And unlike girls without a family history, this already-elevated risk rises with increasing alcohol consumption. "The most common question we hear from women with a family history of breast disease is how can we prevent breast cancer in our daughters," says Doctor Graham A. Colditz. "This points to a strategy to lower risk — or avoid increasing risk — by limiting alcohol intake."
This study is one of the first to look at alcohol consumption in adolescents and the risk of breast disease. Most studies linking alcohol to the risk of developing breast cancer focus on women in their 40s, 50s and 60s and on their risk of invasive breast cancer, not the risk of early, benign lesions that may lead to invasive breast cancer.
One such study found a moderate increase in breast cancer risk with as few as three to six drinks per week for any adult women, regardless of family history.
"In the current study, we have tried to disentangle the effects of alcohol in women with a family history that includes both breast cancer and benign breast disease, compared to women with no family history," Colditz says. "And we are seeing the strongest effect of alcohol in women with breast disease in the family."
The new study of younger women began in 1996 with more than 9,000 girls from all 50 states who are daughters of participants in the Nurses' Health Study II. The girls were ages nine to 15 when they completed baseline questionnaires. Follow-up questionnaires over the next five years and surveys in 2003, 2005 and 2007 tracked family history, alcoholic beverage intake, height, weight, waist circumference and age of first menstrual period, among other factors that influence breast cancer risk.
The researchers first looked at the effects of family history, independent of alcohol. They found that when a young woman's mother or aunt had breast cancer, she was more than twice as likely to be diagnosed with benign breast disease than a young woman with no family history. Similarly, daughters of mothers with benign breast disease were almost twice as likely to develop benign breast disease themselves.
And alcohol heightened a young girl's risk further if she had a family history. Girls whose mothers, aunts or grandmothers had breast cancer were more likely to develop benign breast disease, and their risk increased with the amount of alcohol they consumed. The same was true of the daughters of women with benign breast disease.
MEDICA.de; Source: Washington University School of Medicine