Studying a group of children and adults in the Kilifi District of coastal Kenya, they found that this protection increased during childhood up to age ten, and then declined. Malaria causes about a million deaths yearly, the overwhelming number of which are young children in sub-Saharan Africa.
It has been known for many years that in those areas most afflicted by malaria the gene for sickle cell haemoglobin (HbS) occurs very frequently. The protection against malaria occurs in people who are heterozygote (HbAS), i.e., have one normal and one sickle gene, and previous work has suggested that there is an immune component to this protection.
To discover whether the protection provided by HbAS is innate or varies with age, the authors studied age-specific malaria in a sample of children and adults in the Kilifi District of coastal Kenya. Protection against mild malaria increased up to 60% at age ten, decreasing to 30% in older children.
Research into malaria has yet to yield an effective vaccine but this work may provide some insights for such research. The authors suggest mechanisms by which HbAS could affect immunity, for example, accelerated acquisition of antibodies to altered host proteins expressed on the malaria-infected red cell surface.
MEDICA.de; Source: Public Library Of Science