In a research report, the scientists describe how this device can measure and collect a type of cells needed to build vascular tissue, called endothelial progenitor cells, using only 200 microliters of blood. The development is also significant because it allows scientists to collect these cells much more easily than current techniques allow, bringing laboratory-created tissue for vascular bypass surgeries another step closer to reality.
"This simple device is a promising tool for the pediatric and adult population in detecting, diagnosing, monitoring, and providing the option of treating cardiovascular disease by utilizing a small quantity of blood," said lead researcher Shashi K. Murthy of the Department of Chemical Engineering at Northeastern University in Boston.
To collect the cells, the device works similar to a magnet. Specifically, the inside is coated with antibodies that only bind to endothelial progenitor cells. Blood flows through the device through a funnel-like opening (except the blood enters through the narrow end and exits through the wide end), passes over the antibodies, and endothelial progenitor cells are "picked up" in the process. In addition to allowing researchers to collect cells from a very small amount of blood, the device's design also provides researchers with a new model to study the effects that blood flow in the body has on cell binding like clots form in arteries.
MEDICA.de; Source: Federation of American Societies for Experimental Biology