Background Reports 2020 -- MEDICA - World Forum for Medicine

Image: 3D illustration. Colorful DNA molecule. Conceptual image of a structure of the genetic code; Copyright: ktsimage

ktsimage

Sinonasal cancer: AI facilitates breakthrough in diagnostics

30/11/2022

Researchers at LMU and Charité hospital in Berlin have developed a method for classifying difficult-to-diagnose nasal cavity tumors.
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Image: Close-up: The complex architecture of the neuroepithelial organoids with cell membranes; Copyright: Keisuke Ishihara

Keisuke Ishihara

Measuring organ development

28/11/2022

Researchers from Dresden and Vienna reveal link between connectivity of three-dimensional structures in tissues and the emergence of their architecture to help scientists engineer self-organising tissues that mimic human organs.
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Image: A woman in the lab, Tina Bürki from Empa's Particles-Biology Interactions lab in St. Gallen, inspects a set of biochips; Copyright: Empa

Empa

Empa's Zukunftsfonds – Funding ambitious research: A chip to replace animal testing

24/11/2022

New drugs made from nanoparticles that can easily penetrate any interface within our bodies are a great hope in medicine. For such hopefuls to reach the market, their safety must be ensured. In this context, it must also be clarified what happens if a substance manages to penetrate the natural barrier between baby and mother, the placenta, in the body of pregnant women.
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Image: A small square apparatus, an electrochemical sensing platform for studying in vitro vascular systems. The channels and reservoirs were visualized using blue ink.; Copyright: Tohoku University

Tohoku University

Sensing platform for studying in vitro vascular systems

11/11/2022

The costliness of drug development and the limitations of studying physiological processes in the lab are two separate scientific issues that may share the same solution.
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Image: Mobile laboratory unit with integrated lifting device for a standard truck chassis; Copyright: Fraunhofer IBMT/Markus Michel

Fraunhofer IBMT/Markus Michel

MEDICA 2022: Biological laboratory to go

10/11/2022

Researchers from the Fraunhofer Institute for Biomedical Engineering IBMT have developed the “BioSensoLab“, a mobile biological laboratory with which they can demonstrate new developments to customers and test them together – on site at their companies.
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Image: An x-ray of the lungs showing a male hand pointing to a specific spot with a pen; Copyright: TNMDesign/Shutterstock

TNMDesign/Shutterstock

Small cell lung cancer: approach to personalised treatment

14/10/2022

A study led by MedUni Vienna has shown for the first time that different SCLC subtypes have specific molecular characteristics, which is why those affected respond in different ways to cancer treatment.
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Image: A shell made of polymers houses a photoresponsive molecule, which is irradiated with UV light and creates an opening; Copyright: MPI-P

MPI-P

How light can be used to control processes in synthetic cells

12/10/2022

Synthetic – i. e. artificially produced - cells can imitate certain functions of biological cells. These synthetic cells could open up new medical possibilities in the future.
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Image: The research team, consists of three men, poses in front of an institute building; Copyright: LIT

LIT

Synthetic biosensors reprogram Treg cells to tame autoimmunity and chronic inflammation

10/10/2022

Scientists from the Division of Immunology at the Leibniz Institute for Immunotherapy (LIT) have now developed new types of synthetic biosensors, so-called artificial immune receptors (AIRs), which can be used to reprogram Treg cells into intelligent "smart" Tregs.
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Image: Hand wearing blue gloves holding a multi-organ chip; Copyright: TissUse GmbH

TissUse GmbH

Multi-organ chip detects dangerous nanoparticles

10/10/2022

What happens when we breathe in nanoparticles emitted by a laser printer, for example? Could these nanoparticles damage the respiratory tract or perhaps even other organs? To answer these questions, Fraunhofer researchers are developing the "NanoCube" exposure device.
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Image: A woman in a white coat sits in the laboratory and smiles at the camera; Copyright: Alex Dolce, Florida Atlantic University

Alex Dolce, Florida Atlantic University

'Placenta-on-a-chip' mimics malaria-infected nutrient exchange between mother-fetus

30/09/2022

Researchers from Florida Atlantic University’s College of Engineering and Computer Science and Schmidt College of Medicine have developed a placenta-on-a-chip model that mimics the nutrient exchange between the fetus and mother under the influence of placental malaria.
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Image: Microbiologist during an inspection of a petri dish; Copyright: microgen

microgen

Muscle models mimic diabetes, inform personalized medicine

21/09/2022

Abnormally high blood sugar (glucose) levels can result in Type 2 diabetes when things go awry with the body's skeletal muscle, which plays a key role in regulating glucose.
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Image: Long structure of DNA double helix shown in dept; Copyright: ktsimage

ktsimage

Ten new risk genes for Crohn's disease

20/09/2022

The results of the international study involving the Cluster of Excellence PMI also point to a previously unknown process in the development of this chronic inflammatory bowel disease.
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Bild: Two men in lab coats, Dr. Robert Zweigerdt and Professor Dr. Ulrich Martin, talk in the laboratory on equipment for biotechnology; Copyright: Karin Kaiser / MHH

Karin Kaiser / MHH

New cells for the diseased heart

13/09/2022

EU funds research project on cell-based heart repair with 6.1 million euros.
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Image: Microscope in biotechnology laboratory with laboratory samples in the background; Copyright: ckstockphoto

ckstockphoto

Machine learning to unlock genomic code in clinical cancer samples

13/09/2022

A new paper from University of Helsinki, published in Nature Communications, suggests a method for accurately analysing genomics data in cancer archival biopsies.
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Image: Volker Bruns; Copyright: Fraunhofer ISS

Fraunhofer ISS

AI software: "iSTIX opens your world to the possibilities of digital pathology"

08/10/2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01/02/2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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