Background Reports 2019 -- MEDICA - World Forum for Medicine

Image: early-stage cancer detection blood test with diagnostic equipment; Copyright: CanSense

AI blood test detects early signs of bowel cancer


A new blood test developed in Wales harnesses the power of artificial intelligence to detect the early signs of bowel cancer – a disease that affects over 260,000 people in the UK today. CanSense, a Swansea University-spin out, has spent seven years developing a cancer test that can be performed at local GPs to avoid lives lost through delayed detection.
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Image: data epiction of cancer; Copyright: Ella Maru Studio/MPI f. Mol. Genet.

New cancer genes identified with the help of machine learning


In cancer, cells get out of control. They proliferate and push their way into tissues, destroying organs and thereby impairing essential vital functions. This unrestricted growth is usually induced by an accumulation of DNA changes in cancer genes – i.e. mutations in these genes that govern the development of the cell.
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Image: 3D flurescent model; Copyright: A*STAR, IBN, SIAMH

3D organoid models to fine-tune radiation dose for cancer


First of its kind 3D organoid models of nasopharyngeal cancer help to fine-tune radiation doses, and lower the chances of Nasopharyngeal Cancer recurrence and reduce mortality rate.
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Image: flowchart; Copyright: Steven Offer

New computational models to understand colon cancer


Although the development of secondary cancerous growths, called metastasis, is the primary cause of death in most cancers, the cellular changes that drive it are poorly understood. In a new study researchers at the University of Illinois Urbana-Champaign have developed a new modeling approach to better understand how tumors become aggressive.
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Image: a person being scanned with a camera; Copyright: Loughborough University

Gamma ray camera could speed up cancer diagnosis


Scientists have designed a portable 3D imaging device which will improve the treatment and diagnosis of cancer. Current handheld gamma imaging tools are small and easy to use, but are limited to providing 2D information, giving doctors and surgeons only part of the overall picture. Much larger systems are able to give three dimensional images, however, they are bulky and complex.
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Image: an asbestos warning sign; Copyright: PantherMedia / carrollmt

AI used in battle against asbestos-linked cancer


International genomics research led by the University of Leicester has used artificial intelligence (AI) to study an aggressive form of cancer, which could improve patient outcomes.
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Image: micrograph of a bone cross-section; Copyright: MPICI

Researchers link breast cancer and bone growth


A research team consisting of materials scientists from the Max Planck Institute of Colloids and Interfaces (MPICI) in Potsdam and biologists from Cornell University in Ithaca, USA revealed that bones may grow in response to certain signals from a distant breast tumor. This may be a preemptive defense mechanism against skeletal metastasis.
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Image: different images of purple highlighted tumors; Copyright: Pantazis Lab, Imperial College London

Tumours illuminated with new biodegradable nanoprobe


To highlight tumours in the body for cancer diagnosis, doctors can use tiny optical probes (nanoprobes) that light up when they attach to tumours. These nanoprobes allow doctors to detect the location, shape and size of cancers in the body.
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Image: a medical unltrasonic of a womans upper body; Copyright: PantherMedia / Arne Trautmann

AI-based diagnostic system for breast cancer


Researchers at TU Berlin and Charité – Universitätsmedizin Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI).
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Image: ultrasound testing; Copyright: PantherMedia / Zsolt Nyulaszi

New cancer scan could guide brain surgery


The new ultrasound technique, called shear wave elastography, could be used during brain surgery to detect residual cancerous tissue, allowing surgeons to remove as much as possible.
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Image: regenerative tissue filler for breast conserving surgery; Copyright: Sherry Harbin/Purdue University

Tissue, scaffold technologies provide new options for breast cancer


New technology from Purdue University innovators may help improve tissue restoration outcomes for people with breast cancer and other diseases or traumatic injuries.
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Image: Back of person with moles that are marked in different colors; Copyright: Luis R. Soenksen

Neural network could help clinicians look for pre-cancerous skin lesions


A neural network system that analyzes photographs can rank and distinguish suspicious, potentially precancerous skin lesions, which can turn into the deadly skin malignancy melanoma if not caught and removed early.
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Image: A cell cluster with green and red colored cells; Copyright: Universität Leipzig

Cancer cells become fluidized and squeeze through tissue


Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumor tissues and squeeze past neighboring cells.
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Image: Man is holding a plastic model of the colon in front of his stomache; Copyright: PantherMedia/benschonewille

Take-at-home tests boost colorectal cancer screening for the underserved


Colorectal cancer screening rates jumped by more than 1,000 percent when researchers sent take-at-home tests to patients overdue for testing at a community health center that predominantly serves people of color.
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Image: A female researcher is sitting in front of a screen showing a DNA helix; Copyright: PantherMedia/Lev Dolgachov

Platform identifies cancer mutations that may be responsive to drug therapies


A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published in Genome Biology.
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Image: laser-based, multimodal imaging techniques; Copyright: Sven Döring / Leibniz-IPHT

Laser light detects tumors


Cancer - this diagnosis is hitting more and more people in our aging society. But the earlier the disease is detected, the greater the likelihood that it can be treated effectively. Modern light-based technologies can help to decisively improve the diagnosis and treatment of cancer, because they can produce diagnostically relevant information quickly, reliably and gently.
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Image: two men and a woman in white tshirts are standing in front of a white ground, they're wearing cancer ribbons; Copyright: PantherMedia/Andrew Lozovyi

World Cancer Day 2021


Everyone knows it, everyone has heard of it: cancer. It is still one of the most common causes of death. Every year on 4 February, the World Cancer Organisation draws attention to this issue with World Cancer Day. By providing information, it gives hope to sufferers and non-affected people on how to take preventive action against the disease.
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Image: Artist’s rendering of small star-shaped machines between red blood cells; Copyright: PantherMedia/Michael Osterrieder

Autonomous medical devices: running well in your body


In theory, autonomous medical technologies can be used in a diagnostic or therapeutic capacity inside the body under certain conditions. This may not sound like a new invention at first. After all, implantable cardioverter-defibrillators have monitored and fixed abnormal heart rhythm for many years.
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Image: Two small, angular-shaped, electrical devices that are held with tweezers; Copyright: Fraunhofer EMFT/Bernd Müller

Tumor therapy: drug delivery pump instead of injection


Drugs always have undesired side effects. Cytostatics are powerful drugs used to treat cancer. They reach almost all cells in the body, killing healthy cells as well as cancer cells in the process. A targeted delivery to the specific cellular site would be a gentler treatment.
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Image: doctor with tablet; Copyright: ipopba/

AI: individualized cancer therapy soon to be faster


The treatment of cancer with new, individualized cell therapies is usually very costly and lengthy. Before treatment can take place, patients often have to wait a long time for individualized therapeutics to be produced and they lose valuable time.
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Image: doctor looks at ultrasound images; Copyright: Asociación RUVID

New device enables guided biopsies in real time


A team from the Gamma and Neutron Spectroscopy Group of the Corpuscular Physics Institute (IFIC) has patented a new device for real-time guided biopsies, with direct application in any type of cancer that requires a biopsy and whose process must be carried out using ultrasound.
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Image: testing urine samples using ultra-high-sensitive smart biosensors; Copyright: Korea Institute of Science and Technology (KIST)

Cancer diagnosis using a urine test with artificial intelligence


Successful precision cancer diagnosis through an AI analysis of multiple factors of prostate cancer. Potential application of the precise diagnoses of other cancers by utilizing a urine test.
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Image: Image of human cervix tissue and organoids derived from ectocervical stratified squamous and endocervical columnar epithelial stem cells; Copyright: JMU

Organoid Models: Illuminating Path to Cervical Cancers


Organoids are increasingly being used in biomedical research. These are organ-like structures created in the laboratory that are only a few millimetres in size. Organoids can be used to study life processes and the effect of drugs. Because they closely resemble real organs, they offer several advantages over other cell cultures.
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Image: Laboratory situation - Prof. Popp shows a young man a small object in his hand; Copyright: Leibniz-IPHT/Sven Döring

Tumor excision: triple imaging for unique diagnostics


After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
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Image: visitors at MEDICA; Copyright: Messe Düsseldorf

See, experience, learn: what's new at MEDICA 2018


It's time: the world's largest medical trade fair opens its doors from 12 to 15 November. More than 5,000 international exhibitors will present their new innovative products and applications. Frums, conferences and special shows will feature exciting specialist lectures and discussions that will give you an insight into electromedicine, laboratory medicine, medical technology and diagnostics.
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Image: diagnosis of the lung; Copyright: Nivens

With modern imaging supplies: A look into the lung


Thanks to various imaging supplies, it is possible to make the inside of the body accessible for diagnostics, research and treatment. The lung, one of the most important human organs for survival, is also examined in this way. In our Topic of the Month, we looked at how doctors are getting a closer look at the lung, how the procedures differ, and which ones will be available in the near future.
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Image: Small brown mole on the back of a hand; Copyright: Hahn

Early detection: Tattoo signals cancer – and more


People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
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Photo: Preview picture of video

Personalized cancer medicine – Best possible treatment with TherapySelect


Medicine is getting more and more personalized. This is particularly interesting for oncology, since a cancer is as individual as the respective patient. When choosing a therapy, both the characteristics of the tumor and the personal characteristics of the patient must be considered. To see exactly what this looks like, we visited the diagnostics company TherapySelect, based in Heidelberg.
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Image: DermaFC developed by Magnosco; Copyright: Magnosco

A startup makes melanin glow: skin cancer diagnostics with Magnosco


When a skin lesion is suspected to exhibit malignant changes, it is usually promptly removed. However, not all cases require an excision of the affected tissue. The startup company Magnosco has developed a procedure that uses a laser to support the diagnosis and early detection of malignant melanoma.
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Image: Man with stethoscope and medical symbols; Copyright:

Between austerity measures and growth pressure - Latin America's medical market


A region whose states make up the world's third largest economy and which has few linguistic differences - Latin America is an attractive market for foreign companies at first glance. This also applies to the medical market. However, various factors are contributing to the fact that this market is growing only slowly in most countries.
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Image: A group of physicians is holding large colorful puzzle pieces in their hands and is putting them together; Copyright: Popov

Personalized medicine: a paradigm shift is gaining momentum


Personalized medicine does not follow a "one-size-fits-all" treatment approach but emphasizes a "tailor-made" paradigm, meaning a treatment is customized to each individual person's case. For patients, this increases the chances of treatment success and means fewer side effects. While the approach originates in the field of oncology, it is now also increasingly applied to other disease patterns.
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Image: Three men in suits and a woman in a laboratory coat are standing in a laboratory; Copyright: Ministry of Economy of Mecklenburg-Hither Pomerania/Norbert Fellechner

On the trail of cancer: personalized cancer vaccine


Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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Image: yellow tape measure with capsules in front of it; Copyright: Hera

Personalized cancer medicine: customized treatment


Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research


Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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