History and Future of Cryosurgery -- MEDICA - World Forum for Medicine


Cryoalfa Europe Ltd

History and Future of Cryosurgery

The fundamental basis of modern refrigeration technology we owe to brilliant German Carl von Linde. His pioneering work is due to gas liquefaction. The medicine is an exposed application- and market area for refrigeration engineering. By means of ( liquefied ) cryogenic gases the methods for the cryotreatments were able to develop further.

Cryotherapy and cooling agents were known in ancient times. It’s spoken from “cryosurgery” at destroying tissue ,when the temperatures are far below freezing point.

Parallel to first precisely-targeted use a N2-cooled probe by the the American surgeon Cooper 1961, in Europe, the Dresden’s team of doctors at the University Clinic were the most active in the basic research in the field of cryomedicine. Their most important cognition is: The optimal cryosurgery requires a temperature minimum about -40 °C in the tissue in order treat successfully unwanted (benign and malignant) cells. With a high rate of freezing speed of more than 100 K / min it comes to intra-and extracellular ice crystal formation that causes irreversible damage to the cells. A slight rate of thawing speed leads to massive intracellular water intake that results in a rupture of the cell membrane and acts additively to the destruction of the cells (German Working Group cryosurgery).

Today there are essentially three standard freezing agents to the spectrum of the coolants in Dermatologic Surgery: N2-nitrogen (up to -196 °C), CO2 snow (up to -79 °C) and N2O- nitrous oxide (up to - 89 °C) as "Liquid freezing" and in closed probes (contact freezing) for superficial skin lesions and above all, because of the lower cryogenic adhesive effect of oral and genital transition skin compared with N2 (Akt.Dermatol .2009; 35:279-282).
The sufficient effectiveness of liquid N2O (-89 °C) is often underestimated and isn’t taken advantage ; Clinical studies show that "the range, not the effect on the effective range for liquid N2O is lower (" German dermatologist " 1 / 2003) . Other propagated refrigerants, such as gas mixtures in the cans are inadequate for many indications and confuse the users.

Modern cryosurgery is now working with fixed operating parameters (such as constant operating temperature of -89 °C with a freezing rate of more than 100 K / min, metered-controlled sterile refrigerant’s quantity and other features), with what conditions are created to obtain reproducible results of treatment. The Cryoalfa devices with the "Liquid freezing" system fulfill these requirements, and give the oriented user satisfied patients. The Cryoalfa- technology (the inventor of "liquid freezing" – system (patented)) is simply, the devices are miniaturized , there are various powerfully applicators and therefore useful&applicable in the diverse practices in health care. They fit even in any lab coat. Many common lesions can be quite SIMPLY treated with them. A patient-oriented therapy for well-being of patients without side effects and high cost-benefit effect of a medical or aesthetical-dermatologically treatment.

The further development this simple technology opens enormous innovation potential corresponding to the rapidly advancing modernest manufacturing technologies in micro -and nano scale. The most promising application is the operation in inner regions of the body (prostate - and liver treatments).

Modern cryosurgery is no longer just an alternative to conventional surgery. The development of minimalinvasive cryosurgery demonstrates one of the most challenging tasks to the developer today's medical technologies .