Background Reports 2019 -- MEDICA - World Forum for Medicine

Image: Close-up of a male chest-shoulder area with a tattoo-like drawing on the skin that is supposed to represent a gene cluster; Copyright: Polygraph Design

Polygraph Design

How genes and small molecules influence personal disease risk

25/11/2022

In an international collaboration with partners from Cambridge (UK), scientists from the Berlin Institute of Health at the Charité (BIH) have now discovered more than 300 regions in the genome that contribute to this individual chemical fingerprint. They have now published their results in Nature Medicine.
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Image: A woman in the lab, Tina Bürki from Empa's Particles-Biology Interactions lab in St. Gallen, inspects a set of biochips; Copyright: Empa

Empa

Empa's Zukunftsfonds – Funding ambitious research: A chip to replace animal testing

24/11/2022

New drugs made from nanoparticles that can easily penetrate any interface within our bodies are a great hope in medicine. For such hopefuls to reach the market, their safety must be ensured. In this context, it must also be clarified what happens if a substance manages to penetrate the natural barrier between baby and mother, the placenta, in the body of pregnant women.
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Image: A man in a blue shirt sits at a desk and smiles at the camera; Copyright: University of Oslo

University of Oslo

Resistances: these bacteria hide and then take charge

23/11/2022

A doctor discovers bacteria in a sample that is causing a case of pneumonia and prescribes antibiotics. But at the same time, there is another, nastier variant of bacteria lurking in the patient’s body that is very glad to have got rid of its competitor.
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Image: A small square apparatus, an electrochemical sensing platform for studying in vitro vascular systems. The channels and reservoirs were visualized using blue ink.; Copyright: Tohoku University

Tohoku University

Sensing platform for studying in vitro vascular systems

11/11/2022

The costliness of drug development and the limitations of studying physiological processes in the lab are two separate scientific issues that may share the same solution.
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Image: A shell made of polymers houses a photoresponsive molecule, which is irradiated with UV light and creates an opening; Copyright: MPI-P

MPI-P

How light can be used to control processes in synthetic cells

12/10/2022

Synthetic – i. e. artificially produced - cells can imitate certain functions of biological cells. These synthetic cells could open up new medical possibilities in the future.
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Image: Close-up of an IV drip with a man in white scrubs in the background; Copyright: Anna Schroll/UKJ

Anna Schroll/UKJ

Therapeutic drug monitoring of antibiotics in sepsis

19/09/2022

The Target trial of Jena University Hospital tested the effect of therapeutic drug monitoring for antibiotics in patients with sepsis.
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Image: Electron microscopic image of Mycobacterium tuberculosis; Copyright: 4.0/Finci, I. et al.

4.0/Finci, I. et al.

Personalised antibiotic treatment strategies for tuberculosis patients

16/09/2022

In an international study presented in the journal Lancet Microbe, DZIF researchers have now succeeded in identifying patient-specific resistance patterns using a bacterial genome analysis technique.
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Image: A photo in a dark room with weak green light shows a novel biohybrid sensor technology; Copyright: Fraunhofer IPA

Fraunhofer IPA

Biointelligent sensor for measuring viral activity

16/09/2022

Fraunhofer IPA is the overall coordinator of the European biointelligence project BioProS, which is funded with over 6 million euros as part of the HORIZON Europe programme. In this project, a biointelligent sensor for measuring viral activity for the production of therapeutics is being developed.
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Image: Image of the inside of a blood vessel; Copyright: DZNE/LAT

DZNE/LAT

Drug testing with artificial brain vessels

09/09/2022

In Biomaterials, DZNE researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases. This analytical technique allows to study in the laboratory whether new drug candidates have a realistic chance of reaching the brain.
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Bild: Attached ECG electrodes to a male patient; Copyright: nunezimage

nunezimage

Attaining sinus rhythm mediates improved outcomes with atrial fibrillation

07/09/2022

A mediator analysis of the EAST – AFNET 4 trial dataset revealed the key factor for the effectiveness of early rhythm control (ERC) in patients with atrial fibrillation (AF): The presence of sinus rhythm at 12 months after randomization explains 81% of the outcome-reducing effect of ERC.
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Image: Flags are blowing in the wind to the backdrop of a dark evening sky; Copyright: Messe Düsseldorf/ctillmann

Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04/11/2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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Image: Two petri dishes with different kinds of agar plates on which bacterial cultures are growing; Copyright: panthermedia.net/photographee.eu

Antibiotic resistance: technical tricks against pathogens

01/08/2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: panthermedia.net/Arne Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"

01/08/2019

Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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Image: A greenly lit laboratory device; Copyright: Sven Döring

Photonics: "We want a rapid and easy method to identify pathogens and antibiotic resistance"

01/08/2019

The medical devices value chain has gaps between academic research and industrial practice that slow down innovation processes. This also applies to time-sensitive and urgently needed products such as rapid diagnostic tests to identify resistant pathogens. At the InfectoGnostics Research Campus in Jena, partners from research and medicine team up to close these gaps.
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Image: A man is holding a hand full of pill blisters with antibiotics; Copyright: panthermedia.net/alexkalina

Combating antibiotic resistance: One step ahead through technology

01/08/2019

Antibiotic resistance is on the rise in all parts of the world, complicating medical treatment of serious bacterial infections in patients. The World Health Organization estimates that approximately 33,000 people die each year from antibiotic-resistant bacteria in Europe alone. Bacteria that are resistant to multiple or even all known antibiotics pose an ever-increasing threat.
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Image: senior coughing man with cigarette; Copyright: panthermedia.net/ljsphotography

All-round care for COPD: diagnosis, treatment, self-management

01/03/2019

COPD affects more than 200 million people in the world. Those affected by this chronic pulmonary disease are often slow to notice the symptoms and get a medical diagnosis. This results in secondary complications and high medical costs. That's why an early diagnosis, comprehensive treatment, and frequent monitoring are very important. Various devices and tools support this all-round care.
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Image: Dosage inhaler and stethoscope in front of a shelf; Copyright: panthermedia.net/liudmilachernetska@gmail.com

React early, breathe free – comprehensive COPD management

01/03/2019

COPD is considered the third most common cause of death worldwide and mainly affects smokers. It is not curable, but with the right combination of early diagnosis, therapy and self-management, a significant part of the quality of life can be regained. The comprehensive care is supported by various devices and technical tools. Learn more about the all-round care of COPD in our Topic of the Month.
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Image: Preemie doll with drug delivery system on the nose; Copyright: Fraunhofer ITEM/Till Holland

Fraunhofer ITEM/Till Holland

Gentle medication for the little ones – with every breath

22/02/2019

According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
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