Pharmacogenetic Tests for Personalised Medicine -- MEDICA - World Forum for Medicine


Astra Biotech GmbH

Pharmacogenetic Tests for Personalised Medicine

Personalised medicine is based on the concept that genetic characteristics of each person define his or her predisposition to develop certain diseases, determine the course of disease, and contribute to individual response to medical treatment.

Normally, the patient receives a drug in which the dose is generally determined according to the patient’s age, gender and weight. The same dosage, however, can be more or less effective in different patients due to their genetic traits.

Metabolising enzymes include cytochrome CYP2C9, CYP2C19 and CYP2D6 that are encoded by highly polymorphic genes. Astra Biotech’s pharmacogenetic tests permit evaluation of genetically-determined sensitivity to certain groups of drugs, such as oral anticoagulants, antidepressants, neuroleptic and psychotropic drugs, beta-blockers and proton pump inhibitors, among others. Polymorphism detection in genes associated with drug metabolism is carried out using real-time PCR. The tests are designed for simultaneous detection of most common mutations in these genes which are linked with enzyme activity alterations.

Another Astra Biotech assay detects a widespread mutation in the VKORC1 gene, which encodes the subunit of vitamin K epoxide reductase complex, a target for oral anticoagulants. The polymorphism in this gene defines the strength of the protein expression, which results in an increase or decrease of the required dosage of anticoagulants allowing better treatment.
Pharmacogenetic tests provide important information about individual genotypes which subsequently facilitate adjustment of the medication for each patient. This improves therapeutic efficacy and reduces side effects.

Astra Biotech’s kits include all necessary components and can be combined with any extraction method and a variety of PCR instruments. They are based on high quality raw materials and strict quality control procedures in compliance with IVD criteria.
Astra Biotech’s portfolio includes other products for genetic diagnostics, including those which determine an individual’s risk of thrombosis, and products for DNA extraction.

For information contact:
Dr. Christiane Stoll
Astra Biotech GmbH
Tel: +49 3371681450

About Astra Biotech GmbH
Astra Biotech GmbH is a quality-focused company based on dependable science and strong customer relationships. The range of products available includes high quality reagents, allergens, antibodies, recombinant proteins, slides for microarrays, as well as assays for the determination of human hormones, allergies, tumour markers and genetic diseases.

Astra Biotech aims to optimise patient healthcare by offering laboratories, hospitals and diagnostic centres excellent quality, affordable reagents and assays which meet and exceed the standards set by leading international laboratories.