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Image: imCMS model; Copyright: University of Zurich

AI: molecular tumor classification and prognosis in patients with colorectal cancer

09.07.2019

Treating physicians need information about the molecular subtype of the tumor if they are to provide targeted therapy for colorectal carcinoma. A research team from University Hospital Zurich and the University of Oxford have now developed a method to predict the molecular classification of colorectal cancer from digital pathology slides.
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Image: elderly man in the lab injecting a liquid into a chip; Copyright: panthermedia.net/matej kastelic

Human-on-a-chip: prediction of in vivo results based on in vitro model

08.07.2019

Hesperos Inc., pioneers of the human-on-a-chip in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo. The findings support the potential of body-on-a-chip systems to transform the drug discovery process.
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Image: Remote-controlled implantable nanochannel drug delivery system besides a pen; Copyright: Houston Methodist

Implants: remote-controlled drug delivery system for chronic disease management

26.06.2019

People with chronic diseases like arthritis, diabetes and heart disease may one day forego the daily regimen of pills and, instead, receive a scheduled dosage of medication through a grape-sized implant that is remotely controlled.
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Image: cells are placed on a microfluidic organ-chip; Copyright: Dr. Gad Vatine/BGU

Blood-brain barrier chip: using stem cells for the first time

18.06.2019

Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
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Image: microscope images of the human Blood-Brain Barrier-on-Chip; Copyright: Wyss Institute at Harvard University

Blood-Brain Barrier Chip: in vivo-like drug and antibody transport

17.06.2019

Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
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Image: laboratory work; Copyright: panthermedia.net/Arne Trautmann

Diagnostics: biomarkers help tailor diuretic use in acute heart failure patients

31.05.2019

Adrenomedullin activity predicts which acute heart failure patients are at the greatest risk of death without diuretic treatment post-discharge, according to late breaking research presented today at Heart Failure 2019, a scientific congress of the European Society of Cardiology (ESC).
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Multi-organ chips: Drug research without animal testing at vasQlab

15.05.2019

New active substances that are suitable for drugs are initially tested in animal experiments. However, the results cannot always be transferred to the human organism. At the Karlsruhe Institute of Technology, Prof. Ute Schepers from vasQlab explains how active substances can be tested in human tissue without endangering human health.
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Image: A large number of round microwells on a plate; Copyright: Tetsuhiro Harimoto/Columbia Engineering

Precision medicine: bacterial therapy in a dish

26.04.2019

Columbia engineers develop a new platform that recreates cancer in a dish to quickly determine the best bacterial therapy.
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Image: A woman is drinking a glass of water; Copyright: panthermedia.net/Andriy Popov

Temperature-triggered devices for gastrointestinal therapies

24.04.2019

Gastrointestinal devices such as stents, endoscopic tubes, balloons and drug delivery systems can help clinicians treat patients with a range of conditions. But currently available methods for triggering where and when drugs are released or when a device is triggered to disassemble or change shape are often slow, which can restrict the utility of such tools.
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Image: Young girl uses an inhaler; Copyright: panthermedia.net/Craig Robinson

Inhalers: Critical errors common in children with asthma

23.04.2019

In the first study to evaluate inhaler technique in children hospitalized for asthma - the group at highest risk for complications and death from asthma - researchers found that nearly half of participants demonstrated improper inhaler use, which means they routinely were not taking in the full dose of medication.
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Image: Close-up of a woman with blue eyes wearing contact lenses; Copyright: Fraunhofer IAP

Drug delivery: contact lenses with medicine and sugar

22.04.2019

Researchers at the Fraunhofer Institute for Applied Polymer Research IAP are working with Israeli and German partners to develop long-wearing contact lenses that can release medicine. The active ingredient is encapsulated in liposomes and bound to the inside of the contact lenses. This enables it to remain in the eye for longer.
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Image: Dosage inhaler and stethoscope in front of a shelf; Copyright: panthermedia.net/liudmilachernetska@gmail.com

React early, breathe free – comprehensive COPD management

01.03.2019

COPD is considered the third most common cause of death worldwide and mainly affects smokers. It is not curable, but with the right combination of early diagnosis, therapy and self-management, a significant part of the quality of life can be regained. The comprehensive care is supported by various devices and technical tools. Learn more about the all-round care of COPD in our Topic of the Month.
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Image: senior coughing man with cigarette; Copyright: panthermedia.net/ljsphotography

All-round care for COPD: diagnosis, treatment, self-management

01.03.2019

COPD affects more than 200 million people in the world. Those affected by this chronic pulmonary disease are often slow to notice the symptoms and get a medical diagnosis. This results in secondary complications and high medical costs. That's why an early diagnosis, comprehensive treatment, and frequent monitoring are very important. Various devices and tools support this all-round care.
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Image: Preemie doll with drug delivery system on the nose; Copyright: Fraunhofer ITEM/Till Holland

Gentle medication for the little ones – with every breath

22.02.2019

According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
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Hybrid Imaging – Two Views of the Lungs

25.01.2019

CT scan, MRI or X-ray: All these methods allow doctors to see inside the body - including inside the lungs - and make a diagnosis. The clinic for Nuclear Medicine at the RWTH Aachen University Hospital uses a state-of-the-art gamma camera that combines SPECT and CT.
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Image: man holding his stomach; Copyright: panthermedia.net/ByLove

The cure is in the capsule: carbon monoxide to treat chronic inflammation

22.05.2018

This unusual ally can be extremely valuable in the fight against inflammation in the body: CO (carbon monoxide). As a therapeutic gas, it also promises relief for inflammatory gastrointestinal diseases. Having said that, it is difficult to transport the active ingredient to the exact desired location.
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research

22.02.2018

Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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Image: blood is taken from a finger and analysed by a blood testing device; Copyright:hes_so_valais_wallis

Without any delay: drug dose adjustment at the point of care

01.08.2017

Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
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Swallowing Disorders – avoiding errors related to medication administration

27.01.2017

Dysphagia creates a stressful situation for patients. Added to this is the fact that acute errors in the treatment of swallowing disorders keep occurring when patients are administered drugs. How can patients with swallowing difficulties receive better care? We visited the Hüttenhospital Dortmund and asked Dr. Martin Jäger, an expert in this particular field.
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