Smoking during pregnancy has many adverse effects on fetal development.
Andrea Jurisicova and colleagues at the University of Toronto, Canada, found that female mice injected under the skin with polycyclic aromatic hydrocarbons (PAHs) — environmental toxins found in cigarette smoke — pre-pregancy or while lactating were found to have normal sized litters. However, their female offspring had markedly reduced numbers of resting and early growing follicles —cell clusters that each contain a single egg.
Further analysis indicated that the effects of PAHs on the number of follicles in female offspring were mediated through the aryl hydrocarbon receptor (Ahr), which upregulated expression of the gene Harakiri that makes a protein that causes cells to die by a process known as apoptosis. The potential importance of these findings for women of child-bearing age was demonstrated by the observation that PAHs triggered similar molecular pathways in human ovarian tissue transplanted into immunocompromised mice.
MEDICA.de; Source: Journal of Clinical Investigation