Study Identifies Factors Correlated with Cerebral Palsy -- MEDICA - World Forum for Medicine

Martin Bax, D.M., of Imperial College London and Chelsea & Westminster Hospital, London, and colleagues examined the correlates of cerebral palsy (CP) in a population sample and compared clinical findings with information available from magnetic Resonance Imaging (MRI) brain scans. The study included 585 children with CP who were born between 1996 and 1999; 431 children were clinically assessed and 351 had a brain MRI scan at 18 months of age or later.

The researchers found that 39.5 percent (158 of 400) of the mothers reported an infection during the pregnancy, including 19.2 percent who reported a urinary tract infection and 15.5 percent who reported taking antibiotics during the pregnancy. Fifty-one children (12 percent) were known to be from a multiple pregnancy, with 48 from a twin pregnancy and 3 from a triplet pregnancy. This compares with a population rate of multiple pregnancy of about 1.5 percent. In addition, 235 children (54 percent) were born at term, whereas 47 children (10.9 percent) were very pre-term (born less than 28 weeks gestation), 69 (16 percent) were born between 28 and 31 weeks, and 79 (18.3 percent) were born between 32 and 36 weeks gestation. Emergency caesarean deliveries were performed in 32.3 percent of births.

Among children with clinical evaluation, 81.4 percent had a brain MRI scan assessed for the study. The scans showed that white-matter damage of immaturity was the most common finding (42.5 percent). Only 11.7 percent of these children had normal MRI findings. There were good correlations between the MRI and clinical findings.

“Not only do MRI scans help reveal the pathologic basis of the condition but, also, the findings have strong correlations with clinical findings. This may be useful in helping to understand the nature of the children’s condition and to predict their needs in the future. Therefore, all children with CP should have an MRI scan,” the authors write.; Source: American Medical Association (AMA)