antibody test.
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Nanobody may prevent COVID-19 infection

09/09/2020

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells. The researchers believe this nanobody has the potential to be developed as an antiviral treatment against COVID-19. The results are published in the journal Nature Communications.
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Detecting small amounts of virus in early infections

02/09/2020

Diagnostic devices that are used at home or in doctors' offices are often not sensitive enough to detect small amounts of a virus that might be present in samples from asymptomatic patients, which can occur in early stage COVID-19.
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Image: Microscopy image of mouse neurons; Copyright: MPI f. Biology of Ageing/ E. Motori

Nerve cells with energy saving program

01/09/2020

Mitochondria are the power plants of our cells and play an important role in providing energy for normal function of the tissues in our body. Nerve cells are particularly dependent on mitochondria for their activity and decreased mitochondrial function is seen in both inherited and more common age-associated forms of degenerative diseases.
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Project "HCA|Organoid": toward a single-cell atlas of human organoids

31/08/2020

HCA|Organoid is a new EU research project that combines single-cell profiling and organoid technology to validate organoids as faithful models of human biology. By creating well-characterized in vitro models of human organs, this resource will enable future discovery-driven and translational research on rare genetic diseases, complex multifactorial diseases, and on cancer.
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COVID-19: asthma may not be a significant risk factor

31/08/2020

A new research letter published online in the Annals of the American Thoracic Society examines whether asthma is a significant risk factor for developing COVID-19 that is severe enough to warrant hospitalization and intubation. According to the Centers for Disease Control and Prevention, individuals with asthma are at higher risk for hospitalization and other severe effects from COVID-19.
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Machine learning tool predicts intestinal disease in premature infants

11/08/2020

Researchers from Columbia Engineering and the University of Pittsburgh have developed a sensitive and specific early warning system for predicting NEC in premature infants before the disease occurs. The prototype predicts NEC accurately and early, using stool microbiome features combined with clinical and demographic information.
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Characterizing regulators of tissue inflammation

11/08/2020

Although macrophages are classified as immune cells functioning in the activation and resolution of tissue inflammation, it is now clear that they are critically involved in a variety of disease processes, such as chronic inflammatory diseases, tumor growth and metastasis and tissue fibrosis.
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Analyses of genome data enables tracking of avian influenza viruses

10/08/2020

An international consortium succeeded in tracking the genesis and spread of new reassortants of avian influenza viruses by the use of mathematical analyses. This large-scale international study has now been published in the scientific journal PNAS (Proceedings of the National Academy of Sciences of the United States of America).
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Lab profiles differentiate MIS-C from COVID-19 in children

06/08/2020

Findings show that MIS-C is a post-infectious syndrome distinct from Kawasaki disease and may help guide treatment decisions.
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Sars-Cov-2: rapid test for the determination of antibodies

31/07/2020

To determine immunity to Sars-Cov-2 and the effectiveness of potential vaccines, the amount of neutralising antibodies in the blood of recovered or vaccinated individuals must be determined. A traditional neutralisation test usually takes two to three days and must be carried out with infectious coronaviruses in a laboratory complying to biosafety level 3.
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Hygiene: Smart protection against pathogens like the coronavirus

23/03/2020

Germs such as bacteria, viruses or pathogenic fungi can spread from one person to another through direct contact when we shake hands or touch objects. People touch door handles and push elevator buttons in public places and constantly move in and out of spaces. Regular manual high-level disinfection is practically impossible. UVentions GmbH has found an intelligent solution for this problem.
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rhCollagen: genetically engineered building block for regenerative medicine

03/02/2020

Collagen is the stuff that holds our bodies together and that houses our cells. In regenerative medicine, it is also the stuff that can be applied to wounds to support healing. However, collagen from animal or human sources has some drawbacks for today’s medicine. This is where rhCollagen from the Israeli company CollPlant comes into play.
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Endoprotheses: between possibility and reality

01.01.2020

When natural joints lose their ability to function, they can be completely or partially replaced by artificial joints, also called endoprotheses. Endoprotheses must be of a certain quality, as they should remain in the body as long as possible. In addition to some risks, endoprotheses can also contribute to a mobile and carefree life for young and old.
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Endoprosthetic surgery: modern and traditional approaches

01/01/2020

Surgery is required if you need an artificial joint. Patients and doctors must select the type of surgery that’s best suited and choose between robot-assisted, traditional or minimally invasive surgical approaches. Post-operative risks should be kept to a minimum, while benefits should outweigh any possible complications.
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Endoprotheses: regaining independence and mobility

01/01/2020

Joints can suddenly or gradually deteriorate and lose their natural strength, whether it’s due to accidents, diseases or simple wear and tear. In some of these cases, implants of artificial joints – endoprostheses - can help. As a joint replacement, they are designed to stay in the body for as long as needed and as such improve the patient’s quality of life and mobility.
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Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04/11/2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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AI software: "iSTIX opens your world to the possibilities of digital pathology"

08/10/2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Antibiotic resistance: technical tricks against pathogens

01/08/2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Sports medicine - performance values in best health

01/07/2019

Those who integrate physical activities into their own lifestyle live healthier and more balanced. But where are the physical limits? Can health status measurements also be carried out on the road? Discover more about how sports medical examinations contribute to maintain performance and minimize health risks in our Topic of the Month.
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Sports medicine – keep moving to stay healthy

01/07/2019

Physical activity plays a big role in today's society. Whether you are an amateur or professional athlete – incorporating exercise into your life positively impacts your mental and physical health. Ideally, sport should be fun, pressure-free and not overburden you. But can you measure individual performance and align it with sports?
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On the trail of cancer: personalized cancer vaccine

01/03/2018

Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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