Differences in collagen build-up (blue) in two tissue samples: The left image shows a thick collagen wall around a foreign material; to the right, collagen is more evenly dispersed; © UW/Lei Zhang
Expensive, state-of-the-art medical devices and surgeries often are thwarted by the body’s natural response to attack something in the tissue that appears foreign. University of Washington (UW) engineers have demonstrated a way to prevent this.
The UW researchers created a synthetic substance that fully resists the body’s natural attack response to foreign objects. Medical devices such as artificial heart valves, prostheses and breast implants could be coated with this polymer to prevent the body from rejecting an implanted object. “It has applications for so many different medical implants, because we literally put hundreds of devices into the body,” said Buddy Ratner, a UW professor of bioengineering and of chemical engineering. “We could not achieve this level of excellence in healing before we had this synthetic hydrogel.”
The body’s biological response to implanted devices – medical technologies that often cost millions to develop – has frustrated experts for years. After an implant, the body usually creates a protein wall around the medical device, cutting it off from the rest of the body. Scientists call this barrier a collagen capsule. Collagen is a protein that is naturally found in our bodies, particularly in connective tissues such as tendons and ligaments. If a device such as an artificial valve or an electrode sensor is blocked off from the rest of the body, it usually fails to work. Physicians and scientists have tried to minimize this, but they have not been able to eliminate it, Ratner said.
Ratner’s collaborator and co-author Shaoyi Jiang, a UW professor of chemical engineering, and his team implanted the polymer substance into the bodies of mice. The substance is known as a hydrogel, a flexible biomedical material swollen with water. It is made from a polymer that has both a positive and negative charge, which serves to deflect all proteins from sticking to its surface. Scientists have found that proteins appearing on the surface of a medical implant are the first signs that a larger collagen wall will form.
After three months, Jiang and his team found that collagen was loosely and evenly distributed in the tissue around the polymer, suggesting that the mice bodies did not even detect the polymer’s presence.
For humans, the first three weeks after an implant are the most critical, because by then the body will show signs of isolating the implant by building a collagen wall. If this has not happened in the first several weeks, it is likely the body will not default to an attack response toward the object. “Scientists have tried many materials, and with no exception, this is the first non-porous, synthetic substance demonstrating that no collagen capsule forms, which could have positive implications for implantable materials, tissue scaffolds and medical devices,” Jiang said.
The UW researchers plan to test this in humans, likely by working with manufacturers to coat an implantable device with the polymer, then measure its ability to ward off protein build-up.
MEDICA.de; Source: University of Washington