New Test Predicts the Age -- MEDICA Trade Fair

Image: illustration of a cancer cell; Copyright: panthermedia.net/Sebastian Kaulitzki

Stanford-led study uncovers mutation that supercharges tumor-suppressor

12/10/2017

Cancer researchers have long hailed p53, a tumor-suppressor protein, for its ability to keep unruly cells from forming tumors. But for such a highly studied protein, p53 has hidden its tactics well.
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Image: abstract graphic about hereditary colon cancer; Copyright: IDIBELL

A new genetic marker accounts for up to 1.4 percent of cases of hereditary colon cancer

12/10/2017

The finding, once validated by other research groups, could allow patients with mutations in this gene to follow a clinical approach much more consistent with their genetics.
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Image: image of how Taxanes induce tripolar instead of normal bipolar cell division; Copyright: Munich University Hospital

Cancer drug stimulates tripolar mode of mitosis

21/09/2017

Taxanes inhibit cell division and make cancer cells sensitive to radiation therapy. A current study has investigated the underlying mechanisms of this action – and which biomarkers may be useful for predicting the success of therapy.
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Image: Comparison of normal vs hepatoblastoma liver tissue; Copyright: Etienne Meylan/EPFL

Metabolism can be used to subtype hepatoblastoma tumors

19/09/2017

Looking at cell metabolism instead of histology, EPFL scientists have identified new biomarkers that could help more accurately classify the two main subtypes of hepatoblastoma, a children liver cancer. Hepatoblastoma is a rare pediatric liver cancer, usually diagnosed in the first three years of life.
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Image: Breast cancer stem cell line 1 (BCSC1) from the newly established cell model; Copyright: Maurer Lab

Researchers found a possible new treatment for aggressive triple receptor-negative breast cancer

18/09/2017

Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients.
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Image: heaps of vegetables, one hand holding a blood glucose meter; Copyright: panthermedia.net/dml5050

Biomarkers in the blood prove strong role of food for type 2 diabetes

18/09/2017

A pioneering method, developed at Chalmers University of Technology, has demonstrated its potential in a large study, showing that metabolic fingerprints from blood samples could render important new knowledge on the connection between food and health. The study finds that diet is one of the strongest predictors of type 2 diabetes risk in older women.
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Image: Collage made of two images, one show a round, transparent plastic disc with micro channels, one shows a plastic chip; Copyright: Hahn-Schickard, Image Bernd Müller

Prenatal diagnosis: genetic analysis using droplet PCR

24/07/2017

A new analysis method that uses fetal DNA extracted from the mother’s blood is designed to non-invasively reach a prenatal diagnosis of genetic disorders in a child. A task force of the Hahn Schickard Society for Applied Research is an active part of the "ANGELab" project and co-developed this diagnostic procedure.
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Image: two young scientists looking at the image of a human lung; Copyright: panthermedia.net/Sergey Nivens

COPD – changes in the lungs, changes in the microbiome

21/07/2017

Chronic obstructive pulmonary disease (COPD) can result in structural changes within the lungs over time. Scientists at the Helmholtz Zentrum München have now been able to show that these changes not only affect the organ itself, but also the bacteria that live in the lung. The results have been published in "PLOS ONE".
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Image: A petri dish with yellow bacterial cultures on a black ground; Copyright: panthermedia.net/kwanchaichaiudom

Laboratory medicine: confronting infections with speed and foresight

03/04/2017

The laboratory is one of the most important and pivotal bastions in patient care. In the laboratory, acute, chronic and genetic diseases are diagnosed, the progression of diseases such as diabetes is regularly checked or specialists look for biomarkers to adapt cancer therapies.
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Photo: Child gets pierced into the finger using a lancing device

Diabetes: comprehensive prevention, early "vaccination"?

08/04/2016

A diagnosis of diabetes often catches new patients off guard - for instance if they end up in the emergency room suffering from metabolic decompensation. Children are often affected by this. Their immune system destroys the insulin-producing cells in the pancreas early on in their lives, thus causing type 1 diabetes.
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Photo: Old woman with a smartphone

Health Apps: "Mobile Applications for smartphones have strengths and weaknesses"

22/03/2016

Medical apps like diabetes or high blood pressure diaries are becoming increasingly popular with smartphone users. There are many available choices out there but they are not always clear. Added to this is the question of how the data collected by the apps can be sensibly incorporated into treatment.
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Graphic: The pancreas and the surrounding organs

Pancreatic cancer: diagnosis via signature analysis

08/03/2016

Pancreatic cancer is one of the deadliest forms of cancer because it is difficult to diagnose and only presents with symptoms in the later stages. In the future, a laboratory test developed at the Greifswald University Medicine could make an early detection of this type of cancer and consequently a faster and better treatment possible.
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Photo: Small POC test kit for blood samples; Copyright: bate-web/Spelleken

Nutrition: finding intolerances in the blood

27/11/2015

More and more people suffer from allergies and food intolerances. Laboratory diagnosis for these often takes long and can be inaccurate. Healthcare practitioners increasingly rely on point-of-care tests to avoid costly laboratory tests and quickly find solutions for their patients.
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Theranostics: Complex particles for tomorrow's medicine

01/10/2015

It is a portmanteau, a mixture of two words. This way it saves us time and trouble while speaking because the human speech apparatus is lazy. And it describes a mixture of procedures: the combination of two procedures that would normally be separate in medicine. We are talking about theranostics.
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Small companions: How wearables change our lives

01/09/2015

They can be seen everywhere: at the wrists, in the ear, clipped to the belt. Wearables are small technical assistants who are built to collect and partially also to analyze data. Some of them collect measurable health data, others "only" count their user’s steps or measure the surrounding UV radiation. The fact is, however, that wearables are en vogue and are used for many different cases.
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Prostate cancer: Agent with theranostic potential

03/08/2015

Endoradiotherapy can be very unpleasant for cancer patients, since it does not only harm tumor cells, but also healthy ones. Sometimes, patients even need to stop therapy because of the side effects. Physicians and researchers are thus continuously searching for ways to transport radiopharmaceuticals directly and exclusively to their target.
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Tumor markers: State-of-the-art diagnostics for personalized medicine

01/06/2015

When cancer is diagnosed, the terms tumor markers or biomarkers keep popping up. They describe characteristics that are not found in healthy persons. The classic tumor markers can be easily detected in blood samples or other body fluids. Other analysis methods require more effort. Yet they all share one thing in common: biomarkers indicate a potential tumor.
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Lung cancer: A blood test evaluates the effectiveness of therapy

01/06/2015

Can liquid biopsies become the new trend in cancer diagnostics? The medical world has asked this question for quite some time. The first globally approved liquid biopsy-based test for lung cancer shows that this can work. Yet further findings and research are still required to establish this less invasive method in diagnostics.
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Cancer Immunotherapy: Individual mutations as new target structures

01/06/2015

A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
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Photo: Object slides

Tissue storage: "Our top biobanks are internationally leading the charge"

02/02/2015

Only projects with a solid foundation are successful in the long run. This is also true for science. Biobanks are the most important component of this foundation when it comes to fundamental biomedical research: Only high quality tissue samples that are stored there make conclusive research possible - for example in search of the causes of tumorigenesis.
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