Background Reports 2019 -- MEDICA - World Forum for Medicine

Image: Female nurse looks at results on computer; Copyright: engagestock

engagestock

New computational tool to interpret clinical significance of cancer mutations

12/05/2022

The software, called CancerVar, standardizes procedures to help researchers assess the clinical impacts of over 13 million somatic cancer mutations.
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Image: Mikael Benson, professor at Linköping University ; Copyright: Thor Balkhed/Linköping University

Thor Balkhed/Linköping University

"Digital twins" aid to give individual patients the right treatment

11/05/2022

An international team of researchers have developed advanced computer models, or "digital twins", of diseases, with the goal of improving diagnosis and treatment.
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Image: 3D printed finger orthosis from 3Digity; Copyright: 3Digity

3Digity

Finger orthosis: Custom fit with 3D printing

10/05/2022

Following an injury or surgery, orthotics are key components of the recovery and rehabilitation process. The University spin-off 3Digity designs 3D-printed customized finger orthoses to foster rehabilitation as custom orthotics can drastically speed up the recovery process.
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Image: Three men and one woman in an OR - Bernd Auber, Alexander von Gise, Michael Sasse, Bettina Bohnhorst; Copyright: Karin Kaiser/MHH

Karin Kaiser/MHH

Rare diseases: rapid diagnosis instead of a long odyssey

26/04/2022

Can the treatment of seriously ill children with rare diseases be improved by rapid genetic diagnosis? This question is being investigated by a team from Pediatrics and Human Genetics at Hannover Medical School (MHH) in the "Baby Lion" study. The focus is on decoding the genome, i.e. the entire genetic information of a human being, in just a few days.
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Image: smartphone with diabetes app, in front lays the smart insulin pen; Copyright: Nico Arnold | diafyt MedTech

Nico Arnold | diafyt MedTech

Managing diabetes with diafyt thanks to self-learning and smart technology

22/04/2022

We all make mistakes from time to time or forget to do things. But people with diabetes can have serious health problems if they miscalculate or inject the wrong insulin dose. A research team from the Dresden University of Technology (TU Dresden) and a startup from Leipzig aim to make living with diabetes easier.
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Image: A MRI image of a heart arrhythmia; Copyright: Johns Hopkins University

Johns Hopkins University

AI predicts if - and when - someone will have cardiac arrest

15/04/2022

A new artificial intelligence-based approach can predict, significantly more accurately than a doctor, if and when a patient could die of cardiac arrest.
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Image: Man holds hand to his back with visualized visible spine; Copyright: PantherMedia / Wavebreakmedia

PantherMedia / Wavebreakmedia

Treating chronic pain phases with an AI-powered app

05/04/2022

The treatment of chronic and acute pain phases centers on the patient’s pain profile. The treatment strategies must be flexible to facilitate customized adjustments. The AI-powered pain treatment solution by medicalmotion offers support and makes individualized exercise recommendations to manage the individual needs of pain patients with neuromusculoskeletal disorders.
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Image: Man clutching his heart; Copyright: PantherMedia  / alexAleksei (YAYMicro)

PantherMedia / alexAleksei (YAYMicro)

AI enables personalized treatment of myocarditis

01/04/2022

A research team from the University of Bern and Inselspital, Bern University Hospital, has received funding from the Center for Artificial Intelligence in Medicine for a research project to personalize the diagnosis and treatment of myocarditis. In the future, the use of artificial intelligence will allow personalized, individualized risk assessment and prognostication.
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Image: Georgia Tech researcher Gabe Kwong poses for the camera Copyright: Georgia Tech photo

Georgia Tech photo

Biosensors for quick assessment of cancer treatment

16/03/2022

Immune checkpoint blockade (ICB) inhibitors have transformed the treatment of cancer and have become the frontline therapy for a broad range of malignancies. It’s because they work better than the previous standard of care.
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Image: Microscopic image of immune cells in the alveoli of a mouse.; Copyright: Sara Gholamhosseinian Najjar + Michaela Burkon

Sara Gholamhosseinian Najjar + Michaela Burkon

Cell therapy: Immune cells "forget culture shock" after laboratory stay

01/03/2022

A recent study shows that certain immune cells can restore their normal functions when introduced back into the body, even after being multiplied in the laboratory to large numbers – the results pave the way to new cell therapies.
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Image: A team of researchers during work; Copyright: Michael Short/Gladstone Institutes

Michael Short/Gladstone Institutes

Getting to the heart of complex disease

25/02/2022

Gladstone researchers develop robust strategy for sifting through large-scale genetic data to better understand congenital heart problems
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Image: Cardiac exam on a man; Copyright: PantherMedia / Dmyrto_Z

PantherMedia / Dmyrto_Z

Breakthrough study uses genetic testing to evaluate risk of heart disease

23/02/2022

Dignity Health in Arizona is the first in North America to launch this type of clinical trial.
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Image: Three Men, the founding team of aimed analytics ; Copyright: Sylvia Heckmair

Sylvia Heckmair

With AI to individual patient care

23/02/2022

How can a customized chemotherapy be found for cancer, for example? Machine learning methods can help with this and also improve patient treatment for other diseases. The start-up project aimed analytics at the University of Bonn has developed a modular analysis system that precisely groups patients on the basis of medical Big Data.
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Image: Keyboard with a share button; Copyright: PantherMedia / Niall Wiggan

PantherMedia / Niall Wiggan

Patients share their experiences

22/02/2022

What do people with multiple sclerosis, dementia or chronic pain go through? What are their experiences of medical practices or hospitals like? What kind of support do they find helpful? The new dipex.ch platform launched by Zurich researchers makes patient experience reports publicly available so that they can be used for research and teaching, to improve healthcare provision, or for self-help.
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Image: Person on a treadmill wears a smart watch which shows his or her heart rate; Copyright: PantherMedia/apid

More than trendy accessories: training optimization with the help of wearables

01/09/2021

Wearables are increasingly being used in sports medicine, for example, to prevent injuries or to provide users individually with real-time data about their fitness and health. By analyzing this data, risks for sports injuries can be identified early and training can be customized to the user's needs and goals.
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Image: woman holding an asthma inhaler in one hand and a smartphone in the other; Copyright: PantherMedia/microgen

Asthma: Self-management thanks to apps and wearables

11/01/2021

Today, managing one's own chronic disease is hardly possible without digital helpers – not least because of the corona pandemic. People with asthma also benefit from apps and wearables. They help patients connect better with doctors and better understand their own disease. Our Topic of the Month looks at why this is so important and what the digital services can do.
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Image: 3D printer with a human heart inside, next to a box with

Bioprinting: life from the printer

01/12/2020

It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
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Image: Transmission of medical data of an athlete to a laptop; Copyright: PantherMedia / Viktor Cap

PantherMedia / Viktor Cap

Sports medicine software: Monitoring at the push of a button

22/05/2020

Athletes not only have to be fit and stay in shape, but they also have to achieve peak performance, especially when they get ready for athletic events. Optimized and individualized performance training requires data from external laboratories and institutes. The [i/med] Sports platform from DORNER Health IT Solutions provides a complete workflow − from anamnesis to diagnostic report.
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Image: Computer-generated image of an arborizing blood vessel; Copyright: panthermedia.net/Ugreen

Angiogenesis: light shows blood vessels the way

03/02/2020

Regenerative medicine aims to replace damage in the body with functional tissue and restore normal function. The first defense for large defects are implants made of hydrogels, designed to promote cell growth. They need their own blood supply, which is a problem when it comes to larger implants because you cannot regulate where and how the blood vessels grow - until now.
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Image: Two knees of a woman next to each other, the left knee has a surgical suture; Copyright: panthermedia.net/wujekspeed

Regenerative medicine: creating a new body?

03/02/2020

Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
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Image: The shoulder of a man with a surgical suture; Copyright: panthermedia.net/JPCPROD

Regenerative medicine: helps the body healing

03/02/2020

Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
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Image: Digital twin of the lungs; Copyright: Ebenbuild/Jakob Richter

Ebenbuild/Jakob Richter

ARDS: Testing Consequences without Consequence

14/11/2019

Acute respiratory distress syndrome (ARDS) is a life-threatening illness in which the lungs are severely damaged. The condition always requires intensive medical care through mechanical ventilation. But not all lungs are the same. To ensure a personalized treatment that is adapted to the individual patient’s lung volume and condition, Ebenbuild relies on digital twins.
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Image: Blood sample labelled

panthermedia.net/olanstock

Cardiac diagnostics – prompt and personalized

08/11/2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Image: two athletes at the startline for a race; Copyright: panthermedia.net/vitalikradko

panthermedia.net/vitalikradko

Sports Hub project changes sports medicine with big data and AI

22/10/2019

Professor Jarek Krajewski sat down for a MEDICA interview and delivered a detailed description of the Sports Hub project. It highlights how big data and AI transform the world of sports medicine. The project delivers new insights and provides a versatile database.
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Image: Volker Bruns; Copyright: Fraunhofer ISS

Fraunhofer ISS

AI software: "iSTIX opens your world to the possibilities of digital pathology"

08/10/2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Participants of the German Medical Award 2018; Copyright: German Medical Award

German Medical Award

German Medical Award 2019 celebrates the future of (patient) care

22/08/2019

The German Medical Award will take place on November 18, 2019, as part of the MEDICA trade fair in Düsseldorf. The ceremony emphasizes the commitment to excellence in cutting-edge care for patients. Doctors, clinical centers and companies in the medical and healthcare industry can demonstrate their achievements in medicine and management in hopes of receiving the coveted award.
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Image: close-up of a woman lying in an MRI device; Copyright: panthermedia.net/Craig Robinson

Brain mapping: preoperative planning with functional MRI

01/04/2019

A surgery already begins before the patient is lying on the operating table – namely with the planning. For example, if brain surgery is imminent, the brain must first be mapped. This makes the activity level of certain brain areas visible. Functional magnetic resonance imaging makes this possible.
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Image: Patient during an fMRI examination; Copyright: panthermedia.net/Chris De Silver

Functional imaging: what makes the brain tick?

01/04/2019

Our brain is the command center of our body. This is where all information and impressions are collected and converted into responses and movements. Modern imaging techniques offer physicians and researchers unique insights into the actions of the human central nervous system. The functional imaging technique allows them to watch our brain in action.
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Picture: Woman sleeping sideways in bed with a breathing mask; Copyright: Philips GmbH

Comprehensive Treatment: It’s All About Breathing

01/03/2019

Coughing, airway obstruction, difficulty breathing: Chronic obstructive pulmonary disease (COPD) is an umbrella term used to describe progressive and currently incurable lung diseases. The innovative solutions of Philips Respironics help patients to manage each stage of the disease and their medication intake, train the respiratory system and provide respiratory support.
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Image: senior coughing man with cigarette; Copyright: panthermedia.net/ljsphotography

All-round care for COPD: diagnosis, treatment, self-management

01/03/2019

COPD affects more than 200 million people in the world. Those affected by this chronic pulmonary disease are often slow to notice the symptoms and get a medical diagnosis. This results in secondary complications and high medical costs. That's why an early diagnosis, comprehensive treatment, and frequent monitoring are very important. Various devices and tools support this all-round care.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Sock TelePark; Copyright: Marc Eisele, University Hospital Dresden

Marc Eisele, Universitätsklinikum Dresden

Better living thanks to telemedicine – "TelePark"- project targets patients with Parkinson’s disease

08/01/2019

Parkinson's disease is a progressive nervous system disorder that primarily affects movement of patients and makes their everyday lives very challenging. It also makes regular doctor appointments and treatment sessions necessary. "TelePark" - a project that collects different movement-related parameters using sensors and apps is designed to improve the quality of life for Parkinson’s patients.
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Image: digital capture of an eye; Copyright: panthermedia.net / cosmin momir

A digital look inside the human eye – when algorithms diagnose Diabetes

02/01/2019

Diabetes mellitus or simply diabetes has become very common and is often described as a lifestyle disease. More and more people are suffering from this chronic metabolic disorder. Next to established diagnostic procedures, digital retinal screening has shown to be successful - a promising technique that will also play an important role in the diagnosis of other diseases in the future.
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Image: Woman puts her arms around the retina scanner and looks smilingly to the side into the camera; Copyright: Mimo AG

Mimo AG

Collect, process, communicate – retina measurements with Mimo

19/12/2018

Continuous monitoring is an essential process with every disease. In the case of eye disorders, frequent retina measurements can facilitate early detection of deterioration to quickly initiate intervention. This calls for comprehensive care settings, easy ways to take measurements and prompt results. However, in reality, this is rarely the case.
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Image: Proband with a neuroprosthesis; Copyright: MoreGrasp

MoreGrasp

MoreGrasp – being able to grasp again with paraplegia

22/11/2018

Every year between 250.000 and 500.000 people suffer a spinal cord injury, MoreGrasp is intended to make their lives easier. The project aims to restore the lost gripping function in people with high paraplegia. Researchers at Graz University of Technology have developed a neuroprosthesis that is currently undergoing a feasibility study.
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Image: the model of a kidney with gripping tools and the adhesive; Copyright: Purenum GmbH

Purenum GmbH

A clean kidney: Break then glue

08/11/2018

Not enough exercise, an unhealthy diet: Kidney stones develop when urine contains too many insoluble compounds and are now one of the most common diseases worldwide. The ailment annually affects 1.2 million people in Germany alone. The stones are broken up and taken out via endoscopic surgery. Now it’s possible to remove even the tiniest residual fragments. The solution: a biocompatible adhesive.
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Image: Stetoscope lies on an EGK; Copyright: panthermedia.net / BrianAJackson

panthermedia.net / BrianAJackson

Healthy aging: further research needed on measurement methods in geriatrics

22/10/2018

Today’s society is faced with an aging population. The past has seen the development of many methods for measuring body composition in older adults. However, some of these techniques are not available to medical practices and hospital facilities or are in dire need of optimization.
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Image: Silhouette of a woman walking up a staircase by the sea; Copyright: panthermedia.net/lzf

panthermedia.net/lzf

Exercise Prescription for Health: sports instead of pills

08/10/2018

Did you know that we can influence up to 50 percent of our health ourselves? If we eat a balanced diet and exercise regularly, this not only ensures longer independence in old age. Diseases can also be treated with exercise. But in many cases, physicians and patients still rely more on medication than on exercise.
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Image: About eight in ten Germans suffer from back pain during their lifetime; Copyright: panthermedia.net/stasique

panthermedia.net/stasique

Back pain: The research project Ran Rücken is intended to help

10/09/2018

About eight in ten Germans suffer from back pain during their lifetime. Too much or the wrong movements can also cause problems. "Ran Rücken", the interdisciplinary research project aims to determine the right minimum dose of exercise that proves effective. (Explanatory note: "Ran Rücken" can be loosely translated as "Target the Back")
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Image: Two hands are holding a tubular frame that is carrying a glistening wet, white tube; Copyright: Leibniz University of Hanover/Institute of Technical Chemistry

Leibniz University of Hanover/Institute of Technical Chemistry

Tissue engineering: how to grow a bypass

23/04/2018

A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
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