Background Reports 2019 -- MEDICA - World Forum for Medicine

Image: Two men in white coats, Dr. Gregor Hageluken and Dr. Martin Peter, are in the laboratory and examine pathogens; Copyright: UKB

UKB

Bacterial membrane transporter helps pathogens to hide from immune system

10/08/2022

The transport of substances across the membrane into the cell is linked to specific membrane transport proteins. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with an international team, have now succeeded in elucidating the molecular structure of a completely new class of such membrane transporters.
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Image: Person in the laboratory holding cell samples under a microscope; Copyright: MICROGEN@GMAIL.COM

MICROGEN@GMAIL.COM

Molecular markers: predicting the most effective treatment for IBD

09/08/2022

Early effective treatment can help manage this condition and improve the quality of life of patients. A research project aims to identify molecular markers to better assess the chances of success of certain biological therapies and subsequently determine the best individualized treatment plan.
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Image: Illustration of cells and transfection variants; Copyright: Dr. Holger Erfle, University of Heidelberg, BIOQUANT

Dr. Holger Erfle, University of Heidelberg, BIOQUANT

Cell-protecting transfection of proteins and other macromolecules into living cells

04/08/2022

"Top-fase" is a simple and universal tool for the targeted transfection of numerous molecule species into cells and cell lines.
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Image: A man with brown skin and curly black hair receives a nose swab; Copyright: Prostock-Studio

Prostock-Studio

New COVID-19 rapid-test performs PCR faster than similar tests

29/07/2022

Researchers at Columbia Engineering and Rover Diagnostics team up to develop a low-cost, portable platform that gives RT-PCR results in 23 minutes that match laboratory-based tests.
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Image: A drone in front of a city landscape with skyscrapers; Copyright: IZF

IZF

Are drones the optimal way to distribute COVID-19 tests?

29/07/2022

Researchers are looking into drone delivery as a method to efficiently deliver testing kits while limiting contact between individuals.
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Image: A man in a white coat speaking to a woman in black t-shirt and demonstrates his biosensor; Copyright: Chris Meyer, Indiana University

Chris Meyer, Indiana University

Fast, efficient COVID-19 biosensor under development

27/07/2022

Researchers are improving technology to test for the coronavirus at a 'population scale' in order to stay on top of shifting variants.
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Image: Woman collecting blood samples for testing on different diseases; Copyright: Prostock-studio

Prostock-studio

Biomarkers: Early detection of Tuberculosis in people with HIV

26/07/2022

Findings of the LMU University Hospital Munich, the German Center for Infection Research (DZIF) and the U.S. Military HIV Research Program in collaboration with the African Cohort Study (AFRICOS) Group suggest that blood-based biomarkers can often detect incipient Tuberculosis (TB) between six to twelve months earlier in people living with HIV before a sputum-based TB diagnosis is possible.
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Image: Photographed microscope in a laboratory; Copyright: svitlanah

svitlanah

Individual cells are smarter than thought

25/07/2022

Humans make decisions based on various sensory information which is integrated into a holistic percept by the brain. But how do single cells make decisions? Much more autonomously than previously thought, as researchers from the University of Zurich have now shown.
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Image: Empty laboratory tubes for diagnosis of coronavirus disease; Copyright: rawf8

rawf8

Skins swabs could be how we test for Covid-19 in the future

22/07/2022

Skin swabs are "surprisingly effective" at identifying Covid-19 infection,according to new research from the University of Surrey, offering a route to a non-invasive future for Covid-19 testing.
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Image: Researchers work in a laboratory with a microscope and a laptop; Copyright: ckstockphoto

ckstockphoto

How to find marker genes in cell clusters

08/07/2022

New method facilitates identification of cell-type specific genes in single-cell data: The thousands of cells in a biological sample are all different and can be analyzed individually, cell by cell.
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Image: A cell cultured on top of the nanowire scaffold.; Copyright: 2022 KAUST; Heno Hwang

2022 KAUST; Heno Hwang

Bone formation comes down to the nanowire

08/07/2022

A nanotechnology platform developed by KAUST scientists could lead to new treatments for degenerative bone diseases.
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Image: Visualization of a miRNA expression using DNA computing and nanopore decoding; Copyright: Tokyo University of Agriculture and Technology

Tokyo University of Agriculture and Technology

Detection of cancer biomarkers using nanopore-based DNA computing technology

05/07/2022

Cholangiocarcinoma, also known as bile duct cancer, is a cancer type with a characteristically high mortality. At the time of diagnosis, most bile duct cancers are typically already incurable. This is why methods for the early diagnosis of bile duct cancer are urgently needed.
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Image: Yujin Hoshida poses for the camera; Copyright: UT Southwestern Medical Center

UT Southwestern Medical Center

Blood test to predict liver cancer risk

04/07/2022

Protein levels in blood samples of patients with nonalcoholic fatty liver disease reveal those at highest risk who should be screened regularly for liver cancer.
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Image: Blut sample in a test tube; Copyright: gpointstudio

gpointstudio

New blood biomarker identified for status of fatty liver disease

29/06/2022

A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease.
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Image: Empty laboratory tubes for diagnosis of coronavirus disease; Copyright: rawf8

rawf8

Rapid test to measure immunity to COVID-19

17/06/2022

New blood assay provides critical information for revaccination strategies in vulnerable individuals.
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Image: Man in a suit and glasses poses for the camera; Copyright: Klaus Nagels

Klaus Nagels

Precise blood diagnostics improve treatment outcome for lung cancer

10/06/2022

Non-small cell lung carcinoma is a particularly aggressive type of lung cancer. Tumor cells and tumor DNA (ctDNA) in the blood of patients with the disease can be analyzed by means of liquid biopsy throughout the course of the disease.
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Image: Ceren Kimna, doctoral candidate at TUM and first author of the study, examines the biomolecular film in the laboratory. ; Copyright: Astrid Eckert / TUM

Astrid Eckert / TUM

Multi-functional bandage helps wounds to heal

08/06/2022

Researchers at the Technical University of Munich (TUM) have developed a film that not only protects wounds similar to the way a bandage does, but also helps wounds to heal faster, repels bacteria, dampens inflammation, releases active pharmaceutical ingredients in a targeted manner and ultimately dissolves by itself.
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Image: Researcher doing lab tests on white blood cell samples; Copyright: Prostock-studio

Prostock-studio

Magnetic device isolates rarest white blood cells

27/05/2022

Across the world, food allergies are on the rise. One of the most important cells in studying this ailment are basophils, which activate inflammation and other responses to allergens such as rashes, and sometimes, anaphylaxis.
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Image: Drawn schematic of a work flow in a laboratory; Copyright: Juliet Percival/MPI für Biochemie

Juliet Percival/MPI für Biochemie

New method revolutionizes cancer diagnosis

24/05/2022

A German-Danish team led by Prof. Matthias Mann has developed a ground-breaking technology called 'Deep Visual Proteomics'. This method provides researchers and clinicians with a protein read-out to understand cancer at single cell-type resolution. The technology was published in the journal Nature Biotechnology and demonstrates its potential in a first application to cancer cells.
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A diagram intended to illustrate genetic manipulation of the female reproductive tract ; Copyright: AG Chumduri

AG Chumduri

Cervix: Research progress thanks to mini organs

23/05/2022

Life-like organ replicas - so-called 3D organoids - are a good way to research disease processes. A team from the University of Würzburg has now presented a kind of blueprint for such a model of the cervix.
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Image: A three-dimensional view of cell activities of skin cancer squamous cell carcinoma.; Copyright: M. Schober/E. Fuchs, Rockefeller University

M. Schober/E. Fuchs, Rockefeller University

New method melds data to make a 3-D map of cells’ activities

20/05/2022

HZI researchers develop molecular probes to detect pathogens in clinical samples.
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Image: Electron micrograph of Staphylococcus aureus; Copyright: HZI/Manfred Rohde

HZI/Manfred Rohde

A bright spot for microbiological diagnostics

19/05/2022

HZI researchers develop molecular probes to detect pathogens in clinical samples.
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Image: Assembly of biochips with attached tubes; Copyright: Fraunhofer ILT, Aachen

Fraunhofer ILT, Aachen

Process chains for isolation and analysis: from single cells to organoids

17/05/2022

Researchers at the Fraunhofer Institute for Laser Technology ILT are working on new tools for the preparation and analysis of single cells and cell assemblies. The team developed the "Liftoscope", a system for cell sorting for subsequent cultivation that can analyze and transfer biomaterials precisely and in a way that is gentle on cells.
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Image: A man wearing VR glasses stands in front of a screen and looks at a protein structure; Copyright: The University of Texas at San Antonio

The University of Texas at San Antonio

Virtual reality to give UTSA students unique look at proteins

16/05/2022

Francis Yoshimoto, assistant professor in the UTSA College of Sciences’ Department of Chemistry, is introducing his Biochemistry II laboratory students to a new way of learning—using virtual reality headsets to observe and analyze protein structures.
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Image: diagnostic test on a table; Copyright: beta web GmbH/Melanie Prüser

beta web GmbH/Melanie Prüser

Single-use tests: sensitivity and easy use combined for diagnostics

12/12/2019

Diagnostic testing usually takes some time and a sterile environment to get the results. To cut down on the costs and effort spend on these tasks there are different diagnostic tests. One of them are single-use tests offered by SensDx S.A. The technology behind them not only makes the process faster and easier, but provides the opportunity to expand into home use in the future as well.
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Image: Blood sample labelled

panthermedia.net/olanstock

Cardiac diagnostics – prompt and personalized

08/11/2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Image: Flags are blowing in the wind to the backdrop of a dark evening sky; Copyright: Messe Düsseldorf/ctillmann

Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04/11/2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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Image: A little toy figure of a man in a suit is standing on a print-out of DNA sequencing; Copyright: panthermedia.net/filmfoto

MEDICA LABMED FORUM: full speed ahead for careers in laboratory medicine

04/11/2019

Laboratories are medicine’s secret weapon because they handle the lion’s share of diagnostics often without patients even realizing it. That’s why the continuing workforce shortage in both laboratory medicine and companies is especially troubling. The MEDICA LABMED FORUM 2019 plans to address and counteract this development.
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Image: Volker Bruns; Copyright: Fraunhofer ISS

Fraunhofer ISS

AI software: "iSTIX opens your world to the possibilities of digital pathology"

08/10/2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Image: MEDICA START-UP PARK; Copyright: Messe Düsseldorf/ctillmann

MEDICA START-UP PARK: "For those, who want to experience the startup-spirit"

01/10/2019

When the halls of MEDICA are open to the world to showcase medical innovations, one joint exhibition booth is guaranteed to attract special attention - the MEDICA START-UP PARK. The startups that present their advances in this setting are interesting to visitors and investors, yet long-time exhibitors and big businesses can also benefit from building relationships with these young companies.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Participants of the German Medical Award 2018; Copyright: German Medical Award

German Medical Award

German Medical Award 2019 celebrates the future of (patient) care

22/08/2019

The German Medical Award will take place on November 18, 2019, as part of the MEDICA trade fair in Düsseldorf. The ceremony emphasizes the commitment to excellence in cutting-edge care for patients. Doctors, clinical centers and companies in the medical and healthcare industry can demonstrate their achievements in medicine and management in hopes of receiving the coveted award.
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Image: Laboratory situation - Prof. Popp shows a young man a small object in his hand; Copyright: Leibniz-IPHT/Sven Döring

Leibniz-IPHT/Sven Döring

Tumor excision: triple imaging for unique diagnostics

08/08/2019

After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
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Image: Two petri dishes with different kinds of agar plates on which bacterial cultures are growing; Copyright: panthermedia.net/photographee.eu

Antibiotic resistance: technical tricks against pathogens

01/08/2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: panthermedia.net/Arne Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"

01/08/2019

Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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Image: Flags; Copyright: SilverSky LifeSciences GmbH

SilverSky LifeSciences GmbH

Striking new paths in medicine - Diagnostics Partnering Conference 2019

08/07/2019

On November 18th, 2019, parallel to the first day of MEDICA, the world forum for medicine, the Diagnostics Partnering Conference (DxPx Conference) will take place in Düsseldorf, bringing together stakeholders in the diagnostics and research tool industry. The DxPx Conference focuses on discovering technologies, finding financing and investment opportunities and forming collaborative partnerships.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01/02/2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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