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Image: Cryo-electron microscope images; Copyright: Sanford Burnham Prebys Medical Discovery Institute (SBP)

Powerful microscope revolutionizes cell insights

14/01/2019

There are many times when our cells need to move. Mobile cells guide our body's formation (embryonic development). Immune cells roam to capture unwanted intruders. And healing cells (fibroblasts) migrate to mend wounds. But not all movement is desirable: Tumors are most dangerous when cancer cells gain the ability to travel throughout the body (metastasis).
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Image: 3D-printed absorber for endovascular treatment of liver cancer; Copyright: UCSF graphic

Drug sponge could minimize side effects of cancer treatment

11/01/2019

With the help of sponges inserted in the bloodstream to absorb excess drugs, doctors are hoping to prevent the dangerous side effects of toxic chemotherapy agents or even deliver higher doses to knock back tumors, like liver cancer, that don't respond to more benign treatments.
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Image: esophageal tumors; Copyright: panthermedia.net / sciencepics

Mapping residual esophageal tumors - a glimpse into the future?

10/01/2019

It's one of the first questions asked by many cancer patients "What are my chances of beating this?" Often there is no clear answer, with survival rates differing widely. Post-operative testing that provides an accurate prediction of long-term treatment outcomes is the next best thing, allowing clinicians to plan further treatment and more accurately inform patients about their prognoses.
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Image: The Digital Precision Cancer Medicine Platform; Copyright: University of Helsinki

Digital health to support precision cancer medicine in iCAN

09/01/2019

The Academy of Finland has selected the "iCAN Digital Precision Cancer Medicine" competence cluster as one of Finland's six flagships. The iCAN public-private partnership forms a platform aiming to improve the treatment of cancer patients and to support innovations coming from high quality research.
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Image: Philip Miller with the new microneedle technique; Copyright: Randy Montoya, Sandia National Laboratories

Microneedles technique for quicker diagnoses of major illnesses

08/01/2019

When people are in the early stages of an undiagnosed disease, immediate tests that lead to treatment are the best first steps. But a blood draw - usually performed by a medical professional armed with an uncomfortably large needle - might not be quickest, least painful or most effective method, according to new research.
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Image: breath test for multiple cancers; Copyright: Owlstone Medical Ltd

Clinical trial launches to develop breath test for multiple cancers

07/01/2019

Researchers have launched a clinical trial to develop a breath test, analysing molecules that could indicate the presence of cancer at an early stage. This is the first test of its kind to investigate multiple cancer types.
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Image: A tumor cell lights up with high FRET biosensor readout; Copyright: UC San Diego Health

Sensors to detect and measure cancer's ability to spread

02/01/2019

The spread of invasive cancer cells from a tumor's original site to distant parts of the body is known as metastasis. It is the leading cause of death in people with cancer. In a paper published online in iScience, University of California San Diego School of Medicine researchers reported engineering sensors that can detect and measure the metastatic potential of single cancer cells.
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Image: A doctor looks at a x-ray.; Copyright: panthermedia.net/minvervastock

Higher radiation dose increases cancer risk

21/12/2018

Extremely obese people are needing a far higher dose of radiation during x-ray examinations than people of normal weight, increasing their risk of cancer, new research has shown.
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Image: nonlinear imaging of the tumor microenvironment; Copyright: Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

Novel imaging technique brings diagnostic potential into operating room

21/12/2018

A team of University of Illinois at Urbana-Champaign researchers led by Professor Stephen Boppart has successfully visualized the tumor microenvironment of human breast tissue shortly after it was surgically removed from a patient in the operating room. The researchers achieved this using a new portable optical imaging system developed in Boppart's lab.
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Image: patient and doctor during mammography; Copyright: panthermedia.net / luminastock

Digital mammography increases breast cancer detection

12/12/2018

The shift from film to digital mammography increased the detection of breast cancer by 14 percent overall in the United Kingdom without increasing the recall rate, according to a major new study.
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Image: New deformable particle model; Copyright: Mark Shattuck, CCNY

Shape shifting cell breakthrough

12/12/2018

A new computational model developed by researchers from The City College of New York and Yale gives a clearer picture of the structure and mechanics of soft, shape-changing cells that could provide a better understanding of cancerous tumor growth, wound healing, and embryonic development.
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Image: microscopic images of cancer cells; Copyright: panthermedia.net / raspirator

Cancer cells distinguished by artificial intelligence-based system

11/12/2018

Osaka University researchers have developed a system using artificial intelligence that can automatically differentiate between different types of cancer cell.
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Image: The MPI team: Noelia Díaz, Kai Kruse and Juanma Vaquerizas; Copyright: MPI Münster

Nuclear architecture diagnostics within reach of the clinic

07/12/2018

Scientists at the Max Planck Institute of Molecular Biomedicine in Münster and of the Medical Faculty of the University of Münster have developed a technique that allows the characterisation of the three-dimensional organisation of the DNA in the nucleus directly in patient's cells.
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Image: smartphone with healthcare app; Copyright: Houston Methodist

App helps breast cancer survivors

03/12/2018

Breast cancer survivors who used a smartphone app created at Houston Methodist consistently lost weight, largely due to daily, real-time interactions with their health care team via the mobile app. Few clinically-tested mobile apps exist today with clear measurable goals to support continued care of cancer survivors and patients.
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Image: MRI post ablation; Copyright: Radiological Society of North America

Cryoablation shows promise in treating low-risk breast cancers

29/11/2018

Cryoablation-the destruction of cancer cells through freezing-shows early indications of effectiveness in treating women with low-risk breast cancers, according to research being presented today at the annual meeting of the Radiological Society of North America (RSNA). Researchers said that over the four years of the study, there has only been one case of cancer recurrence out of 180 patients.
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Image: Darmkrebs; Copyright: panthermedia.net / Sebastian Kaulitzki

Screening for colorectal cancer spares intense treatments

26/11/2018

Colorectal cancer is the third most common form of cancer in the world. Every year in Finland, approximately 3,000 new cases are diagnosed, and roughly 1,200 patients die of it. Between 2004 and 2016, an extensive screening programme was conducted in Finland, intending to study the potential benefits and downsides of a nation-wide screening for colorectal cancer.
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Image: Doctor on a computer display examines RNA-sequences; Copyright: panthermedia.net / Lev Dolgachov

New technique improves single cell RNA sequencing

26/11/2018

In the era of personalized medicine, scientists are using new genetic and genomic insights to help them determine the best treatment for a given patient. In the case of cancer, the first step toward these treatments is an investigation into how tumor cells behave in an effort to figure out the best drugs to use to attack them.
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Image: two doctors watching on a computer monitor; Copyright: panthermedia.net/Lev Dolgachov

Computer classifies breast cancer tumors

20/11/2018

Using technology similar to the type that powers facial and speech recognition on a smartphone, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have trained a computer to analyze breast cancer images and then classify the tumors with high accuracy.
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Image: polyol-modified nanoparticles checking out blood vessels surrounding the tumors; Copyright: Yoon Yeo/Purdue University

Cancer identity technology makes it easier to find tumor's "address"

16/11/2018

Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right "address" in the body while also easing the painful side effects of chemotherapy on patients. One of the big issues with chemotherapy is that most treatment approaches focus on the tumor itself without paying attention to the microenvironment surrounding the tumor.
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Image: Prostata under microscope; Copyright: panthermedia.net / Martin Kreutz

Prostate cancer radiotherapy can be more precisely targeted

09/11/2018

Current standard imaging techniques for initial staging of prostate cancer often underestimate the extent of disease beyond the prostate. A study featured in The Journal of Nuclear Medicine's November issue demonstrates that prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) can pinpoint prostate cancer locations with superior accuracy.
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Image: fluorescent marker in use; Copyright: Colin Watts

New fluorescent marker

05/11/2018

A chemical that highlights tumour cells has been used by surgeons to help spot and safely remove brain cancer in a trial presented at the 2018 NCRI Cancer Conference.
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Image: Brain; Copyright: panthermedia.net / Wavebreakmedia Itd.

Brain infection or cancer? A new rapid test could hold the answer

02/11/2018

When patients present with neurologic symptoms such as severe headaches or seizures, the symptoms could suggest anything from infection, cancer, or an autoimmune disease of the brain or spinal cord. The differences in diagnosis can mean having mere hours to act. Researchers at Jefferson have developed a test that could rapidly parse out infections of the brain from other diseases.
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Image: Dr. Ravindra Kohle and Augusta OncoTarget; Copyright: Phil Jones / Augusta University

MCG lab designated to help with patient testing for NCI-MATCH trial

02/11/2018

The Georgia Esoteric and Molecular Laboratory at the Medical College of Georgia at Augusta University has been selected as a designated laboratory for the National Cancer Institute's Molecular Analysis for Therapy Choice, or MATCH trial, which is assessing the effectiveness of targeting cancer-causing gene changes rather than cancer type.
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Image: visitors at MEDICA; Copyright: Messe Düsseldorf

See, experience, learn: what's new at MEDICA 2018

02/11/2018

It's time: the world's largest medical trade fair opens its doors from 12 to 15 November. More than 5,000 international exhibitors will present their new innovative products and applications. Frums, conferences and special shows will feature exciting specialist lectures and discussions that will give you an insight into electromedicine, laboratory medicine, medical technology and diagnostics.
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Image: Raman microscopy to develop better cancer drugs; Copyright: panthermedia.net / Alex011973

Testing cells for cancer drug resistance

30/10/2018

Biophysicists at Ruhr-Universität Bochum (RUB) have demonstrated that Raman microscopy can be used to detect the resistance of tumour cells to cancer drugs. Unlike conventional approaches, this method does not require any antibodies or markers. It detects the response of cells to administered drugs and therefore could determine the effect of drugs in preclinical studies.
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Image: Antibody against tumor cells; Copyright: panthermedia.net / toeytoey

Novel method to block immunosuppression in cancer

29/10/2018

Belgian research groups from the UCLouvain and WELBIO, VIB and Ghent University, and the biotechnology company argenx elucidated the three-dimensional structure of an assembly of proteins that dampen immune responses. They also discovered how an antibody can block this assembly. Such an antibody could serve to stimulate immunity against tumor cells in cancer patients.
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Image: diagnosis of the lung; Copyright: panthermedia.net/Sergey Nivens

With modern imaging supplies: A look into the lung

01/10/2018

Thanks to various imaging supplies, it is possible to make the inside of the body accessible for diagnostics, research and treatment. The lung, one of the most important human organs for survival, is also examined in this way. In our Topic of the Month, we looked at how doctors are getting a closer look at the lung, how the procedures differ, and which ones will be available in the near future.
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Image: Small brown mole on the back of a hand; Copyright: panthermedia.net/Mario Hahn

Early detection: Tattoo signals cancer – and more

09/07/2018

People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
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Image: DermaFC developed by Magnosco; Copyright: Magnosco

A startup makes melanin glow: skin cancer diagnostics with Magnosco

09/04/2018

When a skin lesion is suspected to exhibit malignant changes, it is usually promptly removed. However, not all cases require an excision of the affected tissue. The startup company Magnosco has developed a procedure that uses a laser to support the diagnosis and early detection of malignant melanoma.
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Image: Man with stethoscope and medical symbols; Copyright: panthermedia.net/everythingposs

Between austerity measures and growth pressure - Latin America's medical market

03/04/2018

A region whose states make up the world's third largest economy and which has few linguistic differences - Latin America is an attractive market for foreign companies at first glance. This also applies to the medical market. However, various factors are contributing to the fact that this market is growing only slowly in most countries.
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Image: A group of physicians is holding large colorful puzzle pieces in their hands and is putting them together; Copyright: panthermedia.net/Andriy Popov

Personalized medicine: a paradigm shift is gaining momentum

01/03/2018

Personalized medicine does not follow a "one-size-fits-all" treatment approach but emphasizes a "tailor-made" paradigm, meaning a treatment is customized to each individual person's case. For patients, this increases the chances of treatment success and means fewer side effects. While the approach originates in the field of oncology, it is now also increasingly applied to other disease patterns.
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Image: Three men in suits and a woman in a laboratory coat are standing in a laboratory; Copyright: Ministry of Economy of Mecklenburg-Hither Pomerania/Norbert Fellechner

On the trail of cancer: personalized cancer vaccine

01/03/2018

Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01/03/2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research

22/02/2018

Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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Image: Vials in a rack; Copyright: Messe Düsseldorf

MEDICA 2017: all about laboratory medicine at the MEDICA LABMED FORUM

02/10/2017

If you are interested in laboratory medicine and come to the MEDICA 2017, you will quickly notice that Exhibition Halls 1 and 2 were demolished. A new state-of-the art hall is meant to take their place. Until then, exhibitors from the field of laboratory medicine will be showcased at their temporary new location in the lightweight hall structures 3a and 18 on the fairgrounds.
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Image: Colored sonographic image of the human heart from Doppler ultrasonography; Copyright: panthermedia.net/Belish

Imaging techniques: ultrasound, MRI, CT, catheters and other procedures to keep a healthy heart

01/09/2017

Many people are affected by heart disease today because - among other reasons- our modern unhealthy lifestyle is taking a toll on our hearts. A reliable diagnosis and treatment are crucial for patients with heart disease since all other organs depend on the pumping of our vital organ. Modern imaging techniques are a key to understanding the heart.
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Image: interferometric detection of scattered light, iSCAT; Copyright: MPL

Interface between Physics and Medicine: new interdisciplinary center

22/08/2017

Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
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Image: A large medical device with a treatment couch and four movable boxes; Copyright: panthermedia.net/Thomas Hecker

Cancer: refined treatment with proton minibeams

10/07/2017

Radiation therapies are an essential component of today’s oncology because they enable the treatment of localized tumors. Yet they have one major drawback: radiation damages not just tumor cells but also healthy tissue. One solution to solve this problem could be proton minibeam therapy, which uses finely focused beams.
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Image: A flat device with a touch screen; Copyright: biolitec AG

Surgical lasers: the quest to be compact, mobile, and user-friendly

03/07/2017

Not all lasers are the same – especially in the surgical field, it all depends on what’s inside: the different operational wavelengths of laser light also affect human tissue in different ways. This is why a single laser for a variety of applications drastically simplifies the job of physicians.
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Image: A dermatology laser is used to remove a mole; Copyright: panthermedia.net/Michael Krause

Laser surgery: usability, flexibility, treatment quality

03/07/2017

The scalpel is considered the classic surgical instrument and as such, has remained unchanged for quite some time. However, today’s technology opens up a world of new possibilities for cutting tissue. Next to high-frequency electrosurgical scalpels that work with electric power, surgeons also use a variety of different lasers. They promise great usability and better treatment.
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Image: A women with a bald head and a headscarf, smiling, sitting on a sofa talking ot another woman; Copyright:Katharina Bia asiewic

Irreversible Electroporation – Last hope for liver cancer patients

24/04/2017

Liver cancer is the fifth most common malignant tumor in the world. The tumor can be removed through surgery or by utilizing thermal ablation techniques. If a treatment with conservative methods is no longer possible, there is an alternative: irreversible electroporation (IRE). The effectiveness of this method was now confirmed by a clinical study.
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Image: A young girl is lying in the hospital bed, behind her a nurse is adjusting a monitor; Copyright: panthermedia.net / Monkeybusiness Images

Working with children with cancer – More than just a job

02/01/2017

Our topic title "pediatric (children’s) oncology" evoked strong emotional reactions from several mothers and fathers of our staff. "This hits too close to home for me, I couldn’t write about it", or "How do people manage to deal with this?". And we are only on the sidelines; physicians, caregivers and nurses at the hospital, hospice or families at home are the ones that have the real tough job.
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Image: Three physicians during a meeting; Copyright: KiTZ/Philipp Benjamin

Children's Tumor Center: consolidated treatment under one roof

02/01/2017

Treatments for children need to be different from treatment for adults – this also applies in oncology. Having said that, children do not just need new and different treatment concepts that still necessitate research. They also require the support from their families, who need to be nearby during treatment.
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Photo: Old woman with a smartphone

Health Apps: "Mobile Applications for smartphones have strengths and weaknesses"

22/03/2016

Medical apps like diabetes or high blood pressure diaries are becoming increasingly popular with smartphone users. There are many available choices out there but they are not always clear. Added to this is the question of how the data collected by the apps can be sensibly incorporated into treatment.
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Graphic: The pancreas and the surrounding organs

Pancreatic cancer: diagnosis via signature analysis

08/03/2016

Pancreatic cancer is one of the deadliest forms of cancer because it is difficult to diagnose and only presents with symptoms in the later stages. In the future, a laboratory test developed at the Greifswald University Medicine could make an early detection of this type of cancer and consequently a faster and better treatment possible.
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From the periodic table of elements into medicine: silicon for theranostics

01/10/2015

Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
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Theranostics: Complex particles for tomorrow's medicine

01/10/2015

It is a portmanteau, a mixture of two words. This way it saves us time and trouble while speaking because the human speech apparatus is lazy. And it describes a mixture of procedures: the combination of two procedures that would normally be separate in medicine. We are talking about theranostics.
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Fighting myomas with ultrasound

01/10/2015

A proper diagnosis is a part of great therapy. However, it can also be beneficial to be able to quickly respond to changes during a treatment. One example of this is the treatment of uterine myomas. Female patients at the University Hospital Bonn are treated using so-called high-intensity focused ultrasound, HIFU in short. Prof. Holger Strunk explains this procedure.
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Prostate cancer: Agent with theranostic potential

03/08/2015

Endoradiotherapy can be very unpleasant for cancer patients, since it does not only harm tumor cells, but also healthy ones. Sometimes, patients even need to stop therapy because of the side effects. Physicians and researchers are thus continuously searching for ways to transport radiopharmaceuticals directly and exclusively to their target.
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Lung cancer: A blood test evaluates the effectiveness of therapy

01/06/2015

Can liquid biopsies become the new trend in cancer diagnostics? The medical world has asked this question for quite some time. The first globally approved liquid biopsy-based test for lung cancer shows that this can work. Yet further findings and research are still required to establish this less invasive method in diagnostics.
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Cancer Immunotherapy: Individual mutations as new target structures

01/06/2015

A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
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Tumor markers: State-of-the-art diagnostics for personalized medicine

01/06/2015

When cancer is diagnosed, the terms tumor markers or biomarkers keep popping up. They describe characteristics that are not found in healthy persons. The classic tumor markers can be easily detected in blood samples or other body fluids. Other analysis methods require more effort. Yet they all share one thing in common: biomarkers indicate a potential tumor.
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Early cancer detection: "Physicians and patients need a good database"

04/05/2015

Whether it is a mammogram, colonoscopy or a skin cancer screening – after a certain age, we are subject to various early cancer detection screenings. Yet many of us don’t know that these screening tests are also associated with risks. This is something what Dr. Sylvia Sänger from the University Medical Center Hamburg-Eppendorf discovered in a study.
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Statutory Skin Cancer Screening: "This is not just about mortality rates"

04/05/2015

Since the end of April 2015, the long-awaited evaluation report on the skin cancer screening programs offered by German health insurance providers is now finally available. We spoke with Dr. Ralph von Kiedrowski, Board Member of the German Dermatologist Association (German: Berufsverband Deutscher Dermatologen) on what the screening can accomplish and his take on the G-BA report.
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Cancer prevention: Beneficial and ultimately personal

04/05/2015

There are many decisions to be made in an adult life; among them are cancer prevention screenings. They are voluntary and many people deliberate whether they should go or not and if they would actually want to know the results. Science, politics and health care professionals also ponder with each new preventive service whether it is beneficial and who should end up paying for it.
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Photo: Object slides

Tissue storage: "Our top biobanks are internationally leading the charge"

02/02/2015

Only projects with a solid foundation are successful in the long run. This is also true for science. Biobanks are the most important component of this foundation when it comes to fundamental biomedical research: Only high quality tissue samples that are stored there make conclusive research possible - for example in search of the causes of tumorigenesis.
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Xenon magnetic resonance imaging: making pathological changes in the body visible

03/11/2014

As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
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Surgery: "Our camera detects the tiniest remainder of a tumor"

03/02/2014

Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
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KOHALA: digital student for cancer treatment

03/02/2014

Shortening a time-consuming procedure from four hours to five minutes and automate it at the same time sounds like a dream come true for employees in all fields and industry sectors. This dream could soon become a reality for radiologists. Software could take away the tedious processing of CT images, which is required before cancer radiation therapy.
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Radiology and technology: "Numerous phantom studies have been conducted that prove the advantages of this new CT system"

03/02/2014

Radiologists usually do their work after oncologists when it comes to cancer treatment. Yet modern radiology also provides treatments at this point. MEDICA.de spoke with Professor Stefan Schönberg, Director of the Institute of Clinical Radiology and Nuclear Medicine at the University Medical Center Mannheim, Germany, about the use of a new computer tomograph and its benefits for patients.
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Photo: Removal of a colon polyp with a snare

Endoscopy: "A small section of the colonic wall is completely removed"

05/01/2014

Eventually, all adults need to see a physician for colon cancer prevention. While the exam goes by quickly thanks to sedation, it sometimes leads to a follow-up procedure if a growth in the colon could not be removed with the endoscope and requires open surgery.
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