The pathogenesis of CVD is a complicated process; however, recent research has revealed that responses to various types of
stress including mental stress and oxidative stress play an important role in the pathogenesis of these diseases. There has been
growing accumulating evidences that well-known atherosclerotic risk factors such as hypertension, diabetes, hyperlipidemia, and smoking can induce oxidative stress in the cardiovascular system. Under enhanced oxidative stress, low-density lipoprotein (LDL) is oxidatively modified. The formed oxidized LDL induces various biological activities that are related to atherosclerotic processes.
Oxidized LDL causes endothelial dysfunction, promotes the proliferation of vascular smooth muscle cells, and induces the expression of adhesion molecules and chemokines. These pathophysiological effects are mainly mediated via LOX-1. Recently, the Suita cohort investigation has revealed that a higher LOX-index, in which the LOX-1 ligands containing apolipoprotein B (LAB) and soluble LOX-1 (sLOX-1) were multiplied, was associated with an increased risk of CVD and stroke.
Thus, LOX-Index is a novel predictive marker for these diseases.
KRISHGEN is proud to launch the ELISA kits for measurement of
LOX Index ELISA
LAB (LOX-1 ligands containing Apolipoprotein B) ELISA
sLOX-1 (soluble LOX-1) ELISA
contact us at email: email@example.com to know more about these products
Exhibitor Data Sheet