Cells in stiffer tissues are squeezed into mutating more often -- MEDICA Trade Fair

Cells in stiffer tissues are squeezed into mutating more often

When it comes to cancerous mutations, cells in soft tissues like bone marrow and the brain tend to exhibit fewer irregularities than their stiffer somatic brethren in the lungs or bone. According to researchers at the University of Pennsylvania, this isn't only due to differences between the cells' type and function, but also to the rigid forces of resistance that act when they move and divide.

02/29/2016

Graphic: Cancer cell in bloodstream

When the cells migrate and force their way through the pores over a 24-hour period, they deform and accumulate DNA damage; © panthermedia.net/vitanovski