25/04/2019Like other biofluids, sweat contains a wealth of information about what's going on inside the body. However, collecting the fluid for analysis, usually by dripping or absorbing it from the skin's surface, can be time-consuming and messy.
24/04/2019A new computational approach has been developed to reduce variability in common research biomarker tests, a promising step in improving the ability of biomedical researchers and basic scientists to reproduce data and facilitate more consistent results across laboratories and long-term projects.
23/04/2019They are working in the background, but the things they do often decide about the right therapy or can even be life savers: labs and laboratory technology are probably the most important part of today’s medicine. This is why World Laboratory Day aims to draw attention to this "hidden" part of medicine.
19/04/2019In order to understand the brain, scientists must be able to see the brain--cell by cell, and moment by moment. However, because brains comprise billions of microscopic moving parts, faithfully recording their activity comes with many challenges.
18/04/2019Biotechnologists, physicists, and medical researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have developed technology for microscopic imaging in living organisms.
17/04/2019An international team of scientists has mapped a molecular complex that could aid in the development of better medications with fewer side effects for osteoporosis and cancer.
17/04/2019Lensless microscopy with X-rays, or coherent diffractive imaging, is a promising approach. It allows researchers to analyse complex three-dimensional structures, which frequently exist in nature, from a dynamic perspective.
16/04/2019Experimental molecular assays with single-cell resolution generate big and complex data. Researchers at Helmholtz Zentrum München and the Technical University of Munich are now presenting their computer algorithm PAGA.
16/04/2019Biomedical engineers at Duke University have developed an automated process that can trace the shapes of active neurons as accurately as human researchers can, but in a fraction of the time.
12/04/2019North Carolina State University researchers have developed a technique to improve the characteristics of engineered tissues by using ultrasound to align living cells during the biofabrication process.
09/04/2019A team of Colorado State University researchers has developed technology that can detect extremely small amounts of antibodies in a person's blood. Antibodies develop to infect cells or kill pathogens, essentially fighting off a bacteria or virus. The levels of antibodies in the blood can tell whether that person is sick.
05/04/2019Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.
03/04/2019From birth through to death, cells lead an eventful existence. Thanks to single-cell genomics, their destiny can be analyzed. But this method destroys the cell. In order to address this problem, researchers at the Helmholtz Zentrum München and the University of Massachusetts use pseudodynamics, a mathematical model that estimates developmental processes from single-cell time series observations.
01/04/2019A research team led by biophysical chemist Professor Edward Lemke has engineered a designer organelle in a living mammalian cell in a new complex biological translation process. The created membraneless organelle can build proteins from natural and synthetic amino acids carrying new functionalities.
01/04/2019High-resolution optical microscopy methods promise breakthroughs in materials science, biology, and medicine. Today, their possibilities basically reach those of scanning electron microscopy.
25/03/2019Researchers tracked and quantified the production of different kinds of blood cells and immune cells to understand how the body maintains a balanced supply.
20/03/2019Researchers from the University of British Columbia and McMaster University have developed what could be the bone implant material of the future: an airy, foamlike substance that can be injected into the body and provide scaffolding for the growth of new bone.
18/03/2019A new method to diagnose cancer cells inside lymph nodes could allow doctors to treat cancers before they spread around the body
15/03/2019The debilitating side effects of radiotherapy could soon be a thing of the past thanks to a breakthrough by University of South Australia (UniSA) and Harvard University researchers. UniSA biomedical engineer Professor Benjamin Thierry is leading an international study using organ-on-a-chip technology to develop 3D models to test the effects of different levels and types of radiation.
14/03/2019Both developing babies and elderly adults share a common characteristic: the many cells making up their bodies are always on the move. As we humans commute to work, cells migrate through the body to get their jobs done. Biologists have long struggled to quantify the movement and changing morphology of cells through time, but now, scientists have devised an elegant tool to do just that.
11/03/2019A University of Waterloo researcher has spearheaded the development of the first computational model of the human kidney. The new model will allow scientists to gain better insights into how new drugs that target the kidney, such as diabetes medication, may work.
11/03/2019The tsetse fly has wreaked devastation across large swaths of sub-Saharan Africa. About the size of a housefly, the insect transmits a parasite that can be lethal to both humans (sleeping sickness) and animals (nagana). A Columbia team is therefore pioneering a machine-learning based imaging and sorting solution that aims to drastically reduce Africa's tsetse population.
08/03/2019Near-infrared technology pinpoints fluorescent probes deep within living tissue; may be used to detect cancer earlier.
08/03/2019Brown University researchers have developed a new antibacterial coating for intravascular catheters that could one day help to prevent catheter-related bloodstream infections, the most common type of hospital-acquired infection.
07/03/2019Scientists from Utrecht University, University Medical Center Utrecht and Hubrecht Institute have successfully created kidney organoids from urine cells. This could lead to a wide range of new treatments that are less onerous for kidney patients.
05/03/2019A new ultrasensitive diagnostic device invented by researchers at the University of Kansas, The University of Kansas Cancer Center and KU Medical Center could allow doctors to detect cancer quickly from a droplet of blood or plasma, leading to timelier interventions and better outcomes for patients.
04/03/2019Princeton University researchers are gaining new insights into the causes and characteristics of diseases by harnessing machine learning to analyze molecular patterns across hundreds of diseases simultaneously.
26/02/2019The technology, developed by researchers at Imperial College London and The University of Hong Kong, can be used to measure hormones that affect fertility, sexual development and menstruation more quickly and cheaply than current methods.
25/02/2019An international research team led by Friedrich Schiller University in Jena has developed a highly sensitive cell model to study the complex effects – and side effects – of anti-inflammatory drugs, with the ultimate aim of preventing chronic inflammation.
18/02/2019Using a novel optogenetic tool, researchers have successfully controlled, reproduced and visualised serotonin receptor signals in neural cells.
15/02/2019Researchers have developed a new AI-driven platform that can analyse how pathogens infect our cells with the precision of a trained biologist. The platform, HRMAn ('Herman'), which stands for Host Response to Microbe Analysis, is open-source, easy-to-use and can be tailored for different pathogens including Salmonella enterica.
13/02/2019Atypical ductal hyperplasia (ADH) is a breast lesion associated with a four- to five-fold increase in the risk of breast cancer. ADH is primarily found using mammography and identified on core needle biopsy. Despite multiple passes of the lesion during biopsy, only portions of the lesions are sampled.
12/02/2019Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease.
12/02/2019A team of scientists led by researchers at the University of Georgia Center for Food Safety in Griffin has developed a machine-learning approach that could lead to quicker identification of the animal source of certain Salmonella outbreaks.
11/02/2019Around a glioblastoma, a very aggressive brain tumor, cells of the human immune system start helping the tumor instead of attacking it. To do research on what happens in the interaction of these cells, scientists of the University of Twente now created a 3D-bioprinted mini model of the brain.
11/02/2019Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy and computer simulations, they were able to show that DNA molecules behave like a chain of small coil springs.
08/02/2019Researchers at Rensselaer Polytechnic Institute who developed a blood test to help diagnose autism spectrum disorder have now successfully applied their distinctive big data-based approach to evaluating possible treatments.
08/02/2019Human tissues experience a variety of mechanical stimuli that can affect their ability to carry out their physiological functions, such as protecting organs from injury. The controlled application of such stimuli to living tissues in vivo and in vitro has now proven instrumental to studying the conditions that lead to disease.
07/02/201924,000 patients are diagnosed with brain tumors every year with the 5yr survival for high grade glioblastomas (GBM) only 5%, with median survival of 15 months. These poor statistics have remained static for 30 years due in part to a lack of preclinical models for testing new drugs.
07/02/2019X-rays provide unique insights into the interior of materials, tissues, and cells. Researchers at the Paul Scherrer Institute PSI have developed a new method that makes X-ray images even better: The resolution is higher and allows more precise inferences about the properties of materials.
06/02/2019A new transistor based on organic materials has been developed by scientists at Linköping University. It has the ability to learn, and is equipped with both short-term and long-term memory. The work is a major step on the way to creating technology that mimics the human brain.
05/02/2019Finding the right dose of medication by trial and error can be a painful experience for patients. Thanks to a new algorithm created by Adrien Coulet, lecturer at the Université de Lorraine and researcher in a joint Inria and Loria team, in collaboration with researchers from Stanford University, an innovative tool can predict in advance whether patients will need a lower dose of medication.
05/02/2019A new technique to study tissue samples in 3D has revealed that pancreatic cancers can start and grow in two distinct ways, solving a decades-old mystery of how tumours form. The new method could help researchers to get more information from tissue biopsies and may lead to improved treatments for pancreatic cancers. The technique was developed by scientists at the Francis Crick Institute.
04/02/2019To provide sufficient oxygen to tissues and organs within the body, blood vessels need to sprout new offshoots to form a widespread blood supply network, much like the trunk, branches, and twigs of a tree. However, the mechanisms by which this sprouting occurs, in both normal healthy conditions and in conditions like cancer, have remained unclear.
01/02/2019Heart muscle cells need exercise - even when they grow outside the human body. A new device designed by U of T Engineering researchers uses a rigorous training regimen to grow small amounts of cardiac tissue and measure how strongly it beats. The platform is ideal for testing the effects of potential drug molecules and could help bring personalized medicine closer to reality.
01/02/2019In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
01/02/2019The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
01/02/2019Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
31/01/2019Scientists have successfully constructed a three-dimensional human epidermis based on predictions made by their mathematical model of epidermal homeostasis, providing a new tool for basic research and drug development.
29/01/2019Researchers have developed a simple blood test that can detect when a newly transplanted lung is being rejected by a patient, even when no outward signs of the rejection are evident.
28/01/2019Some people use fidget spinners - flat, multi-lobed toys with a ball bearing at the center - to diffuse nervous energy or whirl away stress. Now, researchers have found a surprising use for the toys: separating blood plasma for diagnostic tests.
21/11/2018Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
15/11/2018Whether DNA testing, tissue analysis or blood tests – the secrets of life are unraveled in the laboratory. In order to master this challenge, all processes must first be optimized and automated. Which role HSE AG plays here, the Swiss company explains at MEDICA 2018.
15/11/2018A lot of answers in medicine are found in the laboratory. Correct analysis is key to find the right diagnosis and cure for the patient. We learn more about innovative analysis devices at the stand of ERBA Diagnostics at MEDICA 2018.
02/11/2018This is what diagnostic investigation normally looks like: a patient sample is collected, sent to the laboratory and analyzed. Once that's completed, the patient is told of the lab test result. But if the patient is a high-performance athlete and has to follow and stick to a rigid training schedule, he or she needs these results immediately. What makes this possible? Point-of-care testing!
10/09/2018About eight in ten Germans suffer from back pain during their lifetime. Too much or the wrong movements can also cause problems. "Ran Rücken", the interdisciplinary research project aims to determine the right minimum dose of exercise that proves effective. (Explanatory note: "Ran Rücken" can be loosely translated as "Target the Back")
22/08/2018Mix-ups, contamination and sample loss – most errors in pathology happen when specimen are received. Countless samples arrive daily at the laboratory, while the sample entry process is very monotonous. As a result, the work is inefficient. The start-up company inveox has now developed a system that automates the processes in the pathology laboratory, thus making them more efficient.
30/04/2018Medicine is getting more and more personalized. This is particularly interesting for oncology, since a cancer is as individual as the respective patient. When choosing a therapy, both the characteristics of the tumor and the personal characteristics of the patient must be considered. To see exactly what this looks like, we visited the diagnostics company TherapySelect, based in Heidelberg.
01/03/2018Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
01/03/2018Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
22/02/2018Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
01/02/2018During a visit to the hospital, patients naturally expect to receive comprehensive care. Not only does this include the proper treatment, but also a hospital bed and regular meals for example. Patients typically don't ask about the transport logistics this entails for the hospital.
08/01/2018Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
23/10/2017According to the WHO, 300 million people throughout the world are affected by lymphedema. This condition occurs when fluid that flows between cells is no longer transported back into the blood circulation and accumulates in the skin. Triggers can be surgeries, injuries or genetic defects for example. A new microscopy technique could now also indicate the causes.
18/10/2017Point-of-care testing is an integral part of medicine. It enables simple, automated testing that yields fast results. Hospitals have also started to increasingly use POCT diagnostic systems over the past few years. We are guests at the Greifswald University Hospital where patient-side rapid diagnostic tests have already been successfully integrated into daily hospital operations.
02/10/2017If you are interested in laboratory medicine and come to the MEDICA 2017, you will quickly notice that Exhibition Halls 1 and 2 were demolished. A new state-of-the art hall is meant to take their place. Until then, exhibitors from the field of laboratory medicine will be showcased at their temporary new location in the lightweight hall structures 3a and 18 on the fairgrounds.
22/08/2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
08/08/2017For centuries, scientific research has succeeded by chronicling experiments with pinpoint accuracy. Yet despite all the progress in the actual laboratory, recording is often still done manually, in notebooks, logs or computer systems for instance. In the future, a gesture recognition system could perform this task for scientists.
24/07/2017A new analysis method that uses fetal DNA extracted from the mother’s blood is designed to non-invasively reach a prenatal diagnosis of genetic disorders in a child. A task force of the Hahn Schickard Society for Applied Research is an active part of the "ANGELab" project and co-developed this diagnostic procedure.
02/05/2017India is a land of contradictions. On the one hand, it has densely populated cities with state of the art technology. On the other hand, two-thirds of the population still live under challenging hygienic and financial conditions in the rural areas. Despite these conditions or perhaps because of them, more and more medical technology companies from all over the world are interested in this market.
03/04/2017Instant treatment is absolute vital for patients developing sepsis. Providing a specific therapy early on is key. To manage this the pathogenic organisms need to be identified accurately. But a fungal sepsis can still be a hard nut to crack.
03/04/2017Many aspects are uniformly regulated in Europe, however, hospital hygiene and MRSA prevention, for example, are not. The Netherlands plays a pioneering role in the fight against hospital-acquired infections. The country is an often-cited role model. But can other countries simply adopt the same system? And what makes it so different? MEDICA asked expert Prof. Alexander W. Friedrich.
03/04/2017The laboratory is one of the most important and pivotal bastions in patient care. In the laboratory, acute, chronic and genetic diseases are diagnosed, the progression of diseases such as diabetes is regularly checked or specialists look for biomarkers to adapt cancer therapies.