Drug-coated stents prove better than surgery to keep clogged arteries open; © panthermedia.net/Mile Atanasov
Minimally invasive procedure proves better than surgery when angioplasty fails in patients with severely blocked leg arteries. Drug-eluting stents can keep clogged leg arteries open, preventing amputation of the leg.
"Peripheral arterial disease (or PAD) is becoming increasingly prevalent due to our aging population and the obesity and diabetes epidemics," said medical doctor Robert A. Lookstein, lead researcher and chief of interventional radiology at Mount Sinai Medical Center in New York. "Many PAD patients are not candidates for surgery and are seeking minimally invasive options. This therapy is an emerging technology that is safe and effective for treating critical limb ischemia. This treatment helps alleviate pain and avoid amputation," he noted.
An estimated 20 percent of North Americans age 65 or older suffer from peripheral arterial disease, said Lookstein. Individuals with PAD do not get enough blood circulation in the narrowed arteries in their legs and other extremities. The most severe form of the disease is a condition called critical limb ischemia, when arteries become dangerously narrow or completely obstructed. Those with critical limb ischemia can start to feel pain in their legs at rest and develop sores on their feet and lower legs that do not heal. If the condition goes untreated, amputation of the foot or leg may be necessary. Drug-eluting stents can open up those clogged arteries and prevent amputation, according to Lookstein.
In the study, 107 patients with critical limb ischemia had 171 drug-eluting stents placed in blocked leg arteries. Six months after treatment 90 percent of the stents remained opened. Subsequent check-ups at one and two years showed just a slight decline, with 84 percent and 70 percent, respectively, of treated arteries remaining open. All patients in the study treated in the early stages of critical limb ischemia were able to avoid amputation.
With minimally balloon angioplasty, interventional radiologists use medical imaging to advance a tiny tube called a catheter through blood vessels to the site of the blockage. A tiny balloon is expanded, opening up the blocked artery; however, the vessel often becomes reclogged over time, a process called restenosis. To keep the arteries from reclogging, doctors can deposit a tiny expandable tube (stent) to keep the artery propped open. In this study, the stents were drug-eluting, meaning they were impregnated with an immunosuppressant drug similar to those taken by organ transplant recipients to prevent the rejection of a new organ. The drug-eluting stent is grafted along the wall of the narrowed artery forcing it open. The drug continues to be emitted over time, preventing the artery from reclogging.
"The study shows that this technology is superior to balloon angioplasty and rivals the results of surgical bypass," said Lookstein. "It is safe, it is durable and the outcomes are spectacular. The vast majority of patients were able to avoid amputation and dramatically improve their quality of life," he added.
MEDICA.de; Source: Society of Interventional Radiology