BioNike Proxera Intensive Face Serum -- MEDICA - World Forum for Medicine


BioNike ICIM International SRL

BioNike Proxera Intensive Face Serum

Dry skin is due to changes to the skin barrier and loss of the physiological, albeit small, water content of the stratum corneum of skin.

The concentration of water in the dermis and in vital epidermis layers tends to remain constant at around 60/70%, contrary to what happens in the stratum corneum, which is physiologically low in water content, and risks to lose even this small water amount should the natural water-retaining systems of skin not work properly. In order to minimize water loss, the stratum corneum, in addition to the barrier function, features an additional system called a "water holding capacity", which works based on the hygroscopic characteristics of larger and smaller tissue components in which electrically charged sites are generated, thereby enabling such sites to hold many particles of water. Amongst the various components having a great hygroscopic power we have the so-called natural moisturizing factor (NMF), consisting of a blend of low molecular weight, highly hydrophilic substances, predominantly found in between corneocytes, capable of holding water in amounts equal to four times their own weight. Being water-soluble, however, the NMF is subject to being washed out when skin is washed. Amongst the other factors that contribute to hydration there is hyaluronic acid, a complex carbohydrate belonging to the family of mucopolysaccharides, which however, differently from other mucopolysaccharides, can reach very high molecular weights. Hyaluronic acid has long been considered a unique and exclusive constituent of the connective tissue matrix (dermis), but in recent years it has been found that keratinocytes produce hyaluronic acid as well and pour it into the tiny slits between them, where it reaches much higher concentrations compared to that in the dermis, although its half-life does not exceed 24 hours.
Hyaluronic acid is a polymer that shows the characteristics of a gel, whose viscosity changes depending on the length and molecular weight of the polymer itself.

In topical preparations, the level of penetration and absorption of hyaluronic acid in the different skin tissues varies according exactly to its molecular weight.

PROXERA INTENSIVE SERUM exploits the properties of this active ingredient, combining it in different forms (free and carried) and molecular weights (high, medium, low and very low). The result is a highly moisturizing (prevents water loss), regenerating (normalizes the cell renewal process), protective (prevents damage caused by external agents, such as UV rays), firming (improves elasticity and skin tone) product.

o High molecular weight hyaluronic acid (1.800 KDa): stays on the skin surface to increase hydration and work as an important water reserve;
o Medium molecular weight hyaluronic acid (700 – 800 KDa): provides deeper and long-lasting hydration;
o Low molecular weight hyaluronic acid (50 KDa): penetrates deeper skin layers, improving skin elasticity,
o Very low molecular weight hyaluronic acid (< 10 KDa): characterized by a high bio-availability, very quickly penetrates deeper skin layers, keeping them hydrated
o Hyaluronic acid in microspheres: it is slowly released and, by capturing and retaining the outflowing transepidermal water, it increases skin hydration