In the EU "AIDPATH" project, the partners from industry and research will build an automated and intelligent facility over a period of four years that is capable of producing targeted and patient-specific cell therapy directly at the point of treatment. In addition, the project addresses the integration of the facility into the hospital environment, taking into account logistics processes as well as data management and data security.
The fairly new CAR-T cell therapy is based on genetically modified T cells. These are the body's own white blood cells that make up part of the immune system. The T cells are taken from the patient's blood for treatment and equipped with a so-called chimeric antigen receptor (CAR). This receptor enables the cells to recognize and destroy tumor cells. CAR-T cell therapy has already been used in Germany for two years and is paving the way for completely new treatment approaches in hematology and oncology. However, much of the time spent on CAR-T cell therapy to date has still been taken up by complex logistics processes from central production facilities and inflexible manufacturing and application schemes. In addition, it has not yet been possible to take into account the individual cell characteristics of the patient, so that the success of the therapy cannot always be guaranteed.
For a patient-tailored therapy with CAR-T cells, the partners in the EU "AIDPATH" project are relying on artificial intelligence (AI) that incorporates the patient's individual data and biomarkers into the therapy process. This should produce highly potent and optimally adapted CAR-T cell products that target the altered cells in the patient's blood or the tumor. AI technology is also being used to control upstream and downstream production and logistics processes to improve scheduling and resource planning. A key benefit of automated, decentralized production is the potential to shorten production times and make therapy available to patients sooner. Alongside this, costs and utilization of hospital resources can be reduced. Overall, this results in improved access for patients to this form of therapy.
In the EU "AIDPATH" research project, we are creating a prototype for the intelligent and automated production of therapeutics of the future. The hospital environment is integrated in an intelligent way and aspects of logistics, capacity planning, data management and IT security are also included. CAR T-cell manufacturing will take place in a compact facility that can be operated by medical professionals on-site at the hospital. This enables personalized treatments to be delivered directly at the point of care. In this way, we are enabling a paradigm shift in the care of patients with personalized therapeutics", says Niels König, head of the department production metrology at the Fraunhofer IPT, who is coordinating the project.
MEDICA.com; Source: Fraunhofer Institute for Production Technology IPT
