Organ-on-a-chip - the mini organs of the future? -- MEDICA - World Forum for Medicine

Image: A man with a smartwatch on his wrist; Copyright: PantherMedia/Wavebreakmedia Ltd

Controlling insulin production with a smartwatch

15/06/2021

Many modern fitness trackers and smartwatches feature integrated LEDs. The green light emitted, whether continuous or pulsed, penetrates the skin and can be used to measure the wearer's heart rate during physical activity or while at rest.
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Image: A woman is putting her arms through holes into a plastic tent; Copyright: NASA

Better ways to culture living heart cells on the ISS

10/06/2021

As part of preparing for an experiment aboard the International Space Station, researchers explored new ways to culture living heart cells for microgravity research.
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Image: Man holding samples in a laboratory; Copyright: UPV

Biosensor developed to aid early diagnosis of breast cancer

24/05/2021

A team of Spanish researchers have developed, at the laboratory level, a prototype of a new biosensor to help detect breast cancer in its earliest stages.
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Image: Red dots and shapes and a chemical formula on black ground; Copyright: Yoshikatsu Sato

Unprecedentedly versatile new DNA staining probe

20/05/2021

A group of scientists at Nagoya University, Japan, have developed an incredibly versatile DNA fluorescent dye, named 'Kakshine' after a former NU student of its members, Dr. Kakishi Uno, but it also means to make the nucleus shine brightly, since the nucleus is pronounced 'Kaku' in Japanese.
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Microfluidics: efficiently smuggling drugs into cells

19/05/2021

A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells. In this way, researchers can test new therapies more easily than before.
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Image: A female researcher in a laboratory, holding a pipette - Prof. Illana Gozes; Copyright: Tel Aviv University

Orthopedic implants: effective inflammation prevention

18/05/2021

Dental and orthopedic implants are widely used around the world. Common causes for implant failure are the immune response against oral bacteria and titanium particles shed by the implant.
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Image: A male and a female researcher standing in a laboratory - Prof. Raz Jelinek and student Ravit Malishev; Copyright: Dani Machlis/BGU

Molecular tweezers attack antibiotic resistant bacteria

17/05/2021

Researchers from Ben-Gurion University (BGU), together with American and German colleagues, have developed new "molecular tweezers" to combat antibiotic-resistant bacteria. Their recently announced findings were published in Cell Chemical Biology.
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Image: a hand pulls a novel, transparent material from a wound on a forearm; Copyright: Anna-Lena Lundqvist/Chalmers

New material can protect against resistant bacteria

13/05/2021

Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers great hope for combating a growing global problem.
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Image: Drawing showing how a brain tumor surgery site is outfitted with pieces of mesh; Copyright: D. Beghetto/IIT

Microscopic polymeric network to attack glioblastoma multiforme

30/04/2021

Researchers at Istituto Italiano di Tecnologia in collaboration with Stanford Medicine and the San Raffaele Hospital have demonstrated with preclinical studies the effectiveness of a new biomedical implant for the treatment of glioblastoma multiforme.
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Image: Artist's rendering of a square tissue implant attached to bones in the shoulder; Copyright: Sparta Biopharma

Shoulder injury could heal faster with tissue implant

07/04/2021

Longer-lasting rotator cuff repair may be possible with BioEnthesis, a Purdue University invention available on the market.
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Image: A spoon with a small amount of hydrogel; Copyright: UPV

Hydrogel cuts in half recovery time from muscle injuries

05/04/2021

A team from the Universitat Politècnica de València (UPV) and the CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has designed and tested, at a preclinical level, a new biomaterial for the treatment and recovery of muscle injuries.
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Image: biosensor on a shirt; Copyright: Paulo A. Raymundo-Pereira, IFSC-USP

Biosensors help with non-invasive diagnosis of diseases

24/03/2021

Brazilian researchers tested the capacity of different materials to produce sensors for the detection of PCA3, a gene that is overexpressed in prostate cancer. The technique can also be used to diagnose infectious diseases, including COVID-19.
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Image: stamp for cells; Copyright: UPF / Nature Communications

Biological device capable of computing by printing cells on paper

22/03/2021

The Research Group on Synthetic Biology for Biomedical Applications at Pompeu Fabra University in Barcelona, Spain, has designed a cellular device capable of computing by printing cells on paper. For the first time, they have developed a living device that could be used outside the laboratory without a specialist, and it could be produced on an industrial scale at low cost.
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Image: Artist’s rendering of small robots with grapplers and searchlights that swim between red blood cells; Copyright: PantherMedia/Andreus

Autonomous medical technology: independently in the body

01/02/2021

Therapies need to be carried out with high reliability by trained personal. This will not change in the future. But maybe we will be able to let systems in the patient’s body do some of the work. Some approaches are already aiming to make implants more independent so they will be able to flexibly react to changes. Read more in our Topic of the Month!
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Image: Artist’s rendering of small star-shaped machines between red blood cells; Copyright: PantherMedia/Michael Osterrieder

Autonomous medical devices: running well in your body

01/02/2021

In theory, autonomous medical technologies can be used in a diagnostic or therapeutic capacity inside the body under certain conditions. This may not sound like a new invention at first. After all, implantable cardioverter-defibrillators have monitored and fixed abnormal heart rhythm for many years.
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Image: cell matrix; Copyright: TU Wien

Multi-photon lithography: printing cells with micrometer accuracy

01/12/2020

How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
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Bioprinting: life from the printer

01/12/2020

It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
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Image: three vials, one with hydrogels, one with bio ink and one with unmodified gelatine; Copyright: Fraunhofer IGB

"Cells are highly sensitive" – material development for bioprinting

01/12/2020

The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
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Image: A miniaturized, round sensor under a fingertip; Copyright: TU Dresden

SmartLab: all-in-one automation, digitalization, and miniaturization

01/09/2020

Laboratories have to analyze and interpret an ever-increasing number of samples for research and diagnostic services, generating lots of data in the process. At the same time, labs are required to produce quality results and operate with speed. Processes that could once be managed using laboratory notebooks and isolated systems must become smart in the future to improve lab efficiency.
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Israeli medical devices showcase digital innovations at MEDICA

24/08/2020

For the annual MEDICA trade fair, companies from all over the world assemble in Düsseldorf. The Israel Export Institute has been a part of it for the last couple of years. They present medical devices and digital innovations from different Israeli companies at their joint booth.
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Image: Computer-generated image of an arborizing blood vessel; Copyright: panthermedia.net/Ugreen

Angiogenesis: light shows blood vessels the way

03/02/2020

Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
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Image: Two knees of a woman next to each other, the left knee has a surgical suture; Copyright: panthermedia.net/wujekspeed

Regenerative medicine: creating a new body?

03/02/2020

Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
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Image: A half-transparent red piece of tissue in a glass filled with a yellow fluid; Copyright: United Therapeutics

rhCollagen: genetically engineered building block for regenerative medicine

03/02/2020

Collagen is the stuff that holds our bodies together and that houses our cells. In regenerative medicine, it is also the stuff that can be applied to wounds to support healing. However, collagen from animal or human sources has some drawbacks for today’s medicine. This is where rhCollagen from the Israeli company CollPlant comes into play.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01/02/2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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Early detection: Tattoo signals cancer – and more

09/07/2018

People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
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Image: Two hands are holding a tubular frame that is carrying a glistening wet, white tube; Copyright: Leibniz University of Hanover/Institute of Technical Chemistry

Tissue engineering: how to grow a bypass

23/04/2018

A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
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