18/08/2021A team in the Department of Biomedical Engineering, co-led by associate professor Dr. Akhilesh Gaharwar and assistant professor Dr. Abhishek Jain, has designed a 3D-bioprinted model of a blood vessel that mimics its state of health and disease, thus paving the way for possible cardiovascular drug advancements with better precision.
22/07/2021Efforts to understand cardiac disease progression and develop therapeutic tissues that can repair the human heart are just a few areas of focus for the Feinberg research group. The group's latest dynamic model, mimics physiologic loads on engineering heart muscle tissues, yielding an unprecedented view of how genetics and mechanical forces contribute to heart muscle function.
06/07/2021A research has demonstrated the viability of 3D-printed tissue scaffolds that harmlessly degrade while promoting tissue regeneration following implantation. The scaffolds showed highly promising tissue-healing performance, including the ability to support cell migration, the 'ingrowth' of tissues, and revascularisation (blood vessel growth).
01/12/2020How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
01/12/2020The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
01/12/2020It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
23/09/2019For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
23/07/2018Every year, more than 250,000 patients worldwide receive heart valve implants. Children require repeated replacement surgery because their bodies are still growing, the prosthetic heart valves are not. Regenerative heart valves solve this problem. Until now, we have only been able to monitor how these living implants develop in the body after the fact. Computer models now make this predictable.
23/04/2018A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
08/01/2018Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.