Brain volume and memory impairment: conventional vs ultrafast 3D MRI sequences

To compare automated brain volume measurements between conventional 3D T1W and ultrafast 3D echo-planar imaging (EPI) T1W sequences, Baek and colleagues retrospectively studied 36 patients (25 women, 11 men; mean age, 68 years) with memory impairment who underwent 3-T brain MRI. Examinations included both isotropic 3D T1W using inversion recovery gradient-recalled echo sequence (slice, 1.0 mm; acquisition, 3:04) and, in patients exhibiting motion, isotropic 3D EPI T1W sequence (slice, 1.2 mm; acquisition, 0:30). Using NeuroQuant (CorTechs Labs) and FreeSurfer (Harvard University) software to automate brain segmentation, measurements were compared between sequences for nine regions in each hemisphere.

For automated brain volumetry from ultrafast 3D EPI T1W imaging, compared with conventional 3D T1W imaging, most regions demonstrated at least substantial agreement between the two sequences—yet also significantly different mean values, moderate or large effect sizes, and consistent systematic biases with wide limits of agreement.

"The variation between the two sequences was observed in subset analyses of 16 patients with, and 20 patients without, Alzheimer disease," the authors of this AJR article added.

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