Respiratory viral pathogens caught on-site
16/04/2021
The research team also developed a 3D plasmonic array chip for multiplex molecular detections: a chip that can simultaneously analyze 8 pathogens (4 bacteria and 4 viruses).
Temperature sensor could help safeguard mRNA vaccines
06/04/2021
Scientists have developed vaccines for COVID-19 with record speed. The first two vaccines widely distributed in the U.S. are mRNA-based and require ultracold storage (-70 C for one and -20 C for the other).
Gamma ray camera could speed up cancer diagnosis
29/03/2021
Scientists have designed a portable 3D imaging device which will improve the treatment and diagnosis of cancer. Current handheld gamma imaging tools are small and easy to use, but are limited to providing 2D information, giving doctors and surgeons only part of the overall picture. Much larger systems are able to give three dimensional images, however, they are bulky and complex.
Zooming in on Muscle Cells
26/03/2021
Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, by using electron cryo-tomography (cryo-ET).
Researchers link breast cancer and bone growth
25/03/2021
A research team consisting of materials scientists from the Max Planck Institute of Colloids and Interfaces (MPICI) in Potsdam and biologists from Cornell University in Ithaca, USA revealed that bones may grow in response to certain signals from a distant breast tumor. This may be a preemptive defense mechanism against skeletal metastasis.
Biological device capable of computing by printing cells on paper
22/03/2021
The Research Group on Synthetic Biology for Biomedical Applications at Pompeu Fabra University in Barcelona, Spain, has designed a cellular device capable of computing by printing cells on paper. For the first time, they have developed a living device that could be used outside the laboratory without a specialist, and it could be produced on an industrial scale at low cost.
New method could democratize deep learning-enhanced microscopy
18/03/2021
Deep learning is a potential tool for scientists to glean more detail from low-resolution images in microscopy, but it is often difficult to gather enough baseline data to train computers in the process. Now, a new method developed by scientists at the Salk Institute could make the technology more accessible - by taking high-resolution images, and artificially degrading them.
Mobile and intelligent – emergency blood analysis
08/03/2021
Things need to move fast in an emergency. Making the right call in this setting can be a challenge for emergency medical services – especially when symptoms are ambiguous, which is the case if a patient has difficulty breathing or exhibits a cardiovascular or poisoning emergency. A blood analysis is paramount to deliver a fast and accurate diagnosis. This is where mobOx comes in.
Trialing a new COVID-19 test at the Royal Lancaster Infirmary
04/03/2021
A new, highly accurate COVID-19 test is being trialed at the Royal Lancaster Infirmary. Virus Hunter 6 (VH6) has been developed by Lancaster University in partnership with Brunel University London and the University of Surrey in collaboration with commercial partner Vidiia Ltd.
3D microscopy clarifies understanding of body's immune response to obesity
24/02/2021
Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity.
Cancer cells become fluidized and squeeze through tissue
22/02/2021
Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumor tissues and squeeze past neighboring cells.
Mass spectrometry: novel gel electrophoresis technique for rapid biomarker diagnosis
19/02/2021
Mass spectrometry (MS) is a powerful method for biomarker analysis because it enables highly sensitive and accurate measurement of target molecules in clinical samples. The application of MS to clinical diagnosis, such as neonatal metabolic screening, has been progressing with a focus on metabolite markers.
AI deciphers genetic instructions
19/02/2021
With the help of artificial intelligence (AI) a German-American team of scientists deciphered some of the more elusive instructions encoded in DNA. Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus providing a deeper understanding of how these sequences are organized to regulate genes.
Raman spectroscopy: European laboratories aim to create common standards
18/02/2021
Is the tissue healthy or pathologically altered? Is the antibiotic effective against a certain bacterium or is the bacterium resistant to it? Raman spectroscopy can help to answer such questions quickly and precisely. However, one challenge for the use of the light-based analysis method in everyday clinical practice is that the results can be highly sensitive to the measurement conditions.
Embryonic development in cell culture
15/02/2021
To study early stages in embryonic development in the cell culture dish, scientists use so-called human pluripotent stem cells (hPSC). These are cells with have remarkable special properties that can be multiplied as they can indefinitely multiply and are capable of forming any functional cell type of the body.
New device enables guided biopsies in real time
29/01/2021
A team from the Gamma and Neutron Spectroscopy Group of the Corpuscular Physics Institute (IFIC) has patented a new device for real-time guided biopsies, with direct application in any type of cancer that requires a biopsy and whose process must be carried out using ultrasound.
SARS-CoV-2: ultra-absorptive nanofiber swabs
28/01/2021
Rapid, sensitive diagnosis of COVID-19 is essential for early treatment, contact tracing and reducing viral spread. However, some people infected with SARS-CoV-2 receive false-negative test results, which might put their and others' health at risk.
Double antibody protects from SARS-CoV-2
27/01/2021
The Institute for Research in Biomedicine (IRB; Bellinzona, Switzerland), affiliated to the Università della Svizzera italiana (USI) developed a second-generation 'double antibody' that protects from SARS-CoV-2, the virus causing COVID-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy.
Tissue Engineering and Bioprinting – From artificial heart valves and printed humans
27/01/2021
Drug research and artificial skin replacement - these are the areas in which tissue engineering and bioprinting are already used today. What else could be possible in the future? We asked Dr. Nadine Nottrodt from Fraunhofer ILT and Prof. Sabine Neuß-Stein from RWTH Aachen University Hospital!
Fighting respiratory virus outbreaks through sensor-based rapid detection
25/01/2021
Viral respiratory diseases are easily transmissible and can spread rapidly across the globe, causing significant damage. The ongoing covid-19 pandemic is a testament to this. In the past too, other viruses have caused massive respiratory disease outbreaks: for example, a subtype of the influenza virus, the type A H1N1 virus, was responsible for the Spanish flu and the Swine flu outbreaks.
Signaling Strength between nerve cells depends on size of connections
22/01/2021
The neocortex is the part of the brain that humans use to process sensory impressions, store memories, give instructions to the muscles, and plan for the future. These computational processes are possible because each nerve cell is a highly complex miniature computer that communicates with around 10,000 other neurons. This communication happens via special connections called synapses.
Cancer diagnosis using a urine test with artificial intelligence
22/01/2021
Successful precision cancer diagnosis through an AI analysis of multiple factors of prostate cancer. Potential application of the precise diagnoses of other cancers by utilizing a urine test.
Blood group co-determines composition of the intestinal microbiome
21/01/2021
Chronic inflammatory bowel disease (CIBD) in particular is suspected to be closely linked to the composition and (im-)balance of the intestinal microbiome. However, the causal relationship between the microbiome and the development of disease and determining factors of the composition of the microbiome in the individual are still largely unexplained.
Cartilage matrix for cartilage regeneration
20/01/2021
Just a few millimetres thick, articular cartilage plays a crucial role in our musculoskeletal system, since it is responsible for smooth (in the truest sense of the word) movement. However, the downside of its particular structure is that even minor injuries do not regenerate. Timely treatment of cartilage damage is therefore essential.
Lasers and molecular tethers create platforms for tissue engineering
19/01/2021
Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.
Organoid Models: Illuminating Path to Cervical Cancers
19/01/2021
Organoids are increasingly being used in biomedical research. These are organ-like structures created in the laboratory that are only a few millimetres in size. Organoids can be used to study life processes and the effect of drugs. Because they closely resemble real organs, they offer several advantages over other cell cultures.
Alone in the lab – robot Kevin relieves the staff
08/12/2020
If Kevin was alone in the lab at night, the next morning, the workers will not find chaos, but labeled tubes and prepared samples. Kevin is a laboratory robot developed by Fraunhofer IPA to relieve the strain on laboratory workers so that they can concentrate on the essentials: research and diagnostics.
Multi-photon lithography: printing cells with micrometer accuracy
01/12/2020
How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
Printed life – possibilities and limits of bioprinting
01/12/2020
Implants, prostheses and various other components made of plastic, metal or ceramics are already being produced by additive manufacturing. But skin, blood vessels or entire organs from the printer – is that possible? For years now, intensive research has been underway into the production of biologically functional tissue using printing processes. Some things are already possible with bioprinting.
"Cells are highly sensitive" – material development for bioprinting
01/12/2020
The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
Bioprinting: life from the printer
01/12/2020
It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
The laboratory 4.0: networked analyses
01/09/2020
There is likely no other branch of medicine where you can find as many high-tech devices as in modern laboratories. A major part of diagnostic and biomedical research is done here. A lot of individual steps in work processes need to be followed precisely to ensure the results’ quality. Also, a lot of data is generated here.
The smart networking laboratory: when connected devices become one system
01/09/2020
Diagnostics, biomedical research, screening active ingredient candidates - laboratories perform many functions and must be flexible. Growing and evolving healthcare demands mean labs have to process an increasing number of samples. Modern laboratory information management systems can already support high-throughput, but a smart laboratory environment can make things even more efficient.
SmartLab: all-in-one automation, digitalization, and miniaturization
01/09/2020
Laboratories have to analyze and interpret an ever-increasing number of samples for research and diagnostic services, generating lots of data in the process. At the same time, labs are required to produce quality results and operate with speed. Processes that could once be managed using laboratory notebooks and isolated systems must become smart in the future to improve lab efficiency.
Augmented Reality for better laboratory results
01/09/2020
Accuracy is paramount in laboratory settings and ensures that lab results are valid. Errors in a lab can render series of tests unusable and waste precious time and money. In the medical realm, this might even result in clinical trial errors. Augmented reality (AR) can help laboratory technicians to prevent errors and guide their work in the future.
Israeli medical devices showcase digital innovations at MEDICA
24/08/2020
For the annual MEDICA trade fair, companies from all over the world assemble in Düsseldorf. The Israel Export Institute has been a part of it for the last couple of years. They present medical devices and digital innovations from different Israeli companies at their joint booth.
epiLab: Coronavirus testing in the mobile safety laboratory
08/07/2020
A key to preventing SARS-CoV-2 spread is frequent, comprehensive testing. This allows the early detection of infections and helps break the chain of infection. It always comes down to Coronavirus testing capacity. In Germany's southwest state of Saarland, the mobile epiLab (epidemiological laboratory) supports the search for infections lurking in nursing homes and long-term care facilities.
Sports medicine software: Monitoring at the push of a button
22/05/2020
Athletes not only have to be fit and stay in shape, but they also have to achieve peak performance, especially when they get ready for athletic events. Optimized and individualized performance training requires data from external laboratories and institutes. The [i/med] Sports platform from DORNER Health IT Solutions provides a complete workflow − from anamnesis to diagnostic report.
BSL-4 laboratories: highest levels of safety and protection
01/04/2020
Laboratories are sectioned into four biosafety levels to dictate the precautions required to isolate dangerous biological agents. The highest level of biological safety, BSL-4, is perhaps the most well-known when we think of containing pathogens and microbes. However, the fewest number of laboratories actually fall into the BSL-4 category.
Laboratory safety: infection prevention in the work area
01/04/2020
What goes in, must not come out - and must also not cause harm to anyone working inside the lab. That's perhaps a nice way of summing up "laboratory safety" in one sentence - at least wherever pathogens are handled in biological and medical settings. The necessary laboratory safety precautions primarily depend on what is waiting "inside".
Laboratory work: the right personal protective equipment is crucial
01/04/2020
When working with infectious materials and organisms in the laboratory, safe handling and appropriate training are of utmost importance. Another central component is personal protective equipment designed to prevent contact with tissue, liquids and aerosols and protect the wearer.
The safe laboratory – protection through technology
01/04/2020
When biomedical researchers or diagnosticians work with potentially contagious materials like cell cultures, blood or tissue, they need absolute protection from pathogens. Both safety measures in the workspace and the correct tools and materials are key here. Learn in our Topic of the Month what is important for protection in the lab and what a safe laboratory looks like.
Single-use tests: sensitivity and easy use combined for diagnostics
12/12/2019
Diagnostic testing usually takes some time and a sterile environment to get the results. To cut down on the costs and effort spend on these tasks there are different diagnostic tests. One of them are single-use tests offered by SensDx S.A. The technology behind them not only makes the process faster and easier, but provides the opportunity to expand into home use in the future as well.
Cardiac diagnostics – prompt and personalized
08/11/2019
If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
Medicine at the pulse of time: Innovations and trends at MEDICA 2019
04/11/2019
Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
MEDICA LABMED FORUM: full speed ahead for careers in laboratory medicine
04/11/2019
Laboratories are medicine’s secret weapon because they handle the lion’s share of diagnostics often without patients even realizing it. That’s why the continuing workforce shortage in both laboratory medicine and companies is especially troubling. The MEDICA LABMED FORUM 2019 plans to address and counteract this development.
AI software: "iSTIX opens your world to the possibilities of digital pathology"
08/10/2019
The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
MEDICA START-UP PARK: "For those, who want to experience the startup-spirit"
01/10/2019
When the halls of MEDICA are open to the world to showcase medical innovations, one joint exhibition booth is guaranteed to attract special attention - the MEDICA START-UP PARK. The startups that present their advances in this setting are interesting to visitors and investors, yet long-time exhibitors and big businesses can also benefit from building relationships with these young companies.
Cardiac Tissue Engineering: a heart out of the Petri dish
23/09/2019
For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
German Medical Award 2019 celebrates the future of (patient) care
22/08/2019
The German Medical Award will take place on November 18, 2019, as part of the MEDICA trade fair in Düsseldorf. The ceremony emphasizes the commitment to excellence in cutting-edge care for patients. Doctors, clinical centers and companies in the medical and healthcare industry can demonstrate their achievements in medicine and management in hopes of receiving the coveted award.
Tumor excision: triple imaging for unique diagnostics
08/08/2019
After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
Last-resort antibiotics: "We can identify carbapenemases within half an hour"
01/08/2019
Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
Antibiotic resistance: technical tricks against pathogens
01/08/2019
An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
Striking new paths in medicine - Diagnostics Partnering Conference 2019
08/07/2019
On November 18th, 2019, parallel to the first day of MEDICA, the world forum for medicine, the Diagnostics Partnering Conference (DxPx Conference) will take place in Düsseldorf, bringing together stakeholders in the diagnostics and research tool industry. The DxPx Conference focuses on discovering technologies, finding financing and investment opportunities and forming collaborative partnerships.
Organ-on-a-chip – Organs in miniature format
01/02/2019
In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
Multi-Organ Chips – The Patients of Tomorrow?
01/02/2019
The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
Organ-on-a-chip systems: limited validity?
01/02/2019
Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
From algorithm to rapid test – Artificial Intelligence classifies blood cells
21/11/2018
Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
Diagnostics at record speeds – POCT in high-performance sports
02/11/2018
This is what diagnostic investigation normally looks like: a patient sample is collected, sent to the laboratory and analyzed. Once that's completed, the patient is told of the lab test result. But if the patient is a high-performance athlete and has to follow and stick to a rigid training schedule, he or she needs these results immediately. What makes this possible? Point-of-care testing!
Back pain: The research project Ran Rücken is intended to help
10/09/2018
About eight in ten Germans suffer from back pain during their lifetime. Too much or the wrong movements can also cause problems. "Ran Rücken", the interdisciplinary research project aims to determine the right minimum dose of exercise that proves effective. (Explanatory note: "Ran Rücken" can be loosely translated as "Target the Back")
Pathology 4.0 – inveox automates laboratory processes
22/08/2018
Mix-ups, contamination and sample loss – most errors in pathology happen when specimen are received. Countless samples arrive daily at the laboratory, while the sample entry process is very monotonous. As a result, the work is inefficient. The start-up company inveox has now developed a system that automates the processes in the pathology laboratory, thus making them more efficient.
Personalized cancer medicine – Best possible treatment with TherapySelect
30/04/2018
Medicine is getting more and more personalized. This is particularly interesting for oncology, since a cancer is as individual as the respective patient. When choosing a therapy, both the characteristics of the tumor and the personal characteristics of the patient must be considered. To see exactly what this looks like, we visited the diagnostics company TherapySelect, based in Heidelberg.
On the trail of cancer: personalized cancer vaccine
01/03/2018
Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
Personalized cancer medicine: customized treatment
01/03/2018
Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
Cells in space – extraterrestrial approaches in cancer research
22/02/2018
Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
Everything flows: transportation and material flows in hospital logistics
01/02/2018
During a visit to the hospital, patients naturally expect to receive comprehensive care. Not only does this include the proper treatment, but also a hospital bed and regular meals for example. Patients typically don't ask about the transport logistics this entails for the hospital.
"Spray-On" muscle fibers for biomimetic surfaces
08/01/2018
Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.