Functional imaging: a look at the command center -- MEDICA - World Forum for Medicine

Image: response of sickle cells observed under a microscope, on the right the chip next to a coin; Copyright: Florida Atlantic University

Microfluidic sensor: monitoring sickle cell disease

19.06.2019

Sickle cell disease is a hereditary disorder that affects red blood cells, distorting their natural disc shape into a crescent moon or "sickle" shape. Normal red blood cells move freely through small vessels throughout the body to deliver oxygen. With sickle cell disease, the misshapen red blood cells become hard and sticky, making it difficult for them to move through blood vessels.
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Image: cells are placed on a microfluidic organ-chip; Copyright: Dr. Gad Vatine/BGU

Blood-brain barrier chip: using stem cells for the first time

18.06.2019

Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
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Image: different images of an artery; Copyright: Sung Soo Sean Choi et al.

Imaging: new modality targets cholesterol in arterial plaque

18.06.2019

In an article published in the peer-reviewed SPIE publication Journal of Biomedical Optics (JBO), "Frequency-domain differential photoacoustic radar: theory and validation for ultra-sensitive atherosclerotic plaque imaging," researchers demonstrate a new imaging modality that successfully identifies the presence of cholesterol in the arterial plaque.
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Image: microscope images of the human Blood-Brain Barrier-on-Chip; Copyright: Wyss Institute at Harvard University

Blood-Brain Barrier Chip: in vivo-like drug and antibody transport

17.06.2019

Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
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Image: syringe filled with blood; Copyright: panthermedia.net/davoust

World Blood Donation Day: A small drop saves lives

14.06.2019

Donating blood - the World Blood Donation Day has been held annually since 2004 on 14th June, the birthday of Karl Landsteiner, discoverer of blood groups. The day is intended to make people all over the world aware of the relevance of blood donations and donors. But what significance does blood donation have for human health? What activities will take place on this day?
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Image: Bacteria in a petri dish; Copyright: panthermedia.net/alexraths

Bacteriology testing: Bacteria detected in minutes

13.06.2019

A discovery by researchers at the School of Life Sciences at the University of Warwick offers a new technology for detecting bacteria in minutes by `zapping` the bacteria with electricity.
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Image: patient with Parkinson`s playing with a puzzle; Copyright: panthermedia.net/AndrewLozovyi

Ultrasound: restoring dopaminergic pathway at Parkinson's

11.06.2019

While there are several thousand drugs available to treat brain diseases, they cannot penetrate the blood-brain barrier (BBB) into the brain. The BBB, which protects the brain from pathogens, also prevents most drugs from gaining access to the brain functional tissue, a well-known challenge to the treatment of all brain diseases including neurodegenerative disorders like Parkinson's disease.
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Image: laboratory work; Copyright: panthermedia.net/Arne Trautmann

Diagnostics: biomarkers help tailor diuretic use in acute heart failure patients

31.05.2019

Adrenomedullin activity predicts which acute heart failure patients are at the greatest risk of death without diuretic treatment post-discharge, according to late breaking research presented today at Heart Failure 2019, a scientific congress of the European Society of Cardiology (ESC).
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Image: female researcher holds up a test strip; Copyright: Andrew Higley/UC Creative Services

Diagnostic test: simple test can tell if you're stressed out

29.05.2019

Stress is often called "the silent killer" because of its stealthy and mysterious effects on everything from heart disease to mental health. Now researchers at the University of Cincinnati have developed a new test that can easily and simply measure common stress hormones using sweat, blood, urine or saliva.
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Image: group of people posing for the camera; Copyright: UAB Institut de Neurociencies

Diagnostic test: biomarker can diagnose Alzheimer's in its earliest stages

27.05.2019

Alzheimer's disease is the major cause of dementia and so far, no effective treatment can prevent, delay or stop its progression. We know that AD has an extensive prodromal stage (with initial symptoms preceding the disease) which lasts 15 to 20 years before clinical signs are evident. To envision an effective treatment for AD, we need to be able to accurately diagnose AD at its earliest stages.
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Image: blood sample tubes; Copyright: panthermedia.net / scanrail

Blood test: How effective is stem cell transplantation?

24.05.2019

University of Maryland School of Medicine study shows the potential of transplanted stem cell secretions as a liquid biopsy.
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Image: Researcher with a microfluidic chip; Copyright: panthermedia.net / hquality

Microfluidic chip: New technology to capture tumor cells

20.05.2019

Instead of searching for a needle in a haystack, what if you were able to sweep the entire haystack to one side, leaving only the needle behind? That's the strategy researchers in the University of Georgia College of Engineering followed in developing a new microfluidic device that separates elusive circulating tumor cells (CTCs) from a sample of whole blood.
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Image: Physician is measuring blood pressure of a pregnant woman; Copyright: panthermedia.net/comzeal

Nanotechnology: magnetic beads to treat preeclampsia

16.05.2019

Preliminary laboratory tests show that functionalized magnetic beads successfully reduced blood levels of a harmful molecule that is elevated during preeclampsia, according to new research in the American Heart Association's journal Hypertension.
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Image: Bioprinted model of a vascular network in a glass tank; Copyright: Jordan Miller/Rice University

Organ bioprinting gets a breath of fresh air

15.05.2019

Bioengineers have cleared a major hurdle on the path to 3D printing replacement organs with a breakthrough technique for bioprinting tissues. The innovation allows scientists to create exquisitely entangled vascular networks that mimic the body's natural passageways for blood, air, lymph and other vital fluids.
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Image: close-up of liquid metal drop, used to make the mini-centrifuge; Copyright: RMIT University

Organ-on-a-chip: mini-centrifuge for simpler study of blood cells

10.05.2019

A simple innovation the size of a grain of sand means we can now analyse cells and tiny particles as if they were inside the human body. The new micro-device for fluid analysis will enable more tailored experiments in drug development and disease research via new 'organ-on-chip' systems.
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Image: man in the laboratory, in front of him a screen; Copyright: Joseph Xu, UM College of Engineering

Laboratory medicine: new method for liquid biopsies

07.05.2019

Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients' blood and urine. These "liquid biopsies" are less invasive than a traditional biopsy, and can provide information about what's happening throughout the body instead of just at a single site.
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Image: An ELISA test strip is compared to a coloured scale; Copyright: panthermedia.net/alexraths

Software aims to reduce variability in ELISA biomarker tests

24.04.2019

A new computational approach has been developed to reduce variability in common research biomarker tests, a promising step in improving the ability of biomedical researchers and basic scientists to reproduce data and facilitate more consistent results across laboratories and long-term projects.
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Super-resolved vascular imaging in vivo.  Credit: Pengfei Zhang, Lei Li, and Lihong V. Wang

Imaging: In vivo super-resolution PACT

19.04.2019

Photoacoustic computed tomography (PACT) is a non-invasive hybrid imaging technique that excites biological tissues with light and detects the subsequently generated ultrasound to form images.
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Image: man holds a wire that is one-fourth the size of a human hair; Copyright: John Eisele/ CSU Photography

Laboratory medicine: sensor to detect viral infections

09.04.2019

A team of Colorado State University researchers has developed technology that can detect extremely small amounts of antibodies in a person's blood. Antibodies develop to infect cells or kill pathogens, essentially fighting off a bacteria or virus. The levels of antibodies in the blood can tell whether that person is sick.
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Image: doctor with stetoscope examines child; Copyright: panthermedia.net / Wong Sze Fei

Imaging: Method to diagnose heart disease in children

04.04.2019

A new study by biomedical engineering researchers at the University of Arkansas could significantly improve methods for detecting and diagnosing congenital heart disease in infants and small children.
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Image: cells; Copyright: panthermedia.net / Lonely11

Machine learning model describes cell development

03.04.2019

From birth through to death, cells lead an eventful existence. Thanks to single-cell genomics, their destiny can be analyzed. But this method destroys the cell. In order to address this problem, researchers at the Helmholtz Zentrum München and the University of Massachusetts use pseudodynamics, a mathematical model that estimates developmental processes from single-cell time series observations.
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Image: a woman during a MRI; Copyright: panthermedia.net/SimplePhoto

Imaging: Contrast-enhanced MRI provides useful findings

02.04.2019

An essential part of breast intervention is the process of assessing concordance between imaging findings and core biopsy results. When pathology results are considered benign discordant, current standard of care is surgical excision, even though many of these lesions will ultimately be found benign.
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Image: the new wearable device; Copyright: Tae Hyun Kim

Biopsy alternative: 'Wearable' captures cancer cells from blood

02.04.2019

A prototype wearable device, tested in animal models, can continuously collect live cancer cells directly from a patient's blood. The device developed by a team of engineers and doctors at the University of Michigan could help doctors diagnose and treat cancer more effectively.
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Image: Construction of an organelle in a living cell for protein biosynthesis; Copyright: Gemma Estrada Girona

Laboratory technology: designer organelles in cells

01.04.2019

A research team led by biophysical chemist Professor Edward Lemke has engineered a designer organelle in a living mammalian cell in a new complex biological translation process. The created membraneless organelle can build proteins from natural and synthetic amino acids carrying new functionalities.
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Image: CT scan open; Copyright: panthermedia.net/SimpleFoto

Functional imaging: a look at the command center

01.04.2019

All information from our body and the environment converges in our brain and is transformed into reactions in milliseconds. It is essential for medicine and research to know what our switching centre looks like. Functional methods are used to observe it more closely during work.
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Image: Patient during an fMRI examination; Copyright: panthermedia.net/Chris De Silver

Functional imaging: what makes the brain tick?

01.04.2019

Our brain is the command center of our body. This is where all information and impressions are collected and converted into responses and movements. Modern imaging techniques offer physicians and researchers unique insights into the actions of the human central nervous system. The functional imaging technique allows them to watch our brain in action.
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Image: Ellipsoid of revolution with a gold coating to detect backscattered photons from the skin tissue; Copyright: Sven Delbeck/Fachhochschule Südwestfalen

Blood Sugar Monitoring: Using Infrared Instead of Invasive Techniques

22.03.2019

Over six million people in Germany have diabetes. It is estimated that almost 400 million people are affected by this disease worldwide. Diabetes sufferers must prick their fingers several times a day to monitor their blood sugar.
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From algorithm to rapid test – Artificial Intelligence classifies blood cells

21.11.2018

Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
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Diagnostics at record speeds – POCT in high-performance sports

02.11.2018

This is what diagnostic investigation normally looks like: a patient sample is collected, sent to the laboratory and analyzed. Once that's completed, the patient is told of the lab test result. But if the patient is a high-performance athlete and has to follow and stick to a rigid training schedule, he or she needs these results immediately. What makes this possible? Point-of-care testing!
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Image: AcCellerator research device at an exhibition stand; Copyright: Daniel Klaue, ZELLMECHANIK DRESDEN GmbH

Cells in the speed trap – diagnosis in a matter of seconds

22.06.2018

A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
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Image: Woman holding a doll in a glowing pyjamas; Copyright: Empa

Illuminated pyjamas treat jaundice in mommy's arms

20.12.2017

Sixty percent of newborns are affected by jaundice during their first days of life. In most cases, the condition is harmless. The ailment is more pronounced in premature babies, whose treatment involves irradiation with blue light in a special incubator – naked and alone.
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Image: POCT-device and patient files; Copyright: panthermedia.net/gabriella

Point-of-care testing: helpful when things need to happen quickly?

01.08.2017

Advances in technology and analysis techniques, as well as the increasing miniaturization of laboratory equipment and processes, make it possible: patient-side laboratory testing, better known as point-of-care testing or POCT. There are many POCT projects and all of them promise a rapid diagnosis as well as economic advantages. But are these tests also suited for everyday medical testing?
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Image: blood is taken from a finger and analysed by a blood testing device; Copyright:hes_so_valais_wallis

Without any delay: drug dose adjustment at the point of care

01.08.2017

Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
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Image: Collage made of two images, one show a round, transparent plastic disc with micro channels, one shows a plastic chip; Copyright: Hahn-Schickard, Image Bernd Müller

Prenatal diagnosis: genetic analysis using droplet PCR

24.07.2017

A new analysis method that uses fetal DNA extracted from the mother’s blood is designed to non-invasively reach a prenatal diagnosis of genetic disorders in a child. A task force of the Hahn Schickard Society for Applied Research is an active part of the "ANGELab" project and co-developed this diagnostic procedure.
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