24.06.2019A team of researchers from Jena is presenting a groundbreaking new method for the rapid, gentle and reliable detection of tumors with laser light. For the first time, the Leibniz IPHT will present a compact device for rapid cancer diagnosis during surgery. The optical method will help surgeons to remove tumors more precisely and could make cancer operations possible without a scalpel.
19.06.2019Sickle cell disease is a hereditary disorder that affects red blood cells, distorting their natural disc shape into a crescent moon or "sickle" shape. Normal red blood cells move freely through small vessels throughout the body to deliver oxygen. With sickle cell disease, the misshapen red blood cells become hard and sticky, making it difficult for them to move through blood vessels.
18.06.2019Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
17.06.2019Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
14.06.2019A UCLA-led research team has developed a faster and more accurate way to determine where the many bacteria that live in, and on, humans come from. Broadly, the tool can deduce the origins of any microbiome, a localized and diverse community of microscopic organisms.
14.06.2019has developed a new "virtual biopsy" device that can quickly determine a skin lesion's depth and potential malignancy without using a scalpel.
13.06.2019When it comes to the diagnosis of pigmented skin lesions, artificial intelligence is superior to humans. In a study conducted under the supervision of the MedUni Vienna human experts "competed" against computer algorithms. The algorithms achieved clearly better results, yet their current abilities cannot replace humans.
10.06.2019Combining tissue imaging and artificial intelligence, Hollings Cancer Center researchers at the Medical University of South Carolina probed deeper into how cell division cycles are regulated, in this study released online in the May 2019 issue of Cell Reports.
07.06.2019Researchers from The Westmead Institute for Medical Research have developed a standardized method of measuring the immune response in islet transplant recipients, helping predict patient outcomes.
04.06.2019Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.
29.05.2019Stress is often called "the silent killer" because of its stealthy and mysterious effects on everything from heart disease to mental health. Now researchers at the University of Cincinnati have developed a new test that can easily and simply measure common stress hormones using sweat, blood, urine or saliva.
28.05.2019The production of artificial organs is a hot research topic. In the near future, artificial organs will compensate for the lack of organ donations and replace animal experiments. Although there are already promising experiments with 3D printers that use a "bio-ink" containing living cells, a functional organ has never been created in this way.
24.05.2019University of Maryland School of Medicine study shows the potential of transplanted stem cell secretions as a liquid biopsy.
24.05.2019Prostate cancer is the second-leading cause of male cancer deaths worldwide. Deaths from prostate cancer are primarily due to metastasized cancer, in which cancer cells have migrated through the body and begun to grow in other areas. Results reported in Biomicrofluidics, from AIP Publishing, promise a new way to detect this deadly disease through a simple, inexpensive device.
23.05.2019UNIGE researchers have developed a cell co-culture platform that can reproduce a patient's tumour in 3D and test the best treatment combinations for its specific case in just five days.
20.05.2019Instead of searching for a needle in a haystack, what if you were able to sweep the entire haystack to one side, leaving only the needle behind? That's the strategy researchers in the University of Georgia College of Engineering followed in developing a new microfluidic device that separates elusive circulating tumor cells (CTCs) from a sample of whole blood.
15.05.2019New active substances that are suitable for drugs are initially tested in animal experiments. However, the results cannot always be transferred to the human organism. At the Karlsruhe Institute of Technology, Prof. Ute Schepers from vasQlab explains how active substances can be tested in human tissue without endangering human health.
14.05.2019Data-sampling method makes "sketches" of unwieldy biological datasets while still capturing the full diversity of cell types. MIT researchers are now bringing that concept to computational biology, with a novel method that extracts comprehensive samples of massive cell datasets that are easier to analyze for biological and medical studies.
13.05.2019A novel imaging technique that uses a synthesized form of scorpion venom to light up brain tumors has shown promise in a clinical trial. The imaging system enables neurosurgeons to better see malignant growths that often are difficult to fully eliminate.
10.05.2019A simple innovation the size of a grain of sand means we can now analyse cells and tiny particles as if they were inside the human body. The new micro-device for fluid analysis will enable more tailored experiments in drug development and disease research via new 'organ-on-chip' systems.
07.05.2019Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients' blood and urine. These "liquid biopsies" are less invasive than a traditional biopsy, and can provide information about what's happening throughout the body instead of just at a single site.
02.05.2019While network algorithms are usually associated with finding friends on social media, researchers at the University of Sussex have shown how they could also be used improve the effectiveness of cancer treatment, by predicting the interactions between genes.
01.05.2019Ovarian cancer is usually diagnosed only after it has reached an advanced stage, with many tumors spread throughout the abdomen. Most patients undergo surgery to remove as many of these tumors as possible, but because some are so small and widespread, it is difficult to eradicate all of them.
30.04.2019A breast cancer test has been found that helps doctors make treatment decisions for some breast cancer patients, following research carried out at Queen Mary University of London and funded by Cancer Research UK.
26.04.2019Columbia engineers develop a new platform that recreates cancer in a dish to quickly determine the best bacterial therapy.
16.04.2019Biomedical engineers at Duke University have developed an automated process that can trace the shapes of active neurons as accurately as human researchers can, but in a fraction of the time.
16.04.2019Experimental molecular assays with single-cell resolution generate big and complex data. Researchers at Helmholtz Zentrum München and the Technical University of Munich are now presenting their computer algorithm PAGA.
15.04.2019A new technique for the decontamination of organs before transplantation using ultraviolet and red light irradiation has been developed by Brazilian and Canadian researchers and is described in an article published in the journal Nature Communications.
12.04.2019North Carolina State University researchers have developed a technique to improve the characteristics of engineered tissues by using ultrasound to align living cells during the biofabrication process.
05.04.2019Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.
03.04.2019From birth through to death, cells lead an eventful existence. Thanks to single-cell genomics, their destiny can be analyzed. But this method destroys the cell. In order to address this problem, researchers at the Helmholtz Zentrum München and the University of Massachusetts use pseudodynamics, a mathematical model that estimates developmental processes from single-cell time series observations.
02.04.2019A prototype wearable device, tested in animal models, can continuously collect live cancer cells directly from a patient's blood. The device developed by a team of engineers and doctors at the University of Michigan could help doctors diagnose and treat cancer more effectively.
01.04.2019A research team led by biophysical chemist Professor Edward Lemke has engineered a designer organelle in a living mammalian cell in a new complex biological translation process. The created membraneless organelle can build proteins from natural and synthetic amino acids carrying new functionalities.
01.02.2019In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
01.02.2019The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
01.02.2019Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
21.11.2018Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
09.07.2018People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
22.06.2018A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
23.04.2018A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
01.03.2018Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
22.02.2018Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
08.01.2018Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
22.08.2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
01.08.2017Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
14.07.2017A microscope that is only a few millimeters in size and that can help to consider cell changes in real time. This is the goal of the EU project ChipScope. Scientists led by Dr. Hutomo Wasisto in Braunschweig help to make this project come true.
03.07.2017Precision work is absolutely essential in eye surgery since the surgical site is very minute and sensitive. This is why eye surgeons have been using lasers for years. Femtosecond lasers are especially well suited to serve this purpose because they are able to cut tissue with great precision and little energy, which prevents unwanted side effects of surgery.