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Image: PAGA based embedding of the developmental trajectories in the Zebrafish embryo, colored by timepoint.; Copyright: Wagner et al., Science (2018)

Clear sight in the data fog with PAGA

16/04/2019

Experimental molecular assays with single-cell resolution generate big and complex data. Researchers at Helmholtz Zentrum München and the Technical University of Munich are now presenting their computer algorithm PAGA.
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Image: Visualization on sample whole-slide images of the lung cancer histologic patterns; Copyright: Hassanpour Lab, Dartmouth's Norris Cotton Cancer Center

New machine learning model classifies lung cancer

06/03/2019

Using recent advances in machine learning, a Dartmouth research team has developed a deep neural network to classify different types of a common form of lung cancer on histopathology slides at an accuracy level shown to be on par with pathologists.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Healthy mucus layer (red) keeping Escherichia coli (green) at a safe distance within the colon, preventing them from breaking throug; Copyright: Bahtiyar Yilmaz, University of Bern

Discovery of bacterial signature of intestinal disease

22/01/2019

Researchers from the Department of Biomedical Research of the University of Bern and the University Clinic of Visceral Surgery and Medicine of the Inselspital Bern, Switzerland, have discovered that changes in the composition of the intestinal bacteria in patients with chronic inflammatory bowel disease affect the severity of the disease and the success of therapy.
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Image: man holding his stomach; Copyright: panthermedia.net/ByLove

The cure is in the capsule: carbon monoxide to treat chronic inflammation

22/05/2018

This unusual ally can be extremely valuable in the fight against inflammation in the body: CO (carbon monoxide). As a therapeutic gas, it also promises relief for inflammatory gastrointestinal diseases. Having said that, it is difficult to transport the active ingredient to the exact desired location.
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Image: Three men in suits and a woman in a laboratory coat are standing in a laboratory; Copyright: Ministry of Economy of Mecklenburg-Hither Pomerania/Norbert Fellechner

On the trail of cancer: personalized cancer vaccine

01/03/2018

Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01/03/2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: Photograph of hands with hyperspectral imaging; Copyright: Diaspective Vision GmbH

Precision surgery thanks to informative hyperspectral imaging

08/02/2018

When body tissue is reconnected during a tumor operation in the gastrointestinal tract, surgeons need information about the current state of these so-called anastomoses. The new, non-invasive hyperspectral imaging technology now makes it possible to measure the crucial parameters during surgery and thereby increase surgical precision.
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