The Prize, which was established in 1992, recognises a researcher whose ground-breaking work has contributed greatly to the field of haematology. For more than a quarter-century, Stanley has pioneered studies of the biology and action of the growth factor called Colony Stimulating Factor-1 (CSF-1). He isolated and identified CSF-1 as the primary regulator of tissue macrophage and osteoclast production. He defined its receptor, physiology and roles in development and cancer. He identified and elucidated the function of several intracellular signaling molecules that act downstream of the CSF-1 receptor. He and his colleagues established several mouse models to investigate the roles of CSF-1 and the CSF-1 receptor in development and diseases that include leukemia, solid tumors, osteoporosis, nephritis and atherosclerosis.
His studies also have furthered general understanding of the role of growth factors in regulation of cell proliferation, differentiation and function. The Thomas Prize is one of numerous honours that Dr. Stanley has received throughout his career. Other notable honours include two Method to Extend Research in Time (MERIT) Awards from the National Institutes of Health, awarded in 1989 and 2002, respectively; a Leukemia Society of America Scholar Award (1977); an Irma T. Hirschl Career Scientist Award (1983); the Marie T. Bonazinga Research Award of the Society for Leukocyte Biology (1989); and being named to the “Roll of Honor” by the International Union Against Cancer.
A native of Australia, Stanley received his bachelor’s degree from the University of Western Australia and his Ph.D. degree in medical biology from the University of Melbourne.
MEDICA.de; Source: Yeshiva University