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Image: Human breast cancer tissue stained by immunofluorescence; Copyright: Jackson Laboratory

New way to target advanced breast cancers

21/09/2018

A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
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Image: Observing never-before-seen behaviors of live cancer cells under the microscope; Copyright: panthermedia.net / AlexLipa

New micro-platform reveals cancer cells’ natural behavior

20/09/2018

A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics.
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Image: A new brain imaging method for a correct diagnostic of Alzheimer`s disease; Copyright: panthermdia.net / londondeposit

New method enables accurate diagnosis of Alzheimer's disease

20/09/2018

Diagnosing Alzheimer's disease can be difficult, as several other conditions can cause similar symptoms. Now a new brain imaging method can show the spread of specific tau protein depositions, which are unique to cases with Alzheimer's.
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Image: An AI tool can analyse images of patients' lung tumors; Copyright: NYU School of Medicine

Artificial intelligence can determine lung cancer type

19/09/2018

Led by researchers at NYU School of Medicine and published online in Nature Medicine, the study found that a type of artificial intelligence (AI), or "machine learning" program, could distinguish with 97 percent accuracy between adenocarcinoma and squamous cell carcinoma-two lung cancer types that experienced pathologists at times struggle to parse without confirmatory tests.
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Image: The microscope image shows mitochondria, the cell's power plants; Copyright: AG Herrmann

Proteins surf to mitochondria – Novel transport pathway discovered

18/09/2018

Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell. Proteins destined to mitochondria, are not directly transported to mitochondria but are directed to the surface of the endoplasmic reticulum.
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Image: Dr. Dao Nguyen looking at Pseudomonas aeruginosa; Copyright: McGill University Health Centre

New means to fight "un-killable" bacteria in healthcare settings

18/09/2018

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have identified new means of fighting drug-tolerant bacteria, a growing global threat as menacing as drug-resistant microbes. Little is known about the mechanisms leading to tolerance, a strategy that makes bacteria "indifferent" to antibiotics and almost "un-killable," which results in chronic infections.
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Image: molecules occupying a tiny space between heart muscle cells; Copyright:  Virginia Tech/Gourdie lab

The heart: Digital or analog?

29/08/2018

Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have found evidence that may disrupt conventional understanding about how electrical activity travels in the heart -- a discovery that potentially can lead to new insight into medical problems such as heart arrhythmia and sudden cardiac death.
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Image: biosensor in a petri dish; Copyright: Michael Daniele

Biosensor allows real-time monitoring for organs-on-a-chip

22/08/2018

A new biosensor allows researchers to track oxygen levels in real time in "organ-on-a-chip" systems, making it possible to ensure that such systems more closely mimic the function of real organs. This is essential if organs-on-a-chip hope to achieve their potential in applications such as drug and toxicity testing.
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Image:cancer cells; Copyright: panthermedia.com/Vitanovski

AI model 'learns' from patient data

14/08/2018

MIT researchers are employing novel machine-learning techniques to improve the quality of life for patients by reducing toxic chemotherapy and radiotherapy dosing for glioblastoma, the most aggressive form of brain cancer.
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Image:W. Christopher Risher, Ph.D., assistant professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine; Copyright: Marshall University Joan C. Edwards School of M

3D electron microscopy reveals Insights into brain circuitry

13/08/2018

New research from a team led by Marshall University scientist W. Christopher Risher, Ph.D., reveals novel molecular insights into how multiple cell types drive the formation and maturation of brain circuits.
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Image: female laboratory assistant at the microscope, man shows her something on a tablet; Copyright: panthermedia.net/matej kastelic

Using big data to predict immunotherapy responses

10/08/2018

In the age of Big Data, cancer researchers are discovering new ways to monitor the effectiveness of immunotherapy treatments.
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Image: close-up of the worn wristband; Copyright: Abbas Furniturewalla

Smart wristband to monitor health

09/08/2018

Rutgers University-New Brunswick engineers have created a smart wristband with a wireless connection to smartphones that will enable a new wave of personal health and environmental monitoring devices.
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Image: images from the the new method; Copyright: UZH

New method refines cell sample analysis

08/08/2018

Researchers at the University of Zurich have developed a novel method for analyzing cells and their components called Iterative Indirect Immunofluorescence Imaging (4i). This innovation greatly refines the standard immunofluorescence imaging technique used in biomedicine and provides clinicians with an enormous amount of data from each individual sample.
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Image: Triculture System Fully Replicates Alzheimer's Pathology; Copyright: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease

Microfluidic system incorporates neuroinflammation

03/08/2018

Building on their development of the first culture system to replicate fully the pathology behind Alzheimer's disease, a Massachusetts General Hospital (MGH) research team has now produced a system that includes neuroinflammation, the key biological response that leads to the death of brain cells.
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Image: Setting up a microscope; Copyright:Allen Institute

Openscope: the first shared observatory for neuroscience

02/08/2018

The Allen Institute for Brain Science, a division of the Allen Institute, announced the launch of OpenScope, a project that will give researchers access to the Institute's "observatory of the mind" to study the activity of nerve cells in the visual cortex of the mouse. OpenScope was modeled after shared astronomy observatories that have been the seat of major findings about the physical universe.
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Image: An image of oligortical spheroids in wells; Copyright: Case Western Reserve School of Medicine

A new milestone in laboratory grown human brain tissue

01/08/2018

A cutting-edge laboratory technique turns human stem cells into brain-like tissue now recapitulates human brain development. The new study from Case Western Reserve University School of Medicine was published in Nature Methods and shows how to grow brain "organoids"--self-organizing mini spheres that now contain all the major cell types found in the human cerebral cortex-in laboratory dishes.
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Image: 3D single molecule super-resolution images of the amyloid plaques; Copyright: Purdue University image/Fenil Patel

3D super-resolution imaging to see Alzheimer's

30/07/2018

Recent studies show that 40 percent of Americans over the age of 85 have Alzheimer's disease, and that the disease begins 10 to 20 years before people show up at the doctor's office with memory problems.
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Image: diagram for high-throughput flow cytometry in drug discovery; Copyright: Alexandre Chigaev, University of New Mexico

High-throughput flow cytometry in drug discovery

27/07/2018

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.
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Image: 3D single molecule super-resolution images of the amyloid plaques associated with Alzheimer's disease; Copyright: Purdue University image/Fenil Patel

Alzheimer's disease: new development in 3D super-resolution imaging

25/07/2018

Recent studies show that 40 percent of Americans over the age of 85 have Alzheimer's disease, and that the disease begins 10 to 20 years before people show up at the doctor's office with memory problems.
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Image: three-dimensional model of a left heart ventricle; Copyright: Luke MacQueen and Michael Rosnach/Harvard University

A 3-D model of a human heart ventricle

24/07/2018

Harvard University researchers have bioengineered a three-dimensional model of a human left heart ventricle that could be used to study diseases, test drugs and develop patient-specific treatments for heart conditions such as arrhythmia.
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Image: graphic of the process with bones and stem cells; Copyright: Christina Ng, New York Stem Cell Foundation

Novel bioengineering technique for personalized bone grafts

23/07/2018

Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE).
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Image: person in protective clothing holding the sensor in his hand; Copyright: RMIT University

New detection sensor for type 1 diabetes

19/07/2018

Researchers are developing early detection technology for Type 1 diabetes that can accurately predict if a child is at risk of the chronic disease.
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Image: Small brown mole on the back of a hand; Copyright: panthermedia.net/Mario Hahn

Early detection: Tattoo signals cancer – and more

09/07/2018

People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
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Photo: X-ray and MRI scan of a knee; Copyright: panthermedia.net/Bunyos30

Cell technology used to treat osteochondral knee defect

29/06/2018

A joint paper by Kazan Federal University and Tatarstan Republican Clinical Hospital appeared in Frontiers in Medicine. As the publication describes, autologous cells of stromal vascular fraction were transplanted to a 36-year-old man with the use of fibrin matrix. The patient, whose injury had been caused by a fall, then has been under supervision for 2 years.
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Image: Two examples of tissue shapes; Copyright: Stefano De Renzis, EMBL

Constructing new tissue shapes with light

28/06/2018

Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer. Researchers at EMBL have succeeded in guiding the folding and thus shape of tissues with optogenetics: a technique to control protein activity with light.
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Image: AcCellerator research device at an exhibition stand; Copyright: Daniel Klaue, ZELLMECHANIK DRESDEN GmbH

Cells in the speed trap – diagnosis in a matter of seconds

22/06/2018

A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
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Image: Two hands are holding a tubular frame that is carrying a glistening wet, white tube; Copyright: Leibniz University of Hanover/Institute of Technical Chemistry

Tissue engineering: how to grow a bypass

23/04/2018

A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01/03/2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research

22/02/2018

Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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Image:

"Spray-On" muscle fibers for biomimetic surfaces

08/01/2018

Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
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Image: interferometric detection of scattered light, iSCAT; Copyright: MPL

Interface between Physics and Medicine: new interdisciplinary center

22/08/2017

Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
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Image: blood is taken from a finger and analysed by a blood testing device; Copyright:hes_so_valais_wallis

Without any delay: drug dose adjustment at the point of care

01/08/2017

Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
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Image: An eye surgeon and an assistant are treating a patient with a surgical laser; Copyright: University Hospital Dresden/Felix Koopmann

Eye surgery: precision and prevention with femtosecond lasers

03/07/2017

Precision work is absolutely essential in eye surgery since the surgical site is very minute and sensitive. This is why eye surgeons have been using lasers for years. Femtosecond lasers are especially well suited to serve this purpose because they are able to cut tissue with great precision and little energy, which prevents unwanted side effects of surgery.
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Image: Zebrafish brain, fluorescence image (left) and 3D image (right); Copyright: private

"A 3D movie of the brain in action"

08/12/2016

Watching millions of neurons in the brain interacting with each other – for a long time this was possible only to a limited extent. The current techniques can visualize only superficial layers or the imaging they use is too slow. But now, Prof Daniel Razansky and his team have found a new method to visualize the brain activity – by using optoacoustics.
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Image: User interface of a software; Copyright: Helmholtz Zentrum München

Cell under observation: "The software lets us study the development on video"

08/08/2016

What happens when stem cells differentiate? What molecular characteristics do they have? Questions that can now be easier answered with the help of a new open-source software. We spoke with Prof. Fabian Theis at the Helmholtz Center Munich, who participated in the software development.
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Image: Closed eyes of a patient. Electrodes are attached above the eyebrows; Copyright: savir-center.com

Electrical Stimulation: Using Electrical Pulses to Combat Blindness

22/07/2016

Millions of people all over the world suffer from partial blindness – caused by glaucoma, a stroke or traumatic brain injury. For years, the loss of vision was deemed irreversible. But now a new treatment makes it possible to improve eyesight and vision.
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Photo: two physicians working at a test set-up

Atherosclerosis: Getting to the root of the problem with a turbo gene

09/02/2016

Many people suffer from atherosclerosis, especially in developed countries. The buildup of fatty deposits inside the arterial blood vessels leads to strokes and heart attacks. Now, a new method is designed to get to the root of the problem, and with the help of nanoparticles inject new turbo replacement cells into the blood vessels which are intended to exert their curative effect.
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Photo: child with broken arm

Different specialties, one goal – treating children right

01/02/2016

Children, especially newborns, are generally no longer simply considered to be small adults whose treatment just needs to be "reduced". This is why a pediatrician’s education includes several specialties because ultimately everything in terms of care comes together here.
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Photo: pipette in petri dish

Great leaps forward thanks to new methods

01/02/2016

Self-healing powers like a superhero on the big screen? That’s the aim of regenerative medicine; at least in a very broad sense. This promising field of biomedicine is currently highly dynamic with innovative technologies and development. New methods are designed to help propel medicine into a whole new sphere.
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From the periodic table of elements into medicine: silicon for theranostics

01/10/2015

Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
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Hospital crisis communication: A crisis knows no rules

02/03/2015

Crises come in many shapes and sizes. Whether it’s poor hygiene, thefts or treatment errors – once the crisis has arrived, things need to move quickly. For hospitals in particular, the right crisis communication is key. Yet many medical facilities still neglect the fact that crisis communication starts before the actual crisis takes place.
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Photo: Tissue sections on object slides

Digital pathology: From microscope slide to virtual microscopy

02/02/2015

The digitization of medicine moves on. Researchers, physicians and patients equally benefit from this development – thanks to improved diagnostics with highly sensitive devices, today findings can be comprehensively analyzed and treatment decisions made on a broadened basis. Digitization also offers the area of pathology interesting fields of application.
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Photo: interaction between the proteins

IBD: When genetics and environment interact

05/01/2015

T-cells are the guardians of our immune system. When they show changes, it can lead to severe inflammatory responses in the body. It is believed that the T-cells in persons who are affected by inflammatory bowel disease don’t work properly. Two proteins that can be found on activated T-cells and that interact with each other are now being analyzed.
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Xenon magnetic resonance imaging: making pathological changes in the body visible

03/11/2014

As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
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Wound treatment with fish skin

03/11/2014

The treatment of chronic wounds is extremely problematic. Chronic wounds can take months or years to heal and some even never heal resulting in over 100.000 amputations taking place annually in the US alone. A new technology from Iceland, that is based on fish skin and is already used clinically, allows for improved healing of chronic and burn wounds.
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Photo: Dr. Anna-Maria Liphardt

Laboratory in Space: Hot on the Trails of Cartilage Degradation

01/10/2014

On November 10, 2014, astronaut Alexander Gerst will return to Earth from the International Space Station (ISS). He is not just anxiously expected by his family, but also by Dr. Anna-Maria Liphardt from the Institute of Biomechanics and Orthopedics at the German Sport University Cologne
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Cultured skin makes large-scale transplantations possible

01/07/2014

Large burns require skin grafting. Surgeons remove split-thickness skin grafts and apply them to the injured areas. Now skin that has been made in a laboratory is meant to help in covering burns as well as chronic wounds and thus promote the healing process. Researchers in Zurich have been working on this for more than 13 years.
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Diagnosing Parkinson's: the skin is revealing

01/07/2014

In patients with Parkinson's, neural cells in the brain die off that produce the neurotransmitter dopamine. Certain physical symptoms that can indicate the disease follow years later. But a reliable diagnosis can only be made through examination of the brain after the patient's death, and not during his lifetime.
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Fat is the best medicine: "Adipose tissue contains many multipotent stem cells, approximately 500 times more than bone marrow"

01/07/2014

The not so popular “love handles“ could revolutionize medicine in the near future. In cooperation with the University of Rostock (Professor Hermann Seitz), the human med AG Company currently seeks to develop a device that is able to gently remove adipose tissue during surgery and subsequently isolate stem cells.
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Surgery: "Our camera detects the tiniest remainder of a tumor"

03/02/2014

Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
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