Separate Methods for Handling Evidence Neither Identifiable Nor Required -- MEDICA - World Forum for Medicine

The German Federal Ministry of Health therefore commissioned the Institute for Quality and Efficiency in Health Care (IQWiG) to answer the following question: What methodological approaches are used by guideline developers and health technology assessment (HTA) agencies in the handling of evidence (clinical study results) for the development of guidelines on rare diseases? In addition, IQWiG was to investigate whether physicians and researchers pose different requirements for the evidence in guidelines on rare diseases than for guidelines on other, more common diseases.

For this purpose, IQWiG systematically searched for and evaluated manuals on the development of treatment guidelines, methods papers by important HTA agencies, as well as guidelines on selected rare diseases. The findings show that the handling of evidence on rare diseases is hardly addressed in these documents. Explicit references to or instructions on the handling of such evidence was found only sporadically; in any case, uniform methodological requirements cannot be inferred from the information retrieved.

However, neither do the manuals, methods papers, and guidelines analysed provide indications that a fundamentally different approach and different requirements should be adopted for rare diseases than for more common ones.

"Little or no evidence is not only a problem of rare diseases,” explains IQWiG's Director Jürgen Windeler. "It is still possible to develop guidelines, and in principle there is no good reason to adopt a different approach or pose different requirements for rare diseases than for more common ones. This applies to the handling of evidence (as investigated in the report) as well as to the planning and conduct of the clinical studies themselves. If people with rare diseases are to be provided with high-quality health care, then studies of high methodological quality are required. The number of patients affected is usually large enough to enable such studies - even if in some cases international cooperation is needed.”

The Federal Ministry of Health commissioned IQWiG in August 2010. The report was to be prepared in an accelerated procedure as a "rapid report”. In contrast to the usual procedure, no preliminary reports are published here. Although a preliminary version of the rapid report is reviewed externally, no hearing is conducted in which all interested parties can submit comments. The report was prepared in collaboration with external experts and sent to the contracting agency at the end of March 2011.; Source: IQWiG - Institute for Quality and Efficiency in Health Care