React early, breathe free – comprehensive COPD management -- MEDICA - World Forum for Medicine

Image: Chest CT data interpreted by AI; Copyright: American Roentgen Ray Society

American Roentgen Ray Society

AI saves one hour of daily chest CT interpretation time in study

17/06/2022

Cardiothoracic radiologists exhibited a 22.1% reduction in chest CT interpretations times when having access to results from an automated AI support platform during real-world clinical practice.
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Bild: A man in glasses and a jacket, Ludovic Vallier, poses for the camera ; Copyright: BIH/David Ausserhofer

BIH/David Ausserhofer

Ludovic Vallier grows liver tissue from stem cells

16/06/2022

Effective July 1, 2022, Ludovic Vallier will take up the W3 Einstein Strategic Professorship for Stem Cells in Regenerative Therapies at the Berlin Institute of Health at Charité (BIH).
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Image: A smiling man is sitting behind a laboratory device; Copyright: Universität Bielefeld/M.-D. Müller

Universität Bielefeld/M.-D. Müller

Making drug interactions in the liver visible

15/06/2022

Bielefeld University is coordinating a new EU-research project that seeks to produce microscopic liver tissue cultures that can survive for 14 days, while also using imaging methods to investigate how liver cells react to combinations of different medications.
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Image: Man in a suit and glasses poses for the camera; Copyright: Klaus Nagels

Klaus Nagels

Precise blood diagnostics improve treatment outcome for lung cancer

10/06/2022

Non-small cell lung carcinoma is a particularly aggressive type of lung cancer. Tumor cells and tumor DNA (ctDNA) in the blood of patients with the disease can be analyzed by means of liquid biopsy throughout the course of the disease.
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Image: Three physicians in OR clothing work with a medical device; Copyright: USZ

USZ

Human liver treated in a machine and transplanted for the first time

07/06/2022

The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside a body and then implanted the recovered organ into a cancer patient. One year later, the patient is doing well.
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Image: smiling man in a suit in front of a MRI machine - Prof Andrew Jabbour; Copyright: Victor Chang Cardiac Research Institute

Victor Chang Cardiac Research Institute

Virtual biopsy set to transform heart transplant care

02/06/2022

The days of heart transplant survivors undergoing invasive biopsies could soon be over after a new MRI technique has proven to be safe and effective; reducing complications and hospital admissions.
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Image: A proctologist holds an endoscope in his hand; Copyright: romankosolapov

romankosolapov

Computer-assisted colonoscopy identifies more precancerous polyps

30/05/2022

Colonoscopies performed with computer-aided detection, or artificial intelligence, (AI) saw an increase in the overall rate of detection of adenoma, or cancerous and precancerous polyps, by 27 percent in average-risk patients.
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A diagram intended to illustrate genetic manipulation of the female reproductive tract ; Copyright: AG Chumduri

AG Chumduri

Cervix: Research progress thanks to mini organs

23/05/2022

Life-like organ replicas - so-called 3D organoids - are a good way to research disease processes. A team from the University of Würzburg has now presented a kind of blueprint for such a model of the cervix.
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Image: Assembly of biochips with attached tubes; Copyright: Fraunhofer ILT, Aachen

Fraunhofer ILT, Aachen

Process chains for isolation and analysis: from single cells to organoids

17/05/2022

Researchers at the Fraunhofer Institute for Laser Technology ILT are working on new tools for the preparation and analysis of single cells and cell assemblies. The team developed the "Liftoscope", a system for cell sorting for subsequent cultivation that can analyze and transfer biomaterials precisely and in a way that is gentle on cells.
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Image: The new multi-organ chip is shown; Copyright: Kacey Ronaldson-Bouchard/Columbia Engineering

Kacey Ronaldson-Bouchard/Columbia Engineering

Plug-and-play organ-on-a-chip can be customized to the patient

05/05/2022

Major advance from Columbia Engineering team demonstrates first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer
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Image: Woman holding her stomach painfully ; Copyright: Prostock-studio

Prostock-studio

Nanoparticles show promise for locating, removing endometriosis lesions

25/04/2022

Scientists have developed a new nanotechnology approach for locating and removing the painful and dangerous lesions associated with endometriosis, a common gynecological condition in women of childbearing age.
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Image: Microscope image: damage to lung tissue caused by the invasive fungal infection aspergillosis.; Copyright: Zoltán Cseresnyés/Leibniz-HKI

Zoltán Cseresnyés/Leibniz-HKI

How do fungal infections spread in the human lung?

22/04/2022

A chip model allows us to observe growth in the tissue.
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Image: Scientist fills microplates ; Copyright: microgen

microgen

Want to 3D print a kidney? Start by thinking small

21/04/2022

Stevens computational model aims to accelerate microfluidic bio-printing that opens up a pathway for 3D printing any kind of organ at any time.
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Image: A person in a white t-shirt is holding an anatomical model of the kidney in front of their abdomen; Copyright: PantherMedia/benschonewille

PantherMedia/benschonewille

Technology against organ shortage – Support for the successful transplant

03/02/2022

The waiting time for a donor organ is long nowadays since the need for organs vastly exceeds their availability. But we have possibilities to improve the situation and help as many people as possible to survive despite organ failure: Some organ functions can already be substituted by technology. But medicine is also researching ways to make more organs available for transplant.
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Image: A normothermic perfusion machine; Copyright: Charité – Universitätsmedizin Berlin

Charité – Universitätsmedizin Berlin

Machine Perfusion: Increasing the Safety of Marginal Organ Transplants

03/01/2022

The shortage of donor organs is a major global issue. An aging population, a reluctance towards organ donation, and logistical challenges related to organ shipping play an important role in this setting. Machine perfusion can be a way to expand and preserve the donor pool for eligible transplant recipients.
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Image: Man with a bare upper-body is showing an implanted cardiac support system; Copyright: PantherMedia/NikD51

PantherMedia/NikD51

Donor organs: Solving the shortage with technology

03/01/2022

Patients waiting for a donor organ must have a lot of patience and a bit of luck. Aging and a rise in chronic disease prevalence means the need for donor organs is much greater than the number that is available. To help those who need organ transplants, scientists must create new technologies.
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Image: cell matrix; Copyright: TU Wien

Multi-photon lithography: printing cells with micrometer accuracy

01/12/2020

How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
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Image: Illustrations of various 3D-printed prostheses, implants and organs; Copyright: PantherMedia/annyart

Printed life – possibilities and limits of bioprinting

01/12/2020

Implants, prostheses and various other components made of plastic, metal or ceramics are already being produced by additive manufacturing. But skin, blood vessels or entire organs from the printer – is that possible? For years now, intensive research has been underway into the production of biologically functional tissue using printing processes. Some things are already possible with bioprinting.
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Image: 3D printer with a human heart inside, next to a box with

Bioprinting: life from the printer

01/12/2020

It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
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Image: three vials, one with hydrogels, one with bio ink and one with unmodified gelatine; Copyright: Fraunhofer IGB

"Cells are highly sensitive" – material development for bioprinting

01/12/2020

The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
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Image: Two knees of a woman next to each other, the left knee has a surgical suture; Copyright: panthermedia.net/wujekspeed

Regenerative medicine: creating a new body?

03/02/2020

Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
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Image: Computer-generated image of an arborizing blood vessel; Copyright: panthermedia.net/Ugreen

Angiogenesis: light shows blood vessels the way

03/02/2020

Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
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Image: The shoulder of a man with a surgical suture; Copyright: panthermedia.net/JPCPROD

Regenerative medicine: helps the body healing

03/02/2020

Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
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Image: Endoscope capsule (left) next to an endoscope tube (right); Copyright: panthermedia.net/phonlamai

panthermedia.net/phonlamai

A new type of endoscopy – small, easy, comfortable

22/01/2020

Patients have to undergo a gastroscopy to rule out gastrointestinal conditions. Many dread this procedure since a thin, flexible tube is being pushed through the esophagus and stomach. Ovesco Endoscopy AG has teamed up with other project partners in the nuEndo research project to develop a capsule endoscopy device that is tiny, easy to swallow and makes the test more comfortable for the patient.
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Image: patient with pain in fingers; Copyright: panthermedia.net/Milkos

APRICOT-project: implant "help(s) patients heal themselves"

01/01/2020

Today, people tend to live longer, while an increasing number of patients suffer from osteoarthritis. Even younger generations are now at a higher risk of getting osteoarthritis due to the frequent use of mobile devices. The EU research project APRICOT aims to develop a novel type of implant for the treatment of osteoarthritis of the hands – helping patients heal themselves.
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Image: doctor consoles patients before surgery; Copyright: panthermedia.net/luckybusiness

Endoprosthetic surgery: modern and traditional approaches

01/01/2020

Surgery is required if you need an artificial joint. Patients and doctors must select the type of surgery that’s best suited and choose between robot-assisted, traditional or minimally invasive surgical approaches. Post-operative risks should be kept to a minimum, while benefits should outweigh any possible complications.
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Image: Blood sample labelled

panthermedia.net/olanstock

Cardiac diagnostics – prompt and personalized

08/11/2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Lung monitoring of a patient with PulmoVista 500 by Draeger; Copyright: Drägerwerk AG & Co. KGaA

Restoring Pulmonary Function

01/03/2019

People suffering from lung disease temporarily need ventilator support because they are unable to breathe naturally. Mechanical ventilation is designed to ensure the survival of these patients. The goal is to adapt the ventilator settings and tailor them the patient's specific needs and prevent lung tissue damage.
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Image: Preemie doll with drug delivery system on the nose; Copyright: Fraunhofer ITEM/Till Holland

Fraunhofer ITEM/Till Holland

Gentle medication for the little ones – with every breath

22/02/2019

According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Woman at her desk holding her back; Copyright: panthermedia.net/Andrey Popov

panthermedia.net/Andrey Popov

AI ensures dynamic sitting

22/01/2019

Whether in the office, at school or behind the wheel: we spend a lot of time sitting and often stay in the same position for too long. The possible side effects are stiffness, back problems and pain. The SensA-Chair smart seating solution combats decreased mobility and ensures dynamic sitting.
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Image: View over the shoulders of two doctors at a screen showing a model of a heart; Copyright: panthermedia.net/Wavebreakmedia ltd

panthermedia.net/Wavebreakmedia ltd

Regenerative heart valves: from simulation to replacement

23/07/2018

Every year, more than 250,000 patients worldwide receive heart valve implants. Children require repeated replacement surgery because their bodies are still growing, the prosthetic heart valves are not. Regenerative heart valves solve this problem. Until now, we have only been able to monitor how these living implants develop in the body after the fact. Computer models now make this predictable.
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Image: two men in the laboratory next to the Organ Care System with a pig's lung inside; Copyright: Kaiser/MHH

Kaiser/MHH

Organ Care System: treatment under extreme conditions

08/05/2018

Multidrug-resistant organisms that are treated with a dosage that exceeds the regular dose a hundred times and at temperatures of over 40 degrees Celsius – the human organism is unable to handle it. Yet if the diseased organ is treated outside of the body, extreme conditions are an option. For the first time, physicians have succeeded in treating a severe case of pneumonia by using the OCS.
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Image: Photograph of hands with hyperspectral imaging; Copyright: Diaspective Vision GmbH

Diaspective Vision GmbH

Precision surgery thanks to informative hyperspectral imaging

08/02/2018

When body tissue is reconnected during a tumor operation in the gastrointestinal tract, surgeons need information about the current state of these so-called anastomoses. The new, non-invasive hyperspectral imaging technology now makes it possible to measure the crucial parameters during surgery and thereby increase surgical precision.
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