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Image: blood-brain barrier dysfunction under hypoxia; Copyright: WFIRM

Organoids: inflammation induced blood-brain barrier dysfunction

30/07/2020

The scientists who developed the first 3D multicellular brain organoid with a functional blood brain barrier now report that the model could be a promising platform to screen drugs that could work to control inflammation, which is at the center of many neurological conditions, like ischemic stroke.
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Image: symbol image for artificial intelligence; Copyright: MIPT Press Office

Machine learning helps grow artificial organs

08/07/2020

Researchers have developed a neural network capable of recognizing retinal tissues during the process of their differentiation in a dish. Unlike humans, the algorithm achieves this without the need to modify cells, making the method suitable for growing retinal tissue for developing cell replacement therapies to treat blindness and conducting research into new drugs.
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Graphic: Low-oxygen cell culture conditions combined with human heart organoids recreate tissue-level features of a post-heart attack heart; Copyright: Dr. Dylan Richards

Tissue Engineering: heart attack in a dish

16/06/2020

A team of investigators at the Medical University of South Carolina (MUSC) and Clemson University recently reported in an article in Nature Biomedical Engineering that they have developed human cardiac organoids less than 1 millimeter in diameter that closely resemble the physiological conditions that occur during a heart attack.
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Image: 7 weeks old human embryo surrounded by placenta; Copyright: Hill, M.A. (2020, May 18)

Unique insight into development of human brain

28/05/2020

Stem cell researchers at Lund University in Sweden have developed a new research model of the early embryonic brain. The aim of the model is to study the very earliest stages of brain to understand how different regions in the brain are formed during embryonic development.
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Image: detailed image of the bladder device with a sensor and an actuator; Copyright: National University of Singapore

Novel device to improve performance of underactive bladders

06/05/2020

Individuals with an underactive bladder, for example following a spinal cord injury, often cannot sense bladder fullness or are unable to empty the bladder completely. This distressing symptom can seriously affect one's quality of life. It may also lead to medical complications such as urinary tract infection, as well as physical discomfort and potential for personal embarrassment.
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Image: Two knees of a woman next to each other, the left knee has a surgical suture; Copyright: panthermedia.net/wujekspeed

Regenerative medicine: creating a new body?

03/02/2020

Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
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Image: Computer-generated image of an arborizing blood vessel; Copyright: panthermedia.net/Ugreen

Angiogenesis: light shows blood vessels the way

03/02/2020

Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
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Image: The shoulder of a man with a surgical suture; Copyright: panthermedia.net/JPCPROD

Regenerative medicine: helps the body healing

03/02/2020

Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
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Image: Endoscope capsule (left) next to an endoscope tube (right); Copyright: panthermedia.net/phonlamai

A new type of endoscopy – small, easy, comfortable

22/01/2020

Patients have to undergo a gastroscopy to rule out gastrointestinal conditions. Many dread this procedure since a thin, flexible tube is being pushed through the esophagus and stomach. Ovesco Endoscopy AG has teamed up with other project partners in the nuEndo research project to develop a capsule endoscopy device that is tiny, easy to swallow and makes the test more comfortable for the patient.
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Image: patient with pain in fingers; Copyright: panthermedia.net/Milkos

APRICOT-project: implant "help(s) patients heal themselves"

01/01/2020

Today, people tend to live longer, while an increasing number of patients suffer from osteoarthritis. Even younger generations are now at a higher risk of getting osteoarthritis due to the frequent use of mobile devices. The EU research project APRICOT aims to develop a novel type of implant for the treatment of osteoarthritis of the hands – helping patients heal themselves.
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Image: doctor consoles patients before surgery; Copyright: panthermedia.net/luckybusiness

Endoprosthetic surgery: modern and traditional approaches

01/01/2020

Surgery is required if you need an artificial joint. Patients and doctors must select the type of surgery that’s best suited and choose between robot-assisted, traditional or minimally invasive surgical approaches. Post-operative risks should be kept to a minimum, while benefits should outweigh any possible complications.
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Image: Blood sample labelled

Cardiac diagnostics – prompt and personalized

08/11/2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Lung monitoring of a patient with PulmoVista 500 by Draeger; Copyright: Drägerwerk AG & Co. KGaA

Restoring Pulmonary Function

01/03/2019

People suffering from lung disease temporarily need ventilator support because they are unable to breathe naturally. Mechanical ventilation is designed to ensure the survival of these patients. The goal is to adapt the ventilator settings and tailor them the patient's specific needs and prevent lung tissue damage.
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Image: Preemie doll with drug delivery system on the nose; Copyright: Fraunhofer ITEM/Till Holland

Gentle medication for the little ones – with every breath

22/02/2019

According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Woman at her desk holding her back; Copyright: panthermedia.net/Andrey Popov

AI ensures dynamic sitting

22/01/2019

Whether in the office, at school or behind the wheel: we spend a lot of time sitting and often stay in the same position for too long. The possible side effects are stiffness, back problems and pain. The SensA-Chair smart seating solution combats decreased mobility and ensures dynamic sitting.
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Image:Lung; Copyright: panthermedia.net/CLIPAREA

Lung Imaging – Keeping the Respiratory System Healthy

05/10/2018

Many people have damaged or suboptimally functioning lungs. An accurate diagnosis and subsequent treatment are vital to protect this life-sustaining organ. Modern imaging solutions help physicians and patients understand what happens inside the lungs.
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Image: View over the shoulders of two doctors at a screen showing a model of a heart; Copyright: panthermedia.net/Wavebreakmedia ltd

Regenerative heart valves: from simulation to replacement

23/07/2018

Every year, more than 250,000 patients worldwide receive heart valve implants. Children require repeated replacement surgery because their bodies are still growing, the prosthetic heart valves are not. Regenerative heart valves solve this problem. Until now, we have only been able to monitor how these living implants develop in the body after the fact. Computer models now make this predictable.
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Image: two men in the laboratory next to the Organ Care System with a pig's lung inside; Copyright: Kaiser/MHH

Organ Care System: treatment under extreme conditions

08/05/2018

Multidrug-resistant organisms that are treated with a dosage that exceeds the regular dose a hundred times and at temperatures of over 40 degrees Celsius – the human organism is unable to handle it. Yet if the diseased organ is treated outside of the body, extreme conditions are an option. For the first time, physicians have succeeded in treating a severe case of pneumonia by using the OCS.
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Image: Photograph of hands with hyperspectral imaging; Copyright: Diaspective Vision GmbH

Precision surgery thanks to informative hyperspectral imaging

08/02/2018

When body tissue is reconnected during a tumor operation in the gastrointestinal tract, surgeons need information about the current state of these so-called anastomoses. The new, non-invasive hyperspectral imaging technology now makes it possible to measure the crucial parameters during surgery and thereby increase surgical precision.
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