New Class of Drugs for the Reversible Inhibition of Proteasomes -- MEDICA Trade Fair

Image: A volunteer receives an injection in the PREVAIL Ebola vaccine clinical trial; Copyright: PREVAIL

Experimental Ebola vaccines elicit year-long immune response

16/10/2017

Results from a large randomized, placebo-controlled clinical trial in Liberia show that two candidate Ebola vaccines pose no major safety concerns and can elicit immune responses by one month after initial vaccination that last for at least one year.
Read more
Image: tools for blood testing; Copyright: panthermedia.net/gisne

Blood samples may provide patient radiosensitivity answers

13/10/2017

How much radiation or chemotherapy can a certain person handle? With help from blood or tissue testing, it may be possible to answer this question in advance, which in turn could improve treatment, as research at Sahlgrenska Academy shows.
Read more
Image: cross-section illustration of blood vessel; Copyright: panthermedia.net/alexmit

Likely new treatment target identified for diabetic retinopathy

11/10/2017

In oxygen-compromising conditions like diabetes, the body grows new blood vessels to help, but the result is often leaky, dysfunctional vessels that make bad matters worse.
Read more
Image: proteins that stand guard at transmembrane channels in the walls of nerve cells; Copyright: Rice University/UTHEALTH

Nerve cells' gatekeepers take many forms

11/10/2017

Rice, UTHealth researchers use light-sensitive molecules to track proteins critical to cell signaling.
Read more
Image: Immune cells are more activated (red) in the brains of mice with the gene TREM2 (left) than in those without the gene (right); Copyright: DAVID HOLTZMAN LAB

Alzheimer's gene poses both risk and benefits

10/10/2017

Study suggests role of inflammation in brain disease is complicated.
Read more
Image: woman holding a pink ribbon to her chest; Copyright: panthermedia.net/tomas_anderson

Genetic targets to chemo-resistant breast cancer identified

10/10/2017

Research led by Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast cancer.
Read more
Image: microscope image of fluorescent cancer cells; Copyright: panthermedia.net/vshivkova

New approaches in targeted cancer therapy

06/10/2017

In a large-scale testing procedure, scientists from Cologne University Hospital have explored the effects of more than 1,500 substances on different kinds of cancer cells. The results from this study are a fundamental prerequisite for the development of new therapies for NMC, an aggressive cancer which is often lethal.
Read more
Image: stacked pills; Copyright: panthermedia.net/Dieter Beselt

Even open-label placebos work – if they are explained

06/10/2017

For some medical complaints, open-label placebos work just as well as deceptive ones. As psychologists from the University of Basel and Harvard Medical School report in the journal 'Pain', the accompanying rationale plays an important role when administering a placebo.
Read more
Image: transparent human head, showing the brain and firing synapses; Copyright: panthermedia.net/the_lightwriter

Researchers of TU Dresden have pioneered a brain-network bio-inspired algorithm to predict new therapeutic targets of approved drugs

29/09/2017

An international team of scientists led by Dr. Carlo Vittorio Cannistraci, Junior Group Leader of the Biomedical Cybernetics lab at the BIOTEChnology Center TU Dresden, has developed a powerful computational method that can exploit the principles of brain-network self-organization.
Read more
Image: shaking hands of an elderly woman holding a glass of water; Copyright: panthermedia.net/Astrid08

Diabetes medicine reduces Parkinson's risk

28/09/2017

A Norwegian study shows that the taking of diabetes medicine reduces the risk of getting Parkinson's disease.
Read more
Image: cross section through a healthy bone above cross section of a bone with osteoporosis ; Copyright: panthermedia.net/Roberto_Biasini

Researchers describe mechanism that underlies age-associated bone loss

25/09/2017

This knowledge can provide targets in the search for novel bone-loss therapeutics to treat osteoporosis.
Read more
Image: model of a human brain with luminous areas; Copyright: panthermedia.net/pixologic

Drugs in disguise heal the brain

22/09/2017

The treatment of brain diseases is on the verge of a breakthrough. Researchers from Aalborg University are developing a new method that 'smuggles' medicine past the brain's defense systems, giving hope that diseases such as Alzheimer's can one day be cured.
Read more
Image: image of how Taxanes induce tripolar instead of normal bipolar cell division; Copyright: Munich University Hospital

Cancer drug stimulates tripolar mode of mitosis

21/09/2017

Taxanes inhibit cell division and make cancer cells sensitive to radiation therapy. A current study has investigated the underlying mechanisms of this action – and which biomarkers may be useful for predicting the success of therapy.
Read more
Image: yellow warning sign with the word

Asthma drug from the garden center

15/09/2017

The coralberry could offer new hope for asthmatics: researchers at the University of Bonn have extracted a new kind of active pharmaceutical ingredient from its leaves to combat this widespread respiratory disease.
Read more
Image: a human skeleton, several joints highlighted red; Copyright: panthermedia.net/eraxion

New osteoporosis treatment uses traditional Chinese herb to prevent bone loss

12/09/2017

An herb widely used in traditional Chinese medicine might hold the key to a new osteoporosis therapy that could prevent bone loss without causing side effects.
Read more
Image: venes and arteries; Copyright: panthermedia.net/Spectral

How new blood vessels sprout

11/09/2017

IBS biologists discovered a key regulator of normal as well as pathological formation of new blood vessels.
Read more
Image: three pill boxes with different coloured pills; Copyright: panthermedia.net/garyphoto

Mayo Clinic researchers review the clinical potential of senolytic drugs on aging

05/09/2017

Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals.
Read more
Image: many different pills lying on the table; Copyright: Swiss Institute of Bioinformatics

From cancer evolution to personalized therapies

24/08/2017

Being able to predict the resistance or sensitivity of a tumour cell to a drug is a key success-factor of cancer precision therapy. But such a prediction is made difficult by the fact that genetic alterations in tumours change dynamically over time and are often interdependent, following a pattern that is poorly understood.
Read more
Image: a box with different pills; Copyright: panthermedia.net/duskbabe

Newly discovered pathway for pain processing could lead to new treatments

24/08/2017

The discovery of a new biological pathway involved in pain processing offers hope of using existing cancer drugs to replace the use of opioids in chronic pain treatment, according to scientists at McGill University.
Read more
Image: Empa’s multicellular model, which is mimicking the placental barrier: a core of connective tissue cells, surrounded by trophoblast cells; Copyright: Empa

Medication for the unborn baby

21/08/2017

An Empa team has succeeded in developing a new three-dimensional cell model of the human placental barrier. The "model organ" can quickly and reliably deliver new information on the intake of substances, such as nano-particles, by the placental barrier and on any possible toxic effects for the unborn child.
Read more
Image: microscopic view of salmonella; Copyright: HZI/Manfred Rohde

Researchers discover Achilles' heel of bacteria

10/08/2017

Salmonellae are particularly resistant to antibiotics since they possess not only one, but two membranes that protect them from harmful substances. This makes them members of the so-called Gram-negative bacteria. Since Salmonella infections are becoming increasingly difficult to treat with antibiotics, researchers are looking for alternative agents to control these pathogens.
Read more
Image: x-ray of the kidneys; Copyright: panthermedia.net/Sebastian Kaulitzki

Drug therapy from lethal bacteria could reduce kidney transplant rejection

09/08/2017

An experimental treatment derived from a potentially deadly microorganism may provide lifesaving help for kidney transplant patients, according to an international study led by investigators at Cedars-Sinai.
Read more
Image: two glasses with medication in front of simple symbols for men and women; Copyright:

Do we need separate his and hers medicine cabinets?

03/08/2017

Perhaps you have come across the titles "Men are from Mars, women are from Venus" or "Why men don’t listen and women can’t read maps": just two of the many books and articles – some enlightening or amusing and others irritating – that theorise about fundamental differences between men and women.
Read more
Image: blood is taken from a finger and analysed by a blood testing device; Copyright:hes_so_valais_wallis

Without any delay: drug dose adjustment at the point of care

01/08/2017

Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
Read more
Image: Print-out of an ECG curve, a stethoscope and some pills; Copyright: panthermedia.net/ocskaymark

Anticoagulant drugs are being prescribed against safety advice

28/07/2017

A study by researchers at the University of Birmingham has shown that GPs are prescribing anticoagulants to patients with an irregular heartbeat against official safety advice.
Read more
Image: A white silk worm is climbing over leaves; Copyright: Oxford Silk Group

Silk 'micrococoons' could be used in biotechnology and medicine

28/07/2017

Microscopic versions of the cocoons spun by silkworms have been manufactured by a team of researchers. The tiny capsules, which are invisible to the naked eye, can protect sensitive molecular materials, and could prove a significant technology in areas including food science, biotechnology and medicine.
Read more
Image: A reseacher from South Afrika in his laboratory; Copyright: Stefan Els

Alternative antimicrobial compounds could come from wastewater

26/07/2017

Municipal wastewater may become a key ally in the fight against antibiotic-resistant disease-causing bacteria and fungi, a new study at Stellenbosch University (SU) found.
Read more
Image: Schematic of a point of care testing scenario; Copyright: IMTEK - Laboratory for Sensors

Personalize your medication dosages

24/07/2017

Initial clinical tests show that biosensors could pave the way for a personalized antibiotherapy in the future.
Read more
Image: A smiling old man is sitting next to a group of younger people; Copyright: panthermedia.net/SimpleFoto

Diseases of aging: lifestyle and prevention also pay off

01/12/2016

A German proverb says, "Old age is like a hospital that accepts all diseases," and medicine confirms that older people are not only considerably more susceptible to infectious diseases than they were in middle age, but that body and mind are also less resilient and recover slower or not at all from adverse effects or injuries.
Read more
Photo: Pregnancy test

Disaster medicine or disastrous medicine?

04/01/2016

Most Europeans think it was a long time ago, but the residents of West Africa clearly feel the consequences of the Ebola epidemic that broke out in December 2013 and still continues today. So far, approximately 11,300 people have died as a result of the outbreak; more than 28,000 contracted the disease.
Read more
Graphic: stent in a blood vessel

Mechanical thrombectomy: stroke treatment 2.0

01/12/2015

Each year, approximately 250,000 Germans suffer a stroke. This makes stroke the third leading cause of death after heart disease and cancer. The circulatory disorder that occurs in the brain is normally treated using systemic thrombolysis, a procedure that bears various risks. Unlike mechanical thrombectomy, which offers clear advantages by comparison.
Read more

Prostate cancer: Agent with theranostic potential

03/08/2015

Endoradiotherapy can be very unpleasant for cancer patients, since it does not only harm tumor cells, but also healthy ones. Sometimes, patients even need to stop therapy because of the side effects. Physicians and researchers are thus continuously searching for ways to transport radiopharmaceuticals directly and exclusively to their target.
Read more

Radiopharmaceuticals: Individualized diagnostics and therapy

03/08/2015

Malignant tumors can be fought with X-rays – usually with radiation therapy from outside the body. Nuclear medicine physicians can also accomplish this inside the body with radioactive materials, called radiopharmaceuticals. They also offer big benefits for clinical diagnostics as long as a specific target can be assigned to them.
Read more

Wanted: rapid test to prevent deep vein thrombosis

01/07/2015

Deep vein thrombosis is not just a risk factor for frequent flyers but also for wearers of cardiovascular implants and newly operated patients. Blood thinners prevent these dangerous blood clots from forming, but they need to be carefully adjusted and do not work the same way in every patient. A detailed analysis of platelets (thrombocytes) could prevent complications in the future.
Read more

Cancer Immunotherapy: Individual mutations as new target structures

01/06/2015

A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with MEDICA.de, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
Read more

Euthanasia – A Human Right?

01/12/2014

Several weeks ago on November 1, 2014, 29-year-old Brittany Maynard, who suffered from terminal brain cancer, took drugs to end her life surrounded by her family. This was preceded by months of despair and anguish, but also by love and a lust for life as the young woman describes in several videos she recorded to fight for the right to die with dignity.
Read more
Photo: People in the waiting room of a doctor's office

Vaccines: activatable depot to replace multiple injections

22/08/2014

Besides antibiotics, vaccines may be the most important development in medicine: they protect us from diseases by “introducing” our immune system to pathogens. This way, a small injection saves us from severe and potentially mortal courses of disease.
Read more

"We don’t know why certain pharmaceuticals bind especially well while others bind barely at all"

10/02/2014

Prof. Joachim Heberle from the Free University of Berlin wants to make the smallest protein structures visible under the microscope. He wants to accomplish this with an infrared microscope, originating in the field of physics. He told MEDICA.de which technology is behind all this and what he also wants to examine with it in the future.
Read more
Photo: Man and woman visit a physician

"Gender-specific adjustments in clinical diagnostics and therapy can be expected"

15/01/2014

In Western civilization, equality of women and men has been a topic for many years and is already being successfully implemented in many areas, even if many obstacles still need to be overcome – the introduction of quotas for women in boardrooms, just to mention one of them.
Read more

"The Virus Manipulates the Host Cell on Different Levels"

08/01/2014

Heart diseases can be triggered by special viruses that affect the cardiac muscle. Preventive drugs could definitely be developed – if the virus does not mutate.
Read more