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The effects of 3 weeks of rTMS treatment on P200 amplitude inpatients with depression

TMS Treatment for Depression


# TMS: Clinial Paper (Published at an SCI journal) on Sept 2014

Previous studies have reported that repetitive transcranial magnetic stimulation (rTMS) induces neuronalplasticity in the brain. Although event-related potential (ERP) is an exploration tool, the rTMS effects onERPs in patients with major depression have not been fully explored. We demonstrated that rTMS treat-ment induces changes in brain function in patients with medication-resistant major depression usingthe ERP. Eighteen patients with medication-resistant major depression (five males and 13 females) par-ticipated in this study. The patients received rTMS treatment for 3 weeks. All patients completed clinicalscales, including the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Scale (HAM-A), BeckDepression Inventory (BDI), State-Trait Anxiety Inventory (SAI, TAI), Ruminative Response Scale, Emo-tion Regulation Questionnaire, and Cognitive Emotion Regulation Questionnaire (CERQ), as well as theERP auditory oddball task, at their first visit (baseline) and at the 3-week visit (3-weeks). The HAM-D,HAM-A, BDI, SAI, and “blaming others” scale of the CERQ decreased significantly after rTMS treatment. InERP auditory oddball task, when FP1, FP2, FZ, FCZ, CZ, and PZ channels were analyzed, P200 amplitudesshowed a main effect for time of measurement and increased after 3 weeks of rTMS treatment. Standard-ized low-resolution brain electromagnetic tomography showed significant activation in the left middlefrontal gyrus by 3 weeks of rTMS treatment. The results suggest that relatively longer rTMS treatmentinduces changes in brain function in patients with medication-resistant major depression, which can beidentified using ERP.© 2014 Elsevier Ireland Ltd. All rights reserved